Journal of Dermatological Science
Volume 30, Issue 2 , Pages 108-115 , November 2002

Elevated expression of hepatocyte and keratinocyte growth factor in cultured buccal-mucosa-derived fibroblasts compared with normal-skin-derived fibroblasts

Received 11 April 2002 ,Revised 17 June 2002 ,Accepted 19 June 2002.

References 

  1. Deitch EA, Wheelahan TM, Rose MP, Clothier J, Cotter J. Hypertrophic burn scars: analysis of variables. J. Trauma. 1983;23:895–898
  2. Hata K, Kagami H, Ueda M, Torii S, Matsuyama M. The characteristics of cultured mucosal cell sheet as a material for grafting: comparison with cultured epidermal cell shirt. Ann. Plast. Surg. 1995;34:530–538
  3. Tredget EE, Nedelec B, Scott PG, Ghahary A. Hypertrophic scars, keloids, and contractures. The cellular and molecular basis for therapy. Surg. Clin. North Am. 1997;77:701–730
  4. Ansel J, Perry P, Brown J, Damm D, Phan T, Hart C, et al. Cytokine modulation of keratinocytes cytokines. J. Invest. Dermatol. 1990;94:101–107s
  5. Nozaki S, Feliciani C, Sauder DN. Keratinocyte cytokines. Adv. Dermatol. 1992;7:83–100
  6. Li J, Farthing PM, Ireland GW, Thornhill MH. IL-1 alpha and IL-6 production by oral and skin keratinocytes: similarities and differences in response to cytokine treatment in vitro. J. Oral Pathol. Med. 1996;25:157–162
  7. Formanek M, Knerer B, Temmel A, Thurnher D, Millesi W, Kornfehl J. Oral keratinocytes derived from the peritonsillar mucosa express the proinflammatory cytokine IL-6 without prior stimulation. J. Oral Pathol. Med. 1998;27:202–206
  8. Stephens P, Davies KJ, al-Khateeb T, Shepherd JP, Thomas DW. A comparison of ability of intra-oral and extra-oral fibroblasts to stimulate extracellular matrix reorganization in a model of wound contraction. J. Dent. Res. 1996;75:1358–1364
  9. Lee HG, Eun HC. Differences between fibroblasts cultured from oral mucosa and normal skin: implication to wound healing. J. Dermatol. Sci. 1999;21:176–182
  10. Kerner B, Formanek M, Temmel A, Mrtinek H, Schickinger B, Kornfehl J. The role of fibroblasts from oropharyngeal mucosa in producing proinflammatory and mitogenic cytokines without prior stimulation. Eur. Arch. Otorhinolaryngol. 1999;256:266–270
  11. Schneider EL, Mitsui Y, Au KS, Shorr SS. Tissue-specific differences in cultured human diploid fibroblasts. Exp. Cell Res. 1977;108:1–6
  12. Tsuboi R, Sato C, Shi CM, Ogawa H. Stimulation of keratinocyte migration by growth factors. J. Dermatol. 1992;19:652–653
  13. Matsumoto K, Hashimoto K, Yoshikawa K, Nakumura T. Marked stimulation of growth and motility of human keratinocytes by hepatocyte growth factor. Exp. Cell Res. 1991;196:114–120
  14. Marchese C, Rubin J, Ron D, Faggioni A, Torrisi MR, Messina A, et al. Human keratinocyte growth factor activity on proliferation and differentiation of human keratinocytes: differentiation response distinguishes KGF from EGF family. J. Cell Physiol. 1990;144:326–332
  15. Tsuboi R, Sato C, Kurita Y, Ron D, Rubin JS, Ogawa H. Keratinocte growth factor (FGF-7) stimulates migration and plasminogen activator activity of normal human keratinocytes. J. Invest. Dermatol. 1993;101:49–53
  16. Bhora FY, Dunkin BJ, Batzri S, Aly HM, Bass BL, Sidawy AN, et al. Effect of growth factors on cell proliferation and epithelization in human skin. J. Surg. Res. 1995;59:236–244
