Journal of Dermatological Science
Volume 30, Issue 2 , Pages 154-160 , November 2002

TGF-β1-mediated regulation of thymus and activation-regulated chemokine (TARC/CCL17) synthesis and secretion by HaCaT cells co-stimulated with TNF-α and IFN-γ

  • Xueyi Zheng

      Affiliations

    • Department of Dermatology, Fukushima Medical University School of Medicine, Hikarigaoka 1, Fukushima 960-1295, Japan
    • ,
  • Koichiro Nakamura

      Affiliations

    • Department of Dermatology, Fukushima Medical University School of Medicine, Hikarigaoka 1, Fukushima 960-1295, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81-24-548-2111x2403; fax: +81-24-548-5412
    • ,
  • Michiko Tojo

      Affiliations

    • Department of Dermatology, Fukushima Medical University School of Medicine, Hikarigaoka 1, Fukushima 960-1295, Japan
    • ,
  • Noritaka Oyama

      Affiliations

    • Department of Dermatology, Fukushima Medical University School of Medicine, Hikarigaoka 1, Fukushima 960-1295, Japan
    • ,
  • Akiko Nishibu

      Affiliations

    • Department of Dermatology, Fukushima Medical University School of Medicine, Hikarigaoka 1, Fukushima 960-1295, Japan
    • ,
  • Masataka Satoh

      Affiliations

    • Department of Dermatology, Fukushima Medical University School of Medicine, Hikarigaoka 1, Fukushima 960-1295, Japan
    • ,
  • Takashi Kakinuma

      Affiliations

    • Department of Dermatology, University of Tokyo, Tokyo, Japan
    • ,
  • Motoshi Wakugawa

      Affiliations

    • Department of Dermatology, University of Tokyo, Tokyo, Japan
    • ,
  • Kunihiko Tamaki

      Affiliations

    • Department of Dermatology, University of Tokyo, Tokyo, Japan
    • ,
  • Fumio Kaneko

      Affiliations

    • Department of Dermatology, Fukushima Medical University School of Medicine, Hikarigaoka 1, Fukushima 960-1295, Japan

Received 20 March 2002 ,Revised 24 June 2002 ,Accepted 26 June 2002.

References 

  1. Kaplan AP. Chemokines, chemokine receptors and allergy. Int. Arch. Allergy Immunol. 2001;124:423–431
  2. Baggiolini M. Chemokines and leukocyte traffic. Nature. 1998;392:565–568
  3. Zlontik A, Yoshie O. The biology of chemokines and their receptors. Immunity. 2000;12:121–127
  4. Vestergaard C, Bang K, Gesser B, Yoneyama H, Matsushima K, Larsen CG. A Th2 chemokine, TARC, produced by keratinocytes may recruit CLA+ CCR4+ lymphocytes into lesional atopic dermatitis skin. J. Invest. Dermatol. 2000;115:640–646
  5. Imai T, Baba M, Nishimura M, Kakizaki M, Takagi S, Yoshie O. The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4. J. Biol. Chem. 1997;272:15036–15042
  6. Sallusto F, Palermo B, Lenig D, Miettinen M, Matikainen S, Julkunen I, et al. Distinct patterns and kinetics of chemokine production regulate dendritic cell function. Eur. J. Immunol. 1999;29:1617–1625
  7. Rottman JB, Smith TL, Ganley KG, Kikuchi T, Krueger JG. Potential role of the chemokine receptors CXCR3, CCR4, and the integrin alphaEbeta7 in the pathogenesis of psoriasis vulgaris. Lab. Invest. 2001;8:335–347
  8. Vestergaard C, Yoneyama H, Murai M, Nakamura K, Tamaki K, Terashima Y. Overproduction of Th2-specific chemokines in NC/Nga mice exhibiting atopic dermatitis-like lesions. J. Clin. Invest. 1999;104:1097–1110
  9. Imai T, Nagira M, Takagi S, Kakizaki M, Nishimura M, Wang J, et al. Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokine thymus and activation regulated chemokine and macrophage-derived chemokine. Int. Immunol. 1999;11:81–88
  10. Kakinuma T, Nakamura K, Wakugawa M, Mitsui H, Tada Y, Saeki H, et al. Thymus and activation-regulated chemokine in atopic dermatitis: serum thymus and activation-regulated chemokine level is closely related with disease activity. J. Allergy Clin. Immunol. 2001;107:535–541
  11. Kawasaki S, Takizawa H, Yoneyama H, Nakayama T, Fujisawa R, Izumizaki M, et al. Intervention of thymus and activation-regulated chemokine attenuates the development of allergic airway inflammation and hyperresponsiveness in mice. J. Immunol. 2001;166:2055–2062
  12. Vestergaard C, Kirstejn N, Gesser B, Mortensen JT, Matsushima K, Larsen CG. IL-10 augments the IFN-gamma and TNF-alpha induced TARC production in HaCaT cells: a possible mechanism in the inflammatory reaction of atopic dermatitis. J. Dermatol. Sci. 2001;26:46–54
  13. Kumagai N, Fukuda K, Nishida T. Synergistic effect of TNF-alpha and IL-4 on the expression of thymus- and activation-regulated chemokine in human corneal fibroblasts. Biochem. Biophys. Res. Commun. 2000;279:1–5
  14. Arkwright PD, Chase JM, Babbage S, Pravica V, David TJ, Hutchinson IV. Atopic dermatitis is associated with a low-producer transforming growth factor beta (1) cytokine genotype. J. Allergy. Clin. Immunol. 2001;108:281–284
  15. Nakamura K, Kitani A, Strober W. Cell contact—dependent immunosuppression by CD4+ CD25+ regulatory T cells is mediated by cell surface-bound transforming growth factor β. J. Exp. Med. 2001;194:629–644
  16. Wakugawa M, Nakamura K, Kakinuma K, Onai N, Matsushima K, Tamaki K. CC chemokine receptor 4 expression on peripheral blood CD4+ T cells reflects disease activity of atopic dermatitis. J. Invest. Dermatol. 2001;117:188–196
  17. Minshall EM, Leung DY, Martin RJ, Song YL, Cameron L, Ernst P, et al. Eosinophil-associated TGF-beta 1 mRNA expression and airway fibrosis in bronchial asthma. Am. J. Respir. Cell Mol. Biol. 1997;17:326–333
  18. Berin MC, Eckmann L, Broide DH, Kagnoff MF. Regulated production of the T helper 2-type T-cell chemoattractant TARC by human bronchial epithelial cells in vitro and in human lung xenografts. Am. J. Respir. Cell Mol. Biol. 2001;24:382–389

PII: S0923-1811(02)00071-3

Journal of Dermatological Science
Volume 30, Issue 2 , Pages 154-160 , November 2002

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