Journal of Dermatological Science
Volume 59, Issue 1 , Pages 55-57 , July 2010

The expression of TLR2, TLR4 and TLR9 in the epidermis of patients with cutaneous leishmaniasis

  • Felipe Francisco Tuon

      Affiliations

    • Corresponding Author InformationCorresponding author at: Infectious and Parasitic Diseases Clinic, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, Avenida Dr. Enéas de Carvalho Aguiar 255, 4° Andar, Sala 4028, ICHC, Cerqueira César, CEP 05403-010, São Paulo, Brazil. Tel.: +55 11 30696530; fax: +55 11 30697508.

Received 2 March 2010

References 

  1. Tuon FF, Amato VS, Bacha HA, Almusawi T, Duarte MI, Neto Amato V. Toll-like receptors and leishmaniasis. Infect Immun. 2008;76:866–872
  2. Miller LS. Toll-like receptors in skin. Adv Dermatol. 2008;24:71–87
  3. Amato VS, Tuon FF, de Andrade HF, Bacha H, Pagliari C, Fernandes ER, et al. Immunohistochemistry and polymerase chain reaction on paraffin-embedded material improve the diagnosis of cutaneous leishmaniasis in the Amazon region. Int J Dermatol. 2009;48:1091–1095
  4. Kollisch G, Kalali BN, Voelcker V, Wallich R, Behrendt H, Ring J, et al. Various members of the Toll-like receptor family contribute to the innate immune response of human epidermal keratinocytes. Immunology. 2005;114:531–541
  5. Lee YJ, Choi HJ, Kang TW, Kim HO, Chung MJ, Park YM. CBT-SL5, a bacteriocin from Enterococcus faecalis, suppresses the expression of interleukin-8 induced by Propionibacterium acnes in cultured human keratinocytes. J Microbiol Biotechnol. 2008;18:1308–1316
  6. Hawn TR, Ozinsky A, Underhill DM, Buckner FS, Akira S, Aderem A. Leishmania major activates IL-1 alpha expression in macrophages through a MyD88-dependent pathway. Microbes Infect. 2002;4:763–771
  7. Antoniazi S, Price HP, Kropf P, Freudenberg MA, Galanos C, Smith DF, et al. Chemokine gene expression in toll-like receptor-competent and -deficient mice infected with Leishmania major. Infect Immun. 2004;72:5168–5174
  8. Kavoosi G, Ardestani SK, Kariminia A. The involvement of TLR2 in cytokine and reactive oxygen species (ROS) production by PBMCs in response to Leishmania major phosphoglycans (PGs). Parasitology. 2009;136:1193–1199
  9. Pivarcsi A. Toll-like receptor 9-independent suppression of skin inflammation by oligonucleotides. J Invest Dermatol. 2007;127:746–748

☆ Note: The authors are not part of any associations or commercial relationships that might represent conflicts of interest in the writing of this study (e.g., pharmaceutical stock ownership, consultancy, advisory board membership, relevant patents, or research funding). This study was totally supported by FAPESP (Fundo de Amparo a Pesquisa do Estado de Sao Paulo).

PII: S0923-1811(10)00130-1

doi: 10.1016/j.jdermsci.2010.04.009

Journal of Dermatological Science
Volume 59, Issue 1 , Pages 55-57 , July 2010

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