Journal of Dermatological Science
Volume 30, Issue 2 , Pages 100-107 , November 2002

Interleukin-13 gene polymorphism G4257A is associated with atopic dermatitis in Japanese patients

  • Yuichiro Tsunemi

      Affiliations

    • Department of Dermatology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81-3-5800-8661; fax: +81-3-3814-1503
    • ,
  • Hidehisa Saeki

      Affiliations

    • Department of Dermatology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
    • ,
  • Koichiro Nakamura

      Affiliations

    • Department of Dermatology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960-1295, Japan
    • ,
  • Takashi Sekiya

      Affiliations

    • Department of Allergy and Rheumatology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
    • ,
  • Koichi Hirai

      Affiliations

    • Department of Allergy and Rheumatology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
    • ,
  • Takashi Kakinuma

      Affiliations

    • Department of Dermatology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
    • ,
  • Hideki Fujita

      Affiliations

    • Department of Dermatology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
    • ,
  • Noriko Asano

      Affiliations

    • Department of Dermatology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
    • ,
  • Yuka Tanida

      Affiliations

    • Department of Dermatology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
    • ,
  • Motoshi Wakugawa

      Affiliations

    • Department of Dermatology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
    • ,
  • Hideshi Torii

      Affiliations

    • Department of Dermatology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
    • ,
  • Kunihiko Tamaki

      Affiliations

    • Department of Dermatology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

Received 28 March 2002 ,Revised 6 June 2002 ,Accepted 12 June 2002.