  17. Grabbe J, Welker P, Dippel E, Czarnetzki BM. Stem cell factor, a novel cutaneous growth factor for mast cells and melanocytes. Arch. Dermatol. Res. 1994;161:78–84
  18. van Wyk CW, Oliver A, Hoal-van Helden EG, Grobler Rabie AF. Growth of oral and skin fibroblasts from patients with oral submucous fibrosis. J. Oral Pathol. Med. 1995;24:349–353
  19. Sato C, Tsuboi R, Shi CM, Rubin JS, Ogawa H. Comparative study of hepatocyte growth factor/scatter factor and keratinocyte growth factor effects on human keratinocytes. J. Invest. Dermatol. 1995;104:958–963
  20. Gille J, Khalik M, König V, Kaufmann R. Hepatocyte growth factor/scatter factor (HGF/SF) induces vascular permeability factor (VPF/VEGF) expression by cultured keratinocytes. J. Invest. Dermatol. 1998;111:1160–1165
  21. Matsuda Y, Matsumoto K, Ichida T, Nakamura T. Hepatocyte growth factor suppresses the onset of liver cirrhosis and abrogate lethal hepatic dysfunction in rats. J. Biochem. Tokyo. 1995;118:643–649
  22. Yaekashiwa M, Nakayama S, Ohmuma K, Sakai T, Abe T, Satoh K, et al. Simultaneous and delayed administration of hepatocyte growth factor equally represses the fibrotic change in murine lung injury induced by bleomycin: a morphologic study. Am. J. Respir. Crit. Care Med. 1997;156:1937–1944
  23. Mizuno S, Matsumoto K, Nakamura T. Hepatocyte growth factor suppresses interstitial fibrosis in a mouse model of obstructive nephropathy. Kidney Int. 2001;54:1304–1314
  24. Taniyama Y, Morishita R, Nakagami H, Moriguchi A, Sakonjo H, Kim S, et al. Potential contribution of a novel antifibrotic factor, hepatocyte growth factor, to prevention of myocardial fibrosis by angiotensin II blockade in cardiomyopathic hamster. Circulation. 2000;102:246–252
  25. Verrecchia F, Mauviel A. Transforming growth factor-beta signaling through the Smad pathway: role in extracellular matrix gene expression and regulation. J. Invest. Dermatol. 2002;118:211–215
  26. Yuan W, Varga J. Transforming growth factor-beta repression of matrix metalloproteinase-1 in dermal fibroblasts involves Smad3. J. Biol. Chem. 2001;276:38502–38510
  27. Cao B, Guo Z, Zhu Y, Xu W. The potential role of PDGF, IGF-1, TGF-beta expression in idiopathic pulmonary fibrosis. Chin. Med. J. 2000;113:776–782
  28. Klahr S. Progression of chronic renal disease. Heart Dis. 2001;3:205–209
  29. Zhang K, Garner W, Cohen L, Rodriguez J, Phan S. Increased types I and III collagen and transforming growth factor-beta 1 mRNA and protein in hypertrophic burn scar. J. Invest. Dermatol. 1995;104:750–754
  30. Matsumoto K, Okazaki H, Nakamura T. Up-regulation of hepatocyte growth factor gene expression by interleukin-1 in human skin fibroblasts. Biochem. Biophys. Res. Commun. 1992;188:235–243
  31. Maas-Szabowski N, Fusenig N. Interleukin-1-induced growth factor expression in postmitotic and resting fibroblasts. J. Invest. Dermatol. 1996;107:849–855
  32. Chedid M, Rubin JS, Csaky KG, Aaronson SA. Regulation of keratinocyte growth factor gene expression by interleukin 1. J. Biol. Chem. 1994;269:10753–10754
  33. Brauchel M, Angermeyer K, Hubner G, Werner S. Large induction of keratinocyte growth factor expression by serum growth factors and pro-inflammatory cytokines in cultured fibroblasts. Oncogene. 1994;11:3199–3204

PII: S0923-1811(02)00066-X

Journal of Dermatological Science
Volume 30, Issue 2 , Pages 108-115 , November 2002

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