Journal of Dermatological Science
Volume 58, Issue 1 , Pages 8-18 , April 2010

Systematic evaluations of skin damage irradiated by an erbium:YAG laser: Histopathologic analysis, proteomic profiles, and cellular response

  • Tai-Long Pan

      Affiliations

    • School of Traditional Chinese Medicine, Chang Gung University, Kweishan, Taoyuan, Taiwan
    • ,
  • Pei-Wen Wang

      Affiliations

    • School of Traditional Chinese Medicine, Chang Gung University, Kweishan, Taoyuan, Taiwan
    • ,
  • Wan-Ruoh Lee

      Affiliations

    • Department of Dermatology, Taipei Medical University-Shuang-Ho Hospital, Taipei, Taiwan
    • Graduate Institute of Clinical Medicine, Taipei Medical University, Taipei, Taiwan
    • ,
  • Chia-Lang Fang

      Affiliations

    • Department of Pathology, Taipei Medical University, Taipei, Taiwan
    • ,
  • Chih-Chieh Chen

      Affiliations

    • Pharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung University, Kweishan, Taoyuan, Taiwan
    • ,
  • Chun-Ming Huang

      Affiliations

    • Division of Dermatology, Department of Medicine, University of California, San Diego, CA, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 858 552 8585x3708.
    • ,
  • Jia-You Fang

      Affiliations

    • Pharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung University, Kweishan, Taoyuan, Taiwan
    • Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
    • Corresponding Author InformationCorresponding author at: Graduate Institute of Natural Products, Chang Gung University, 259 Wen-Hwa 1st Road, Kweishan, Taoyuan 333, Taiwan. Tel.: +886 3 2118800x5521; fax: +886 3 2118236.

Received 11 September 2009 ,Revised 15 January 2010 ,Accepted 4 February 2010.