References 

  1. Punnonen J, Aversa G, Cooks BG, McKenzie AN, Menon S, Zurawski G, et al. Interleukin 13 induces interleukin4-independent IgG4 and IgE synthesis and CD23 expression by human B cells. Proc. Natl. Acad. Sci. USA. 1993;90:3730–3734
  2. Hamid Q, Naseer T, Minshall EM, Song YL, Boguniewicz M, Leung DYM. In vivo expression of IL-12 and IL-13 in atopic dermatitis. J. Allergy Clin. Immunol. 1996;98:225–231
  3. Van der Ploeg I, Jeddi Tehrani M, Matuseviciene G, Wahlgren CF, Fransson J, Scheyniue A. IL-13 overexpression in skin is not confirmed to IgE-mediated skin inflammation. Clin. Exp. Immunol. 1997;109:526–532
  4. Katagiri K, Itami S, Hatano Y, Takayasu S. Increased levels of IL-13 mRNA, but not IL-4, are found in vivo in peripheral blood mononuclear cells (PBMC) of patients with atopic dermatitis (AD). Clin. Exp. Immunol. 1997;108:289–294
  5. Takamatsu Y, Hasegawa M, Sato S, Takehara K. IL-13 production by peripheral blood mononuclear cells from patients with atopic dermatitis. Dermatology. 1998;196:377–381
  6. Wakugawa M, Hayashi K, Nakamura K, Tanaki K. Eavaluation of mite allergen-induced Th1 and Th2 cytokine secretion of peripheral blood mononuclear cells from atopic dermatitis patients: association between IL-13 and mite-specific IgE levels. J. Dermatol. Sci. 2001;25:116–126
  7. Koning H, Neijens HJ, Baert MRM, Oranje AP, Savelkoul HFJ. T cell subsets and cytokines in allergic and non-allergic children. Analysis of IL-4, IFN-γ and IL-13 mRNA expression and protein production. Cytokine. 1997;9:416–426
  8. Akdis M, Akdis CA, Weigl L, Disch R, Blaser K. Skin-homing, CLA+ memory T cells are activated in atopic dermatitis and regulate IgE by an IL-13-dominated cytokine pattern. IgG4 counter-regulation by CLA-memory T cells. J. Immunol. 1997;159:4611–4619
  9. Wills-Karp M, Luyimbazi J, Xu X, Schofield B, Neben TY, Karp CL, et al. Interleukin-13: central mediator of allergic asthma. Science. 1998;282:2258–2261
  10. Grunig G, Warnock M, Wakil AE, Venkayya R, Brombacher F, Rennick DM, et al. Requirement for IL-13 independently of IL-4 in experimental asthma. Science. 1998;282:2261–2263
  11. Zhu Z, Homer RJ, Wang Z, Chen Q, Geba GP, Wang J, et al. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J. Clin. Invest. 1999;103:779–788
  12. Cookson WOCM, Ubhi B, Lawrence R, Abecasis GR, Walley AJ, Cox HE, et al. Genetic linkage of childhood atopic dermatitis to psoriasis susceptibility loci. Nat. Genet. 2001;27:372–373
  13. Forrest S, Dunn K, Elliott K, Fitzpatrick E, Fullerton J, McCarthy M, et al. Identifying genes predisposing to atopic eczema. J. Allergy Clin. Immunol. 1999;104:1066–1070
  14. Beyer K, Nickel R, Freidhoff L, Björkstén B, Huang SK, Barnes KC, et al. Association and linkage of atopic dermatitis with chromosome 13q12–14 and 5q31–33 markers. J. Invest. Dermatol. 2000;115:906–908
  15. Söderhäll C, Bradley M, Kockum I, Wahlgren CF, Luthman H, Nordenskjöld M. Linkage and association to candidate regions in Swedish atopic dermatitis families. Hum. Genet. 2001;109:129–135
  16. The Collaborative Study on the Genetics of Asthma (CSGA) . A genome-wide search for asthma susceptibility loci in ethnically diverse populations. Nat. Genet. 1997;15:389–392
  17. Marsh DG, Neely JD, Breazeale DR, Ghosh B, Freidhoff LR, Ehrlich-Kautzky E, et al. Lineage analysis of IL-4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations. Science. 1994;264:1152–1156
  18. Noguchi E, Shibasaki M, Arinami T, Takeda K, Maki T, Miyamoto T, et al. Evidence for linkage between asthma atopy in childhood and chromosome 5q31–33 in a Japanese population. Am. J. Respir. Crit. Care Med. 1997;156:1390–1393
  19. Postma DS, Bleecker ER, Amelung PJ, Holroyd LJ, Xu J, Panhuysen CI, et al. Genetic susceptibility to asthma-bronchial hyperresponsiveness coinherited with a major gene for atopy. New Engl. J. Med. 1995;333:894–900
  20. Palmer LJ, Daniels SE, Rye PJ, Gibson NA, Tay GK, Cookson WO, et al. Linkage of chromosome 5q and 11q gene markers to asthma-associated quantitative traits in Australian children. Am. J. Respir. Crit. Care Med. 1998;158:1825–1830
  21. Ober C, Cox NJ, Abney M, Di Rienzo A, Lander ES, Changyaleket B, et al. Genome-wide search for asthma susceptibility loci in a founder population. The collaborative study on the genetics of asthma. Hum. Mol. Genet. 1998;7:1393–1398
  22. Graves PE, Kabesch M, Halonen M, Holberg CJ, Baldini M, Fritzsch C, et al. A cluster of seven tightly linked polymorphisms in the IL-13 gene is associated with total serum IgE levels in three populations of white children. J. Allergy Clin. Immunol. 2000;105:506–513
  23. Laundy GJ, Spink CF, Keen LJ, Wood NAD, Bidwell JL. A novel polymorphism in the human interleukin-13 promoter. Eur. J. Immunogenet. 2000;27:53–54
  24. Van der Pouw Kraan TCTM, van Veen A, Boeije LCM, van Tuyl SAP, de Groot ER, Stapel SO, et al. An IL-13 promoter polymorphism associated with increased risk of allergic asthma. Genes Immunol. 1999;1:61–65
  25. Heinzmann A, Mao XQ, Akaiwa M, Kreomer RT, Gao PS, Ohshima K, et al. Genetic variants of IL-13 signalling and human asthma and atopy. Hum. Mol. Genet. 2000;9:549–559
  26. Liu X, Nickel R, Beyer K, Wahn U, Ehrlich E, Freidhoff LR, et al. MAS-study group. An IL-13 coding region variant is associated with a high total serum IgE level and atopic dermatitis in the German multicenter atopy study (MAS-90). J. Allergy Clin. Immunol. 2000;106:167–170
  27. Pantelidis P, Jones MG, Welsh KI, Taylor AN, Du Bois RM. Identification of four novel interleukin-13 gene polymorphisms. Gene Immunol. 2000;1:341–345
  28. Hanifin JM, Rajka G. Diagnostic features of atopic dermatitis. Acta Derm. Venereol. 1980;92:44S–47S
  29. National Asthma Education and Prevention Program. Expert Panel Report 2: Guidelines for the Diagnosis and Management of Asthma. Bethesda, MD: National Institutes of Health, April 1997. Publication No. 97–4051.
  30. European Task Force on Atopic Dermatitis . Severity scoring of atopic dermatitis: the SCORAD index. Consensus report of the European Task Force on Atopic Dermatitis. Dermatology. 1993;186:23–31
  31. Kunz B, Oranje AP, Labreze L, Stalder JF, Ring J, Taieb A. Clinical validation and guidelines for the SCORAD index: consensus report of the European Task Force on Atopic Dermatitis. Dermatology. 1997;195:10–19
  32. Terwillinger JD, Ott J. In: Handbook of human linkage analysis. Baltimore: Johns Hopkins University Press; 1999;p. 188–193
  33. Lewontin RC. The interaction of selection and linkage. General considerations, heterotic models. Genetics. 1964;49:49–67
  34. MacLean JA, Sauty A, Luster AD, Drazen JM, De Sanctis GT. Antigen-induced airway hyperresponsiveness, pulmonary eosinophilia, and chemokine expression in B cell-deficient mice. Am. J. Respir. Cell Mol. Biol. 1999;20:379–387
  35. van de Rijn M, Mehlhop PD, Judkins A, Rothenberg ME, Luster AD, Oettgen HC. A murine model of allergic rhinitis: studies on the role of IgE in pathogenesis and analysis of the eosinophil influx elicited by allergen and eotaxin. J. Allergy Clin. Immunol. 1998;102:65–74
  36. Zurawski G, de Vries JE. Interleukin-13, an interleukin-4-like cytokine that acts on monocytes and B cells, but not on T cells. Immunol. Today. 1994;15:19–26
  37. Bochner BS, Klunk DA, Sterbinsky SA, Coffman RL, Schleimer PR. IL-13 selectively induce vascular cell adhesion molecule-1 expression in human endothelial cells. J. Immunol. 1995;154:799–803
  38. Ying S, Meng Q, Barata LT, Robinson DS, Durham SR, Kay AB. Association between IL-13 and IL-4 (mRNA and protein), vascular cell adhesion molecule-1 expression, and the infiltration of eosinophils, macrophages, and T cells in allergen-induced late-phase cutaneous reactions in atopic subjects. J. Immunol. 1997;158:5050–5057

PII: S0923-1811(02)00065-8

Journal of Dermatological Science
Volume 30, Issue 2 , Pages 100-107 , November 2002

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