Journal of Dermatological Science
Volume 59, Issue 2 , Pages 86-90 , August 2010

Erythropoietin promotes hair shaft growth in cultured human hair follicles and modulates hair growth in mice

  • Bo Mi Kang

      Affiliations

    • Department of Immunology, School of Medicine, Kyungpook National University, 101 Dong-In-Dong, Jung-Gu, Daegu 700-422, Republic of Korea
    • ,
  • Seung Hyun Shin

      Affiliations

    • Department of Immunology, School of Medicine, Kyungpook National University, 101 Dong-In-Dong, Jung-Gu, Daegu 700-422, Republic of Korea
    • ,
  • Mi Hee Kwack

      Affiliations

    • Department of Immunology, School of Medicine, Kyungpook National University, 101 Dong-In-Dong, Jung-Gu, Daegu 700-422, Republic of Korea
    • ,
  • HyeRim Shin

      Affiliations

    • Department of Immunology, School of Medicine, Kyungpook National University, 101 Dong-In-Dong, Jung-Gu, Daegu 700-422, Republic of Korea
    • ,
  • Ji Won Oh

      Affiliations

    • Department of Immunology, School of Medicine, Kyungpook National University, 101 Dong-In-Dong, Jung-Gu, Daegu 700-422, Republic of Korea
    • ,
  • Jinoh Kim

      Affiliations

    • Department of