Journal of Dermatological Science
Volume 30, Issue 2 , Pages 87-93 , November 2002

Neuromediators—a crucial component of the skin immune system

Received 26 August 2002 ,Accepted 26 August 2002.

References 

  1. Scholzen T, Armstrong CA, Bunnett NW, Luger TA, Olerud JE, Ansel JC. Neuropeptides in the skin: interactions between the neuroendocrine and the skin immune systems. Exp. Dermatol. 1998;7:81–96
  2. Ansel JC, Kaynard AH, Armstrong CA, Olerud J, Bunnett N, Payan D. Skin–nervous system interactions. J. Invest. Dermatol. 1996;106:198–204
  3. Regoli D, Nguyen K, Calo G. Neurokinin receptors: comparison of data from classical pharmacology, binding, and molecular biology. Ann. NY Acad. Sci. 1997;812:144–146
  4. Misery L. Skin, immunity and the nervous system. Br. J. Dermatol. 1997;137:843–850
  5. Habler HJ, Timmermann L, Stegmann JU, Janig W. Involvement of neurokinins in antidromic vasodilatation in hairy and hairless skin of the rat hindlimb. Neuroscience. 1999;89:1259–1268
  6. Quinlan KL, Song IS, Bunnett NW, Letran E, Steinhoff M, Harten B, et al. Neuropeptide regulation of human dermal microvascular endothelial cell ICAM-1 expression and function. Am. J. Physiol. 1998;275:C1580–C1590
  7. Smith CH, Barker JN, Morris RW, MacDonald DM, Lee TH. Neuropeptides induce rapid expression of endothelial cell adhesion molecules and elicit granulocytic infiltration in human skin. J. Immunol. 1993;151:3274–3282
  8. Niizeki H, Kurimoto I, Streilein JW. A substance P agonist acts as an adjuvant to promote hapten-specific skin immunity. J. Invest. Dermatol. 1999;112:437–442
  9. Yokote R, Yagi H, Furukawa F, Takigawa M. Regulation of peripheral blood mononuclear cell responses to dermatophagoides farinae by substance P in patients with atopic dermatitis. Arch. Dermatol. Res. 1998;290:191–197
  10. Scholzen TE, Steinhoff M, Bonaccorsi P, Klein R, Amadesi S, Geppetti P, et al  Neutral endopeptidase terminates substance P-induced inflammation in allergic contact dermatitis. J. Immunol. 2001;166:1285–1291
  11. McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, et al. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature. 1998;393:333–339
  12. Scholzen TE, Fastrich M, Brzoska T, Kalden DH, Armstrong CA, Ansel JC, et al. Calcitonin gene-related peptide (CGRP) activation of human dermal microvascular endothelial cell (HDMEC) transcription factor NF-κB and CREB. J. Invest. Dermatol. 2000;115:534
  13. Fox FE, Kubin M, Cassin M, Niu Z, Hosoi J, Torii H, et al. Calcitonin gene-related peptide inhibits proliferation and antigen presentation by human peripheral blood mononuclear cells: effects on B7, interleukin 10, and interleukin 12. J. Invest. Dermatol. 1997;108:43–48
  14. Wang F, Millet I, Bottomly K, Vignery A. Calcitonin gene-related peptide inhibits interleukin 2 production by murine T lymphocytes. J. Biol. Chem. 1992;267:21052–21057
  15. Hosoi J, Murphy GF, Egan CL, Lerner EA, Grabbe S, Asahina A, et al. Regulation of Langerhans cell function by nerves containing calcitonin gene-related peptide. Nature. 1993;363:159–163
  16. Asahina A, Moro O, Hosoi J, Lerner EA, Xu S, Takashima A, et al. Specific induction of cAMP in Langerhans cells by calcitonin gene-related peptide: relevance to functional effects. Proc. Natl. Acad. Sci. USA. 1995;92:8323–8327
