Journal of Dermatological Science
Volume 58, Issue 1 , Pages 43-54 , April 2010

Laminin-511, inducer of hair growth, is down-regulated and its suppressor in hair growth, laminin-332 up-regulated in chemotherapy-induced alopecia

  • Hisayoshi Imanishi

      Affiliations

    • Department of Dermatology Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan
  • ,
  • Daisuke Tsuruta

      Affiliations

    • Department of Dermatology Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 6 6645 3826; fax: +81 6 6645 3828.
  • ,
  • Chiharu Tateishi

      Affiliations

    • Department of Dermatology Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan
  • ,
  • Koji Sugawara

      Affiliations

    • Department of Dermatology Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan
    • Department of Dermatology, University Hospital Schleswig-Holstein, University of Lübeck, Lübeck, Germany
  • ,
  • Ralf Paus

      Affiliations

    • Department of Dermatology, University Hospital Schleswig-Holstein, University of Lübeck, Lübeck, Germany
  • ,
  • Tsutomu Tsuji

      Affiliations

    • Department of Microbiology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan
  • ,
  • Masamitsu Ishii

      Affiliations

    • Department of Dermatology Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan
  • ,
  • Kazuo Ikeda

      Affiliations

    • Department of Functional Anatomy, Nagoya City University Graduate School of Medicine, Nagoya, Japan
  • ,
  • Hiroyuki Kunimoto

      Affiliations

    • Department of Immunology, Osaka City University Graduate School of Medicine, Osaka, Japan
  • ,
  • Koichi Nakajima

      Affiliations

    • Department of Immunology, Osaka City University Graduate School of Medicine, Osaka, Japan
  • ,
  • Jonathan C.R. Jones

      Affiliations

    • Department of Cell and Molecular Biology, Northwestern University Graduate School of Medicine, Chicago, IL, Japan
  • ,
  • Hiromi Kobayashi

      Affiliations

    • Department of Dermatology Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan

Received 5 August 2009 ,Revised 26 January 2010 ,Accepted 8 February 2010.

