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The effect of a low glycemic load diet on acne vulgaris and the fatty acid composition of skin surface triglycerides

  • Robyn N. Smith

      Affiliations

    • School of Applied Sciences, RMIT University, GPO Box 2476V, Melbourne, Victoria 3001, Australia
    • Corresponding Author InformationCorresponding author. Tel.: +61 3 9925 2720; fax: +61 3 9925 5241.
    • ,
  • Anna Braue

      Affiliations

    • Department of Dermatology, Royal Melbourne Hospital, Parkville, Australia
    • ,
  • George A. Varigos

      Affiliations

    • Department of Dermatology, Royal Melbourne Hospital, Parkville, Australia
    • Department of Dermatology, Royal Children's Hospital, Parkville, Australia
    • ,
  • Neil J. Mann

      Affiliations

    • School of Applied Sciences, RMIT University, GPO Box 2476V, Melbourne, Victoria 3001, Australia
    • Australian Technology Network, Centre for Metabolic Fitness, Australia

Received 7 May 2007 ,Revised 17 September 2007 ,Accepted 7 November 2007. Published online 12 July 2010 Corrected Proof

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    Recruitment to completion of participants in trial.

    Recruitment to completion of participants in trial.

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    (a–c): Pattern of sebum droplets from subjects exhibiting low (a), moderate (b) and high (c) levels of follicular sebum outflow.

    (a–c): Pattern of sebum droplets from subjects exhibiting low (a), moderate (b) and high (c) levels of follicular sebum outflow.

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    Percentage lipid impregnated area (95% CI) of sebutapes at baseline and follow up according to dietary group.

    Percentage lipid impregnated area (95% CI) of sebutapes at baseline and follow up according to dietary group.

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    Mean response score of skin oiliness (95% CI) according to dietary group at baseline and follow-up. Note: a lower score reflects a decline in reported skin oiliness. *Follow-up score significantly dif

    Mean response score of skin oiliness (95% CI) according to dietary group at baseline and follow-up. Note: a lower score reflects a decline in reported skin oiliness. *Follow-up score significantly different from baseline P<0.05.

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    (a) Change in acne lesion count as a function of the change in the ratio of SFAs/MUFAs in sebaceous triglycerides. (b) Change in acne lesion count as a function of the change in the ratio 16:0/16:1Δ6+

    (a) Change in acne lesion count as a function of the change in the ratio of SFAs/MUFAs in sebaceous triglycerides. (b) Change in acne lesion count as a function of the change in the ratio 16:0/16:1Δ6+Δ9 in sebaceous triglycerides.

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    (a) Change in the quantity of skin surface lipid as a function of the change in the MUFAs in sebaceous triglycerides. (b) Change in the quantity of skin surface lipid as a function of the change in th

    (a) Change in the quantity of skin surface lipid as a function of the change in the MUFAs in sebaceous triglycerides. (b) Change in the quantity of skin surface lipid as a function of the change in the ratio of SFAs/MUFAs.

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    Schematic illustrating the hypothesized metabolic-endocrine pathway linking a low glycemic load diet and the changes in the fatty acid profile of human sebum production. Abbreviations: SHBG, sex hormo

    Schematic illustrating the hypothesized metabolic-endocrine pathway linking a low glycemic load diet and the changes in the fatty acid profile of human sebum production. Abbreviations: SHBG, sex hormone binding globulin; DHEA-S, dehydroepiandrosterone sulphate.

☆ This study was funded by a research grant from Meat and Livestock Australia. The corresponding author receives a postgraduate scholarship from MINTRAC (National Meat Industry Training Council of Australia). The remaining authors have no potential conflict of interest. This study was the responsibility of the investigators. MLA had no role in data collection, data analysis, data interpretation or submission of this paper for publication.

PII: S0923-1811(07)00363-5

doi: 10.1016/j.jdermsci.2007.11.005

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