  17. Torii H, Hosoi J, Beissert S, Xu S, Fox FE, Asahina A, et al. Regulation of cytokine expression in macrophages and the Langerhans cell-like line XS52 by calcitonin gene-related peptide. J. Leuko. Biol. 1997;61:216–223
  18. Asahina A, Hosoi J, Beissert S, Stratigos A, Granstein RD. Inhibition of the induction of delayed-type and contact hypersensitivity by calcitonin gene-related peptide. J. Immunol. 1995;154:3056–3061
  19. Kitazawa T, Streilein JW. Hapten-specific tolerance promoted by calcitonin gene-related peptide. J. Invest. Dermatol. 2000;115:942–948
  20. Garssen J, Buckley TL, Van Loveren H. A role for neuropeptides in UVB-induced systemic immunosuppression. Photochem. Photobiol. 1998;68:205–210
  21. Dery O, Corvera CU, Steinhoff M, Bunnett NW. Proteinase-activated receptors: novel mechanisms of signaling by serine proteases. Am. J. Physiol. 1998;274:C1429–C1452
  22. Macfarlane SR, Seatter MJ, Kanke T, Hunter GD, Plevin R. Proteinase-activated receptors. Pharmacol. Rev. 2001;53:245–282
  23. Sun G, Stacey MA, Schmidt M, Mori L, Mattoli S. Interaction of mite allergens Der p3 and Der p9 with protease-activated receptor-2 expressed by lung epithelial cells. J. Immunol. 2001;167:1014–1021
  24. Steinhoff M, Corvera CU, Thoma MS, Kong W, McAlpine BE, Caughey GH, et al. Proteinase-activated receptor-2 in human skin: tissue distribution and activation of keratinocytes by mast cell tryptase. Exp. Dermatol. 1999;8:282–294
  25. Steinhoff M, Vergnolle N, Young SH, Tognetto M, Amadesi S, Ennes HS, et al  Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism. Nat. Med. 2000;6:151–158
  26. Derian CK, Eckardt AJ, Andrade-Gordon P. Differential regulation of human keratinocyte growth and differentiation by a novel family of protease-activated receptors. Cell Growth Differ. 1997;8:743–749
  27. Shpacovitch VM, Brzoska T, Buddenkotte J, Stroh C, Sommerhoff CP, Ansel JC, et al. Agonists of proteinase-activated receptor 2 induce cytokine release and activation of nuclear transcription factor kappaB in human dermal microvascular endothelial cells. J. Invest. Dermatol. 2002;118:380–385
  28. Vergnolle N, Bunnett NW, Sharkey KA, Brussee V, Compton SJ, Grady EF, et al  Proteinase-activated receptor-2 and hyperalgesia: a novel pain pathway. Nat. Med. 2001;7:821–826
  29. Eipper BA, Mains RE. Structure and biosynthesis of pro-adrenocorticotropin/endorphin and related peptides. Endocr. Rev. 1980;1:1–27
  30. Slominski A, Wortsman J, Luger T, Paus R, Solomon S. Corticotropin releasing hormone and proopiomelanocortin involvement in the cutaneous response to stress. Physiol. Rev. 2000;80:979–1020
  31. Luger TA, Scholzen T, Grabbe S. The role of α-melanocyte stimulating hormone in cutaneous biology. J. Investig. Dermatol. Symp. Proc. 1997;2:87–93
  32. Teofoli P, Motoki K, Lotti TM, Uitto J, Mauviel A. Proopiomelanocortin (POMC) gene expression by normal skin and keloid fibroblasts in culture: modulation by cytokines. Exp. Dermatol. 1997;6:111–115
  33. Cone RD, Lu D, Koppula S, Vage DI, Klungland H, Boston B, Chen W, Orth DN, Pouton C, Kesterson RA. The melanocortin receptors: agonists, antagonists, and the hormonal control of pigmentation. Recent Prog. Horm. Res. 1996;51.
  34. Luger TA, Scholzen T, Brzoska T, Becher E, Slominski A, Paus R. Cutaneous immunomodulation and coordination of skin stress responses by alpha-melanocyte-stimulating hormone. Ann. NY Acad. Sci. 1998;840:381–394