References 

  1. Sausville EA, Longo DL. In: 17th ed..  Fauci AS,  Braunwald E,  Kasper DL,  Hauser SL,  Longo DL,  Jameson JL, et al. editor. Principles of cancer treatment. Harrison's principles of internal medicine. vol. 1:New York: McGraw-Hill; 2008;p. 514–533
  2. Hashimoto T, Ito M. Drug-induced alopecia. In:  Tamaki K editors. Comprehensive handbook of clinical dermatology. vol. 17:Tokyo: Nakayamashoten; 2002;p. 45–52
  3. Cece R, Cazzaniga S, Morelli D, Sfondrini L, Bignotto M, Menard S, et al. Apoptosis of hair follicle cells during doxorubicin-induced alopecia in rats. Lab Invest. 1996;75:601–609
  4. Müller-Röver S, Rossiter H, Lindner G, Peters EM, Kupper TS, Paus R. Hair follicle apoptosis and bcl-2. J Investig Dermatol Symp Proc. 1999;4:272–277
  5. Schilli MB, Paus R, Menrad A. Reduction of intrafollicular apoptosis in chemotherapy-induced alopecia by topical calcitriol-analogs. J Invest Dermatol. 1998;111:598–604
  6. Takahata K, Tada M, Yazawa K, Tamaki T. Protection from chemotherapy-induced alopecia by docosahexaenoic acid. Lipids. 1999;34(Suppl.):S105
  7. Paus R, Handjiski B, Eichmüller S, Czarnetzki BM. Chemotherapy-induced alopecia in mice. Induction by cyclophosphamide, inhibition by cyclosporine a, and modulation by dexamethasone. Am J Pathol. 1994;144:719–734
  8. Sullivan RD, Mescon H, Jones R. The effect of intra-arterial nitrogen-mustard therapy on human skin. Cancer. 1953;6:288–293
  9. Hendrix S, Handjiski B, Peters EM, Paus R. A guide to assessing damage response pathways of the hair follicle: Lessons from cyclophosphamide-induced alopecia in mice. J Invest Dermatol. 2005;125:42–51
  10. Perez JE, Macchiavelli M, Leone BA, Romero A, Rabinovich MG, Goldar D, et al. High-dose alpha-tocopherol as a preventive of doxorubicin-induced alopecia. Cancer Treat Rep. 1986;70:1213–1214
  11. Wood LA. Possible prevention of adriamycin-induced alopecia by tocopherol. N Engl J Med. 1985;312:1060
  12. Martin-Jimenez M, Diaz-Rubio E, Gonzalez Larriba JL, Sangro B. Failure of high-dose tocopherol to prevent alopecia induced by doxorubicin. N Engl J Med. 1986;315:894–895
  13. Duvic M, Lemak NA, Valero V, Hymes SR, Farmer KL, Hortobagyi GN, et al. A randomized trial of minoxidil in chemotherapy-induced alopecia. J Am Acad Dermatol. 1996;35:74–78
  14. Granai CO, Frederickson H, Gajewski W, Goodman A, Goldstein A, Baden H. The use of minoxidil to attempt to prevent alopecia during chemotherapy for gynecologic malignancies. Eur J Gynaecol Oncol. 1991;12:129–132
  15. Rodriguez R, Machiavelli M, Leone B, Romero A, Cuevas MA, Langhi M, et al. Minoxidil (mx) as a prophylaxis of doxorubicin--induced alopecia. Ann Oncol. 1994;5:769–770
  16. Gregory RP, Cooke T, Middleton J, Buchanan RB, Williams CJ. Prevention of doxorubicin-induced alopedia by scalp hypothermia: Relation to degree of cooling. Br Med J (Clin Res Ed). 1982;284:1674
  17. Tollenaar RA, Liefers GJ, Repelaer van Driel OJ, van de Velde CJ. Scalp cooling has no place in the prevention of alopecia in adjuvant chemotherapy for breast cancer. Eur J Cancer. 1994;30A:1448–1453
  18. Sugawara K, Tsuruta D, Kobayashi H, Ikeda K, Hopkinson SB, Jones JC, et al. Spatial and temporal control of laminin-332 (5) and -511 (10) expression during induction of anagen hair growth. J Histochem Cytochem. 2007;55:43–55
  19. Li J, Tzu J, Chen Y, Zhang YP, Nguyen NT, Gao J, et al. Laminin-10 is crucial for hair morphogenesis. EMBO J. 2003;22:2400–2410
  20. Gao J, DeRouen MC, Chen CH, Nguyen M, Nguyen NT, Ido H, et al. Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis. Genes Dev. 2008;22:2111–2124
  21. Langhofer M, Hopkinson SB, Jones JC. The matrix secreted by 804g cells contains laminin-related components that participate in hemidesmosome assembly in vitro. J Cell Sci. 1993;105(Pt 3):753–764
  22. DiPersio CM, Shah S, Hynes RO. Alpha 3a beta 1 integrin localizes to focal contacts in response to diverse extracellular matrix proteins. J Cell Sci. 1995;108(Pt 6):2321–2336
  23. Miner JH, Patton BL, Lentz SI, Gilbert DJ, Snider WD, Jenkins NA, et al. The laminin alpha chains: expression, developmental transitions, and chromosomal locations of alpha1-5, identification of heterotrimeric laminins 8-11, and cloning of a novel alpha3 isoform. J Cell Biol. 1997;137:685–701
  24. Tiger CF, Champliaud MF, Pedrosa-Domellof F, Thornell LE, Ekblom P, Gullberg D. Presence of laminin alpha5 chain and lack of laminin alpha1 chain during human muscle development and in muscular dystrophies. J Biol Chem. 1997;272:28590–28595
  25. Fessing MY, Sharova TY, Sharov AA, Atoyan R, Botchkarev VA. Involvement of the edar signaling in the control of hair follicle involution (catagen). Am J Pathol. 2006;169:2075–2084
  26. Bodó E, Tobin DJ, Kamenisch Y, Biró T, Berneburg M, Funk W, et al. Dissecting the impact of chemotherapy on the human hair follicle: A pragmatic in vitro assay for studying the pathogenesis and potential management of hair follicle dystrophy. Am J Pathol. 2007;171:1153–1167
  27. Philpott MP, Green MR, Kealey . T Human hair growth in vitro. J Cell Sci. 1990;97(Pt 3):463–471
  28. Peters EM, Liotiri S, Bodó E, Hagen E, Biró T, Arck PC, et al. Probing the effects of stress mediators on the human hair follicle: substance p holds central position. Am J Pathol. 2007;171:1872–1886
  29. Telek A, Biró T, Bodó E, Toth BI, Borbiro I, Kunos G, et al. Inhibition of human hair follicle growth by endo- and exocannabinoids. FASEB J. 2007;21:3534–3541
  30. Rooney JE, Gurpur PB, Burkin DJ. Laminin-111 protein therapy prevents muscle disease in the mdx mouse model for duchenne muscular dystrophy. Proc Natl Acad Sci U S A. 2009;106:7991–7996
  31. Kato T, Katabami K, Takatsuki H, Han SA, Takeuchi K, Irimura T, et al. Characterization of the promoter for the mouse alpha 3 integrin gene. Eur J Biochem. 2002;269:4524–4532
  32. Tateishi C, Tsuruta D, Sugawara K, Imanishi H, Nishida K, Ishii M, et al. Spatial and temporal control of laminin-511 and -332 expressions during catagen. J Cell Sci (in press).
  33. Botchkarev VA, Komarova EA, Siebenhaar F, Botchkareva NV, Komarov PG, Maurer M, et al. P53 is essential for chemotherapy-induced hair loss. Cancer Res. 2000;60:5002–5006
  34. Davis ST, Benson BG, Bramson HN, Chapman DE, Dickerson SH, Dold KM, et al. Prevention of chemotherapy-induced alopecia in rats by cdk inhibitors. Science. 2001;291:134–137
  35. Sharov AA, Siebenhaar F, Sharova TY, Botchkareva NV, Gilchrest BA, Botchkarev VA. Fas signaling is involved in the control of hair follicle response to chemotherapy. Cancer Res. 2004;64:6266–6270
  36. Müller-Röver S, Rossiter H, Paus R, Handjiski B, Peters EM, Murphy JE, et al. Overexpression of bcl-2 protects from ultraviolet b-induced apoptosis but promotes hair follicle regression and chemotherapy-induced alopecia. Am J Pathol. 2000;156:1395–1405
  37. Frisch SM, Francis H. Disruption of epithelial cell-matrix interactions induces apoptosis. J Cell Biol. 1994;124:619–626
  38. Conti FJ, Rudling RJ, Robson A, Hodivala-Dilke KM. Alpha3beta1-integrin regulates hair follicle but not interfollicular morphogenesis in adult epidermis. J Cell Sci. 2003;116:2737–2747

PII: S0923-1811(10)00049-6

doi: 10.1016/j.jdermsci.2010.02.005

Journal of Dermatological Science
Volume 58, Issue 1 , Pages 43-54 , April 2010