References 

  1. Fitzpatrick RE. Maximizing benefits and minimizing risk with CO2 laser resurfacing. Dermatol Clin. 2002;20:77–86
  2. Sapijaszko MJA, Zachary CB. Er:YAG laser skin resurfacing. Dermatol Clin. 2002;20:87–96
  3. Tanzi EL, Alster TS. Single-pass carbon dioxide versus multiple-pass Er:YAG laser skin resurfacing: a comparison of postoperative wound healing and side-effect rates. Dermatol Surg. 2003;29:80–84
  4. Polnikorn N, Goldberg DJ, Suwanchinda A, Ng SW. Erbium:YAG laser resurfacing in Asians. Dermatol Surg. 1998;24:1303–1307
  5. Caniglia RJ. Erbium:YAG laser skin resurfacing. Facial Plast Surg Clin N Am. 2004;12:373–377
  6. Lee WR, Shen SC, Wang KH, Hu CH, Fang JY. Lasers and microdermabrasion enhance and control topical delivery of vitamin C. J Invest Dermatol. 2003;121:1118–1125
  7. Lee WR, Pan TL, Wang PW, Zhuo RZ, Huang CM, Fang JY. Erbium:YAG laser enhances transdermal peptide delivery and skin vaccination. J Control Release. 2008;128:200–208
  8. Lee WR, Shen SC, Zhuo RZ, Wang KC, Fang JY. Enhancement of topical small interfering RNA delivery and expression by low-fluence erbium:YAG laser pretreatment of skin. Hum Gene Ther. 2009;20:580–588
  9. Singer DD, Singer AJ, McClain SA, Tortora G. Histologic effects of laser-assisted topical anesthesia in a porcine model. Acad Emerg Med. 2005;12:1148–1152
  10. Ko NY, Ahn HH, Kim SN, Kye YC. Analysis of erythema after Er:YAG laser resurfacing. Dermatol Surg. 2007;33:1322–1327
  11. Chan HHL, Yang CH, Leung JCK, Wei WI, Lai KN. An animal study of the effects on p16 and PCNA expression of repeated treatment with high-energy laser and intense pulsed light exposure. Laser Surg Med. 2007;39:8–13
  12. Smith KJ, Skelton HG, Graham JS, Hamilton TA, Hackley BE, Hurst CG. Depth of morphologic skin damage and viability after one, two, and three passes of a high-energy, short-pulse CO2 laser (Tru-Pulse) in pig skin. J Am Acad Dermatol. 1997;37:204–210
  13. Wang PW, Chang WN, Lu CH, Chao D, Schrag C, Pan TL. New insights into the pathological mechanisms of cerebrotendinous xanthomatosis in the Taiwanese using genomic and proteomic tools. Proteomics. 2006;6:1029–1037
  14. Lubec G, Afjehi-Sadat L, Yang JW, John JP. Searching for hypothetical proteins: theory and practice based upon original data and literature. Prog Neurobiol. 2005;77:90–127
  15. Doukas AG, Kollias N. Transdermal drug delivery with a pressure wave. Adv Drug Deliv Rev. 2004;56:559–579
  16. Sviridov AP, Zimnyakov DA, Sinichkin YP, Butvina LN, Omelchenko AJ, Shakh GS, et al. Attenuated total reflection Fourier transform infrared and polarization spectroscopy of in vivo human skin ablated, layer by layer, by erbium:YAG laser. J Biomed Opt. 2004;9:820–827
  17. Chilcott RP, Dalton CH, Emmanuel AJ, Allen CE, Bradley ST. Transepidermal water loss does not correlate with skin barrier function in vitro. J Invest Dermatol. 2002;118:871–875
  18. Chen B, Thomsen SL, Thomas RJ, Oliver J, Welch AJ. Histological and modeling study of skin thermal injury to 2.0μm laser irradiation. Laser Surg Med. 2008;40:358–370
  19. Kim YJ, Lee HS, Son SW, Kim SN, Kye YC. Analysis of hyperpigmentation and hypopigmentation after Er:YAG laser resurfacing. Laser Surg Med. 2005;36:47–51
  20. Rajan P, Grimes PE. Skin barrier changes induced by aluminum oxide and sodium chloride microdermabrasion. Dermatol Surg. 2002;28:390–393
  21. Menon GK, Kollias N, Doukas AG. Ultrastructural evidence of stratum corneum permeabilization induced by photomechanical waves. J Invest Dermatol. 2003;121:104–109
  22. Fukuda Y, Ito Y, Azumi H, Eid NAS, Li ZL, Marumo M, et al. Cell death and proliferation in Nd–YAG laser, electrocautery, and scalpel wounds on mice skin. J Dermatol Sci. 2002;28:106–118
  23. Drnovšek-Olup B, Beltram M, Pižem J. Repetitive Er:YAG laser irradiation of human skin: a histological evaluation. Laser Surg Med. 2004;35:146–151
  24. Oender K, Trost A, Lanschuetzer C, Laimer M, Emberger M, Breitenbach M, et al. Cytokeratin-related loss of cellular integrity is not a major driving force of human intrinsic skin aging. Mech Ageing Dev. 2008;129:563–571
  25. Porter RM, Leitgeb S, Melton DW, Swensson O, Eady RAJ, Magin TM. Gene targeting at the mouse cytokeratin 10 locus: severe skin fragility and changes of cytokeratin expression in the epidermis. J Cell Biol. 1996;132:925–936
  26. Ouhtit A, Muller HK, Davis DW, Ullrich SE, McConkey D, Ananthaswamy HN. Temporal events in skin injury and the early adaptive responses in ultraviolet-irradiated mouse skin. Am J Pathol. 2000;156:201–207
  27. Pozner JN, Goldberg DJ. Superficial erbium:YAG laser resurfacing of photodamaged skin. J Cosmet Laser Ther. 2006;8:89–91
  28. Avram DK, Goldman MP. The safety and effectiveness of single-pass erbium:YAG laser in the treatment of mild to moderate photodamage. Dermatol Surg. 2004;30:1073–1076
  29. Medina A, Ghaffari A, Kilani RT, Ghahary A. The role of stratifin in fibroblast–keratinocyte interaction. Mol Cell Biochem. 2007;305:255–264
  30. He TC, Sparks AB, Rago C, Hermeking H. Identification of c-MYC as a target of the APC pathway. Science. 1998;281:1509–1512
  31. Dellambra E, Golisano O, Bondanza S, Siviero E. Downregulation of 14-3-3 sigma prevents clonal evolution and leads to immortalization of primary human keratinocytes. J Cell Biol. 2000;149:1117–1130
  32. Ghahary A, Marcoux Y, Karimi-Busheri F, Li Y, Tredget EE, Kilani RT, et al. Differentiated keratinocyte-releasable stratifin (14-3-3 sigma) stimulates MMP-1 expression in dermal fibroblasts. J Invest Dermatol. 2005;124:170–177
  33. Kilani RT, Medina A, Aitken A, Jalili RB, Carr M, Ghahary A. Identification of different isoforms of 14-3-3 protein family in human dermal and epidermal layers. Mol Cell Biochem. 2008;314:161–169
  34. Chen W, Kang J, Xia J, Li Y, Yang B, Chen B, et al. Bi Z. p53-related apoptosis resistance and tumor suppression activity in UVB-induced premature senescent human skin fibroblasts. Int J Mol Med. 2008;21:645–653
  35. El-Domyati MM, Attia SK, Esmat AM, Ahmad HM, Abdel Wahab HM, Badr BM. Effect of laser resurfacing on p53 expression in photoaged facial skin. Dermatol Surg. 2007;33:668–675
  36. Bailet O, Fenouille N, Abbe P, Robert G, Rocchi S, Gonthier N, et al. Spleen tyrosine kinase functions as a tumor suppressor in melanoma cells by inducing senescence-like growth arrest. Cancer Res. 2009;69:2748–2756
  37. Wang JW, Peng SY, Li JT, Wang Y, Zhang ZP, Cheng Y, et al. Identification of metastasis-associated proteins involved in gallbladder carcinoma metastasis by proteomic analysis and functional exploration of chloride intracellular channel 1. Cancer Lett. 2009;281:71–81
  38. Duverger O, Morange M. Heat shock protein 25 plays multiple roles during mouse skin development. Cell Stress Chaperones. 2005;10:268–277
  39. Schallreuter KU, Behrens-Williams S, Khaliq TP, Picksley SM, Peters EMJ, Marles LK, et al. Increased epidermal functioning wild-type p53 expression in vitiligo. Exp Dermatol. 2003;12:268–277
  40. El-Abaseri TB, Putta S, Hansen LA. Ultraviolet irradiation induces keratinocyte proliferation and epidermal hyperplasia through the activation of the epidermal growth factor receptor. Carcinogenesis. 2006;27:225–231

PII: S0923-1811(10)00045-9

doi: 10.1016/j.jdermsci.2010.02.001

Journal of Dermatological Science
Volume 58, Issue 1 , Pages 8-18 , April 2010

Article Tools

* Image Usage & Resolution