  35. Hadley ME, Haskell-Luevano C. The proopiomelanocortin system. Ann. NY Acad. Sci. 1999;885:1–21
  36. Getting SJ, Allcock GH, Flower R, Perretti M. Natural and synthetic agonists of the melanocortin receptor type 3 possess anti-inflammatory properties. J. Leukoc. Biol. 2001;69:98–104
  37. Luger TA, Kalden D, Scholzen TE, Brzoska T. Alpha-melanocyte-stimulating hormone as a mediator of tolerance induction. Pathobiology. 1999;67:318–321
  38. Lipton JM, Catania A, Ichiyama T. Marshaling the anti-inflammatory influence of the neuroimmunomodulator alpha-MSH. News Physiol. Sci. 2000;15:192–195
  39. Bhardwaj RS, Becher E, Mahnke K, Hartmeyer M, Schwarz T, Scholzen T, et al. Evidence for the differential expression of the functional alpha melanocyte stimulating hormone receptor MC-1 on human monocytes. J. Immunol. 1997;158:3378–3384
  40. Becher E, Mahnke K, Brzoska T, Kalden DH, Grabbe S, Luger TA. Human peripheral blood-derived dendritic cells express functional melanocortin receptor MC-1R. Ann. NY Acad. Sci. 1999;885:188–195
  41. Manna SK, Aggarwal BB. Alpha-melanocyte-stimulating hormone inhibits the nuclear transcription factor NF-kappa B activation induced by various inflammatory agents. J. Immunol. 1998;161:2873–2880
  42. Kalden DH, Scholzen T, Brzoska T, Luger TA. Mechanisms of the antiinflammatory effects of α-MSH: role of transcription factor NF-κB and adhesion molecule expression. Ann. NY Acad. Sci. 1999;885:254–261
  43. Barcellini W, Colombo G, La Maestra L, Clerici G, Garofalo L, Brini AT, et al. Alpha-melanocyte-stimulating hormone peptides inhibit HIV-1 expression in chronically infected promonocytic U1 cells and in acutely infected monocytes. J. Leukoc. Biol. 2000;68:693–699
  44. Grabbe S, Bhardwaj RS, Steinert M, Mahnke K, Simon MM, Schwarz T, et al. Alpha-melanocyte stimulating hormone induces hapten-specific tolerance in mice. J. Immunol. 1996;156:473–478
  45. Brzoska T, Schwarz A, Moeller M, Altmann B, Kalden DH, Scholzen T, Schwarz T, Grabbe S, Luger TA. Treatment of murine BMDC with α-MSH results in the generation of T-suppressor cells. J. Invest. Dermatol. 2001;117.
  46. Sunderkotter C, Kalden DH, Brzoska T, Sorg C, Luger TA. MSH reduces vasculitis in the local Shwartzman reaction. Ann. NY Acad. Sci. 1999;885:414–418
  47. Adachi S, Nakano T, Vliagoftis H, Metcalfe DD. Receptor-mediated modulation of murine mast cell function by alpha-melanocyte stimulating hormone. J. Immunol. 1999;163:3363–3368
  48. Grutzkau A, Henz BM, Kirchhof L, Luger T, Artuc M. Alpha-melanocyte stimulating hormone acts as a selective inducer of secretory functions in human mast cells. Biochem. Biophys. Res. Commun. 2000;278:14–19
  49. Aebischer I, Stampfli MR, Zurcher A, Miescher S, Urwyler A, Frey B, et al. Neuropeptides are potent modulators of human in vitro immunoglobulin synthesis. Eur. J. Immunol. 1994;24:1908–1913
  50. Raap U, Brzoska T, Päth G, Herz U, Luger TA, Renz H, et al. Melanocyte stimulating hormone (α-MSH) is a modulator of immune responses in allergen-induced airway inflammation in vivo. Allergy. 2001;56:21

PII: S0923-1811(02)00103-2

Journal of Dermatological Science
Volume 30, Issue 2 , Pages 87-93 , November 2002

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