Journal of Dermatological Science
Volume 59, Issue 1 , Pages 50-52 , July 2010

A single nucleotide polymorphism of MHC region is associated with subphenotypes of Psoriasis in Chinese population

  • Hou-Feng Zheng

      Affiliations

    • Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China
    • Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, China, Hefei, Anhui 230022, China
    • These authors contributed equally to this work.
    • ,
  • Chi Zhang

      Affiliations

    • Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China
    • Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, China, Hefei, Anhui 230022, China
    • These authors contributed equally to this work.
    • ,
  • Liang-Dan Sun

      Affiliations

    • Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China
    • Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, China, Hefei, Anhui 230022, China
    • These authors contributed equally to this work.
    • ,
  • Cheng Ni

      Affiliations

    • Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China
    • Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, China, Hefei, Anhui 230022, China
    • These authors contributed equally to this work.
  • Zheng Zhang

      Affiliations

    • Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China
    • Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, China, Hefei, Anhui 230022, China
    • ,
  • Wen-Sheng Lu

      Affiliations

    • Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China
    • Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, China, Hefei, Anhui 230022, China
    • ,
  • Sheng-Xin Xu

      Affiliations

    • Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China
    • Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, China, Hefei, Anhui 230022, China
    • ,
  • Jian-Wen Han

      Affiliations

    • Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China
    • Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, China, Hefei, Anhui 230022, China
    • ,
  • Hui Cheng

      Affiliations

    • Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China
    • Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, China, Hefei, Anhui 230022, China
    • ,
  • Kun-Ju Zhu

      Affiliations

    • Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China
    • Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, China, Hefei, Anhui 230022, China
  • Sen Yang

      Affiliations

    • Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China
    • Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, China, Hefei, Anhui 230022, China
  • Xue-Jun Zhang

      Affiliations

    • Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China
    • Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, China, Hefei, Anhui 230022, China
    • Corresponding Author InformationCorresponding author at: Institute of Dermatology, Anhui Medical University, No. 81, Meishan Road, Hefei, Anhui 230032, China. Tel.: +86 551 5161002; fax: +86 551 5161016.

Received 15 December 2009

References 

  1. Shao CG. The prevalence, prevention and treatment of psoriasis in china. Chin J Dermatol. 1996;29:75–76
  2. Zhang X, Wang H, Te-Shao H, Yang S, Chen S. The genetic epidemiology of psoriasis vulgaris in Chinese Han. Int J Dermatol. 2002;41:663–669
  3. Zhang XJ, Huang W, Yang S, Sun LD, Zhang FY, Zhu QX, et al. Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21. Nat Genet. 2009;41:205–210
  4. Langley RG, Ellis CN. Evaluating psoriasis with Psoriasis Area and Severity Index, Psoriasis Global Assessment, and Lattice System Physician's Global Assessment. J Am Acad Dermatol. 2004;51:563–569
  5. de Bakker PI, McVean G, Sabeti PC, Miretti MM, Green T, Marchini J, et al. A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. Nat Genet. 2006;38:1166–1172
  6. Mallon E, Bunce M, Savoie H, Rowe A, Newson R, Gotch F, et al. HLA-C and guttate psoriasis. Br J Dermatol. 2000;143:1177–1182
  7. Fan X, Yang S, Sun LD, Liang YH, Gao M, Zhang KY, et al. Comparison of clinical features of HLA-Cw*0602-positive and -negative psoriasis patients in a Han Chinese population. Acta Derm Venereol. 2007;87:335–340

PII: S0923-1811(10)00084-8

doi: 10.1016/j.jdermsci.2010.03.006

Journal of Dermatological Science
Volume 59, Issue 1 , Pages 50-52 , July 2010

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