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Journal of Dermatological Science
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L-selectin: Role in regulating homeostasis and cutaneous inflammation
References
- . Adhesion molecule cascades direct lymphocyte recirculation and leukocyte migration during inflammation. Immunol Res. 2000;22:299–317
- . Getting to the site of inflammation: the leukocyte adhesion cascade updated. Nat Rev Immunol. 2007;7:678–689
- α4 integrins mediate lymphocyte attachment and rolling under physiologic flow. Cell. 1995;80:413–422
- A functional role for circulating mouse L-selectin in regulating leukocyte/endothelial cell interactions in vivo. J Immunol. 2002;169:2034–2043
- Leukocyte migration is regulated by L-selectin endoproteolytic release. Immunity. 2003;19:713–724
- . Distinct phenotype of E-selectin-deficient mice. E-selectin is required for slow leukocyte rolling in vivo. Circ Res. 1996;79:1196–1204
- . Optimal selectin-mediated rolling of leukocytes during inflammation in vivo requires intercellular adhesion molecule-1 expression. Proc Natl Acad Sci USA. 1998;95:7562–7567
- . Leukocyte rolling velocities and migration are optimized by cooperative L-selectin and intercellular adhesion molecule-1 functions. J Immunol. 2002;169:4542–4550
- . L-selectin-mediated leukocyte adhesion and migration. In: Ley K editors. Adhesion molecules: function and inhibition. Basel: Birkhauser Verlag AG; 2007;p. 27–70
- Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice. Immunity. 1994;1:247–260
- . Efficient lymphocyte migration across high endothelial venules of mouse Peyer's patches requires overlapping expression of L-selectin and β7 integrin. J Immunol. 1998;161:6638–6647
- . The human peripheral lymph node vascular addressin. An inducible endothelial antigen involved in lymphocyte homing. Am J Pathol. 1993;143:1688–1698
- Role of a sialyl Lewisx-like epitope selectively expressed on vascular endothelial cells in local skin inflammation of the rat. J Immunol. 1997;158:5384–5392
- . High endothelial venules present in lymphoid cell accumulations in thyroids affected by autoimmune disease: a study in men and BB rats of functional activity and development. J Clin Endocrin Metabol. 1989;68:744–751
- A HEV-restricted sulfotransferase is expressed in rheumatoid arthritis synovium and is induced by lymphotoxin-α/β and TNF-α in cultured endothelial cells. BMC Immunol. 2005;6:6–15
- Vascular addressins are induced on islet vessels during insulitis in nonobese diabetic mice and are involved in lymphoid binding to islet endothelium. J Clin Invest. 1993;92:2509–2515
- . Therapeutic targeting of endothelial ligands for L-selectin (PNAd) in a sheep model of asthma. Am J Pathol. 2005;166:935–944
- Leukocyte adhesion molecule-1 (LAM-1, L-selectin) interacts with an inducible endothelial cell ligand to support leukocyte adhesion. J Immunol. 1991;147:2565–2573
- . The cutaneous lymphocyte antigen (CLA) is an essential component of the L-selectin ligand induced in human vascular endothelial cells. J Exp Med. 1999;189:241–252
- . P-selectin glycoprotein ligand-1 is a ligand for L-selectin on neutrophils, monocytes, and CD34+ hematopoietic progenitor cells. J Cell Biol. 1996;135:523–531
- . Importance of primary capture and L-selectin-dependent secondary capture in leukocyte accumulation in inflammation and artherosclerosis in vivo. J Exp Med. 2001;194:205–218
- . Ligation of L-selectin through conserved regions within the lectin domain activates signal transduction pathways and integrin function in human, mouse, and rat leukocytes. J Immunol. 1997;159:952–963
- . Ligation of L-selectin on T lymphocytes activates β1 integrins and promotes adhesion to fibronectin. J Immunol. 1997;159:3498–3507
- . L-selectin facilitates emigration and extravascular locomotion of leukocytes during acute inflammatory responses in vivo. J Immunol. 2000;165:7164–7170
- Synergy between L-selectin signaling and chemotactic activation during neutrophil adhesion and transmigration. J Immunol. 1997;159:4566–4577
- . L-selectin enhances functional expression of surface CXCR4 in lymphocytes: implication for cellular activation during adhesion and migration. Blood. 2003;101:4245–4252
- . Immune surveillance in the skin: mechanisms and clinical consequences. Nat Rev Immunol. 2004;4:211–222
- . E-selectin, thymus- and activation-regulated chemokine/CCL17, and intercellular adhesion molecule-1 are constitutively coexpressed in dermal microvessels: a foundation for a cutaneous immunosurveillance system. J Immunol. 2004;172:1575–1581
- The vast majority of CLA+ T cells are resident in normal skin. J Immunol. 2006;176:4431–4439
- Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in E-selectin and P-selectin double mutant mice. J Exp Med. 1996;183:2329–2336
- . L-selectin is involved in lymphocyte migration to sites of inflammation in the skin: delayed rejection of allografts in L-selectin-deficient mice. J Immunol. 1997;158:5191–5199
- . Leukocyte entry into sites of inflammation requires overlapping interactions between the L-selectin and intercellular adhesion molecule-1 pathways. J Immunol. 1999;163:2176–2186
- . L-selectin deficient mice have impaired leukocyte recruitment into inflammatory sites. J Exp Med. 1995;181:2259–2264
- L-selectin or ICAM-1 deficiency reduces an immediate-type hypersensitivity response by preventing mast cell recruitment in repeated elicitation of contact hypersensitivity. J Immunol. 2003;170:4325–4334
