Journal of Dermatological Science
Volume 59, Issue 1 , Pages 52-55 , July 2010

HaCaT keratinocytes express functional receptors for thyroid-stimulating hormone

  • Ralf Paus

      Affiliations

    • The University of Manchester, Manchester Academic Health Science Centre, Epithelial Science Research Group, School of Translational Medicine, Stopford Building, Oxford Road, Manchester M13 9PT, UK
    • Department of Dermatology, University of Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany

Received 4 September 2009

References 

  1. Slominski A, Wortsman J, Tuckey RC, Paus R. Differential expression of HPA axis homolog in the skin. Mol Cell Endocrinol. 2007;265–266:143–149
  2. Ito N, Ito T, Kromminga A, Bettermann A, Takigawa M, Kees F, et al. Human hair follicles display a functional equivalent of the hypothalamic–pituitary–adrenal axis and synthesize cortisol. FASEB J. 2005;19:1332–1334
  3. Bodó E, Kromminga A, Bíró T, Borbíró I, Gáspár E, Zmijewski MA, et al. Human female hair follicles are a direct, nonclassical target for thyroid-stimulating hormone. J Invest Dermatol. 2009;129:1126–1139
  4. Cianfarani F, Baldini E, Cavalli A, Marchioni E, Lembo L, Teson M, et al. TSH receptor and thyroid-specific gene expression in human skin. J Invest Dermatol. 2009;July 30 [Epub ahead of print]
  5. Slominski A, Wortsman J, Kohn L, Ain KB, Venkataraman GM, Pisarchik A, et al. Expression of hypothalamic–pituitary–thyroid axis related genes in the human skin. J Invest Dermatol. 2002;119:1449–1455
  6. Cooper DS. Subclinical hypothyroidism. N Engl J Med. 2001;345:260–265
  7. Meyer KC, Klatte JE, Dinh HV, Harries MJ, Reithmayer K, Meyer W, et al. Evidence that the bulge region is a site of relative immune privilege in human hair follicles. Br J Dermatol. 2008;159(November (5)):1077–1085
  8. Davies T, Marians R, Latif R. The TSH receptor reveals itself. J Clin Invest. 2002;110:161–164
  9. Tuschil A, Lam C, Haslberger A, Lindley I. Interleukin-8 stimulates calcium transients and promotes epidermal cell proliferation. J Invest Dermatol. 1992;99:294–298

PII: S0923-1811(10)00128-3

doi: 10.1016/j.jdermsci.2010.04.007

Journal of Dermatological Science
Volume 59, Issue 1 , Pages 52-55 , July 2010