Journal of Dermatological Science
Volume 45, Issue 1 , Pages 73-75 , January 2007

A zinc(II)–glycine complex is an effective inducer of metallothionein and removes oxidative stress

  • Hitoshi Masaki

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +81 3 3966 7755; fax: +81 3 3966 7307.
    • ,
  • Yasunobu Ochiai

      Affiliations

    • Tel.: +81 3 3966 7755; fax: +81 3 3966 7307.
    • ,
  • Yuri Okano

      Affiliations

    • Tel.: +81 3 3966 7755; fax: +81 3 3966 7307.

Received 10 April 2006

References 

  1. Miles AT, Hawksworth GM, Beattie JH, Rodilla V. Induction, regulation, degradation, and biological significance of mammalian metallothioneins. Crit Rev Biochem Mol Biol. 2000;35:35–70
  2. Waalkes MP, Klaassen CD. Concentration of metallothionein in major organs of rats after administration of various metals. Fundam Appl Toxicol. 1985;5:473–477
  3. Palmiter RD, Findley SD, Whitmore TE, Durnam DM. MT-III, a brain-specific member of the metallothionein gene family. Proc Natl Acad Sci USA. 1992;89:6333–6337
  4. Durnam DM, Palmiter RD. Analysis of the detoxification of heavy metal ions by mouse metallothionein. Experientia Suppl. 1987;52:457–463
  5. Hanada K. Photoprotective role of metallothionein in UV-injury—metallothionein-null mouse exhibits reduced tolerance against ultraviolet-B. J Dermatol Sci. 2000;23(S(1)):S51–S56
  6. Ota T, Hanada K, Hashimoto I. The effect of cold stress on UVB injury in mouse skin and cultured keratinocytes. Photochem Photobiol. 1996;64:984–987
  7. Hanada K, Sawamura D, Nakano H, Hashimoto I. Possible role of 1,25-dihydroxyvitamin D3-induced metallothionein in photoprotection against UVB injury in mouse skin and cultured rat keratinocytes. J Dermatol Sci. 1995;9:203–208
  8. Lee J, Youn JI. The photoprotective effect of 1,25-dihydroxyvitamin D3 on ultraviolet light B-induced damage in keratinocyte and its mechanism of action. J Dermatol Sci. 1998;18:11–18
  9. Baba T, Nakano H, Tamai K, Sawamura D, Hanada K, Hashimoto I, et al. Inhibitory effect of beta-thujaplicin on ultraviolet B-induced apoptosis in mouse keratinocytes. J Invest Dermatol. 1998;110:24–28
  10. Yoshikawa Y, Ueda E, Suzuki Y, Yanagihara N, Sakurai H, Kojima K. New insulinomimetic zinc(II) complexes of a-amino acids and their derivatives with Zn(N2O2) coordination mode. Chem Pharm Bull. 2001;49:652–654

PII: S0923-1811(06)00247-7

doi: 10.1016/j.jdermsci.2006.08.009

Journal of Dermatological Science
Volume 45, Issue 1 , Pages 73-75 , January 2007

Article Tools

* Image Usage & Resolution