Journal of Dermatological Science
Volume 45, Issue 1 , Pages 69-72 , January 2007

Epiregulin, a member of the EGF family, is over-expressed in psoriatic epidermis

  • Yuji Shirakata

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +81 89 960 5350; fax: +81 89 960 5352.

Received 19 April 2006

References 

  1. Schon MP, Boehncke WH. Psoriasis. N Engl J Med. 2005;352:1899–1912
  2. Hashimoto K. Regulation of keratinocyte function by growth factors. J Dermatol Sci. 2000;24:S46–S50
  3. Cook PW, Pittelkow MR, Keeble WW, Graves-Deal R, Coffey RJ, Shipley GD. Amphiregulin messenger RNA is elevated in psoriatic epidermis and gastrointestinal carcinomas. Cancer Res. 1992;52:3224–3227
  4. Elder JT, Fisher GJ, Lindquist PB, Bennett GL, Pittelkow MR, Coffey RJ, et al. Overexpression of transforming growth factor alpha in psoriatic epidermis. Science. 1989;243:811–814
  5. Stoll SW, Elder JT. Retinoid regulation of heparin-binding EGF-like growth factor gene expression in human keratinocytes and skin. Exp Dermatol. 1998;7:391–397
  6. Shirakata Y, Komurasaki T, Toyoda H, Hanakawa Y, Yamasaki K, Tokumaru S, et al. Epiregulin, a novel member of the epidermal growth factor family, is an autocrine growth factor in normal human keratinocytes. J Biol Chem. 2000;275:5748–5753
  7. Nitta H, Kishimoto J, Grogan TM. Application of automated mRNA in situ hybridization for formalin-fixed, paraffin-embedded mouse skin sections: effects of heat and enzyme pretreatment on mRNA signal detection. Appl Immunohistochem Mol Morphol. 2003;11:183–187
  8. Cook PW, Piepkorn M, Clegg CH, Plowman GD, DeMay JM, Brown JR, et al. Transgenic expression of the human amphiregulin gene induces a psoriasis-like phenotype. J Clin Invest. 1997;100:2286–2294
  9. Zhang X, Yang D, Ma S, Liu H. Up-regulation of activities of mitogen-activated protein kinase in psoriatic lesions. J Dermatol Sci. 2005;37:118–119
  10. Sano S, Chan KS, Carbajal S, Clifford J, Peavey M, Kiguchi K, et al. Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model. Nat Med. 2005;11:43–49

PII: S0923-1811(06)00248-9

doi: 10.1016/j.jdermsci.2006.08.010

Journal of Dermatological Science
Volume 45, Issue 1 , Pages 69-72 , January 2007

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