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UVB wavelength dependency of antimicrobial peptide induction for innate immunity in normal human keratinocytes

  • Kan Torii

      Affiliations

    • Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Mizuho-ku, Mizuho-cho, Nagoya 467-8601, Japan
    • ,
  • Akira Maeda

      Affiliations

    • Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Mizuho-ku, Mizuho-cho, Nagoya 467-8601, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 52 853 8261; fax: +81 52 852 5449.
    • ,
  • Chiyo Saito

      Affiliations

    • Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Mizuho-ku, Mizuho-cho, Nagoya 467-8601, Japan
    • ,
  • Takuya Furuhashi

      Affiliations

    • Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Mizuho-ku, Mizuho-cho, Nagoya 467-8601, Japan
    • ,
  • Yoichi Shintani

      Affiliations

    • Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Mizuho-ku, Mizuho-cho, Nagoya 467-8601, Japan
    • ,
  • Yuji Shirakata

      Affiliations

    • Department of Dermatology, Ehime University School of Medicine, Matsuyama, Japan
    • ,
  • Akimichi Morita

      Affiliations

    • Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Mizuho-ku, Mizuho-cho, Nagoya 467-8601, Japan

Received 28 June 2009 Published online 12 July 2010 Corrected Proof

References 

  1. Beissert S, Hosoi J, Kühn R, Rajewsky K, Müller W, Granstein RD. Impaired immunosuppressive response to ultraviolet radiation in interleukin-10-deficient mice. J Invest Dermatol. 1996;107:553–557
  2. Loser K, Mehling A, Loeser S, Apelt J, Kuhn A, Grabbe S, et al. Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cells. Nat Med. 2006;12:1372–1379
  3. Schwarz A, Maeda A, Kernebeck K, van Steeg H, Beissert S, Schwarz T. Prevention of UV radiation-induced immunosuppression by IL-12 is dependent on DNA repair. J Exp Med. 2005;201:173–179
  4. Maeda A, Beissert S, Schwarz T, Schwarz A. Phenotypic and functional characterization of ultraviolet radiation-induced regulatory T cells. J Immunol. 2008;180:3065–3071
  5. Shintani Y, Yasuda Y, Kobayashi K, Maeda A, Morita A. Narrowband ultraviolet B radiation suppresses contact hypersensitivity. Photodermatol Photoimmunol Photomed. 2008;24:32–37
  6. Gläser R, Navid F, Schuller W, Jantschitsch C, Harder J, Schröder JM, et al. UV-B radiation induces the expression of antimicrobial peptides in human keratinocytes in vitro and in vivo. J Allergy Clin Immunol. 2009;123:1117–1123
  7. Martinsson H, Yhr M, Enerbäck C. Expression patterns of S100A7 (psoriasin) and S100A9 (calgranulin-B) in keratinocyte differentiation. Exp Dermatol. 2005;14:161–168
  8. Zasloff M. Fighting infections with vitamin D. Nat Med. 2006;12:388–390
  9. Lehdman B, Knuschke P, Meurer M. The UVB-induced synthesis of vitamin D3 and 1α, 25-dihydroxyvitamin D3 (calcitriol) in organotypic cultures of keratinocytes: effectiveness of the narrowband Philips YL-01 lamp (311nm). J Steroid Biochem Mol Biol. 2007;103:682–685
  10. Lande R, Gregorio J, Facchinetti V, Chatterjee B, Wang YH, Homey B, et al. Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature. 2007;449:564–569

PII: S0923-1811(09)00235-7

doi: 10.1016/j.jdermsci.2009.07.011

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