- The cutaneous reverse arthus reaction requires intercellular adhesion molecule 1 and L-selectin expression. J Immunol. 2002;168:2970–2978
- Delayed wound healing in the absence of intercellular adhesion molecule-1 or L-selectin expression. Am J Pathol. 2000;157:237–247
- Endothelial selectins regulate skin wound healing in cooperation with L-selectin and ICAM-1. J Leukoc Biol. 2007;82:519–531
- . A critical role for transforming growth factor-β but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RBlow CD4+ T cells. J Exp Med. 1996;183:2669–2674
- . An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J Exp Med. 1999;190:995–1003
- Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cells. J Exp Med. 2004;199:303–313
- . CD25+CD4+ regulatory T cell migration requires L-selectin expression: L-selectin transcriptional regulation balances constitutive receptor turnover. J Immunol. 2007;178:291–300
- . IL-15 and dermal fibroblasts induce proliferation of natural regulatory T cells isolated from human skin. Blood. 2007;109:194–202
- . CD4+ T cells regulate CD8+ T cell-mediated cutaneous immune responses by restricting effector T cell development through a Fas ligand-dependent mechanism. J Immunol. 2004;172:2286–2295
- Migration matters: regulatory T cell compartmentalization determines supressive activity in vivo. Blood. 2005;106:3097–3104
- . CD4+CD25+ regulatory T cells suppress contact hypersensitivity reactions through a CD39, adenosine-dependent mechanism. J Allergy Clin Immunol. 2009;123:1287–1296
- . Dendritic cell antigen presentation drives simultaneous cytokine production by effector and regulatory T cells in inflamed skin. Immunity. 2009;30:277–288
- CD4+CD25+ regulatory T cells suppress mast cell degranulation and allergic responses through OX40-OX40L interaction. Immunity. 2008;29:771–781
- . Foxp3+ regulatory T cells maintain immune homeostasis in the skin. J Exp Med. 2008;205:1559–1565
- . Maintaining the norm: T-cell homeostasis. Nat Rev Immunol. 2002;2:547–556
- Interleukin 7 signaling in dendritic cells regulates the homeostatic proliferation and niche size of CD4+ T cells. Nat Immunol. 2009;10:149–157
- . Naive T cells transiently acquire a memory-like phenotype during homeostasis-driven proliferation. J Exp Med. 2000;192:557–564
- . Homeostasis-stimulated proliferation drives naive T cells to differentiate directly into memory T cells. J Exp Med. 2000;192:549–556
- Homeostatic proliferation of lymphocytes results in augmented memory-like function and accelerated allograft rejection. J Immunol. 2008;180:3910–3918
- . T lymphocyte migration to lymph nodes is maintained during homeostatic proliferation. Microsc Microanal. 2008;14:211–224
- . Homeostatic expansion of T cells during immune insufficiency generates autoimmunity. Cell. 2004;117:265–277
- CD4 T cells, lymphopenia, and IL-7 in a multistep pathway to autoimmunity. Proc Natl Acad Sci USA. 2008;105:2999–3004
- . A ligand for the chemokine receptor CCR7 can influence the homeostatic proliferation of CD4 T cells and progression of autoimmunity. J Immunol. 2001;167:6724–6730
- Novel synthetic inhibitors of selectin-mediated cell adhesion: synthesis of 1,6-bis[3-(3-carboxymethylphenyl)-4-(2-α-d-mannopyranosyloxy)phenyl]-hexane (TBC-1269). J Med Chem. 1998;41:1099–1111
- . Inhibition of adhesion of human neutrophils and eosinophils to P-selectin by the sialyl Lewis(x) antagonist TBC-1269. Preferential activity against neutrophil adhesion in vitro. J Allergy Clin Immunol. 2000;105:769–775
- . The anti-inflammatory effects of a selectin ligand mimetic, TBC-1269, are not a result of competitive inhibition of leukocyte rolling in vivo. J Leukoc Biol. 2005;77:59–66
- . Bimosiamose, an inhaled small-molecule pan-selectin antagonist, attenuates late asthmatic reactions following allergen challenge in mild asthmatics: a randomized, double-blind, placebo-controlled clinical cross-over-trial. Pulm Pharmacol Ther. 2006;19:233–241
- . Effect of a single dose of the selectin inhibitor TBC1269 on early and late asthmatic responses. Clin Exp Allergy. 2004;34:77–84
- Pan-selectin antagonism improves psoriasis manifestation in mice and man. Arch Dermatol Res. 2006;297:345–351
- . Anti-L-selectin antibody treatment of hemorrhagic-traumatic shock in baboons. Crit Care Med. 1999;27:1900–1907
- The effect of anti-L-selectin (aselizumab) in multiple traumatized patients-results of a phase II clinical trial. Crit Care Med. 2004;32:2021–2028
- . Leukocyte rolling and extravasation are severely compromised in P-selectin-deficient mice. Cell. 1993;74:541–554
- . Selective requirements for leukocyte adhesion molecules in models of acute and chronic cutaneous inflammation: participation of E- and P- but not L-selectin. Blood. 1999;93:580–589
- . Inhibition of delayed-type contact hypersensitivity in mice deficient in both E-selectin and P-selectin. Blood. 1996;88:2973–2979
- . Reduced recruitment of inflammatory cells in a contact hypersensitivity response in P-selectin-deficient mice. J Exp Med. 1995;181:2277–2282
- Role of endothelial selectins in wound repair. Am J Pathol. 1997;150:1701–1709
- Characterization of E-selectin-deficient mice: demonstration of overlapping function of the endothelial selectins. Immunity. 1994;1:709–720
PII: S0923-1811(09)00294-1
doi: 10.1016/j.jdermsci.2009.10.001
© 2009 Japanese Society for Investigative Dermatology. Published by Elsevier Inc. All rights reserved.
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Journal of Dermatological Science
Article in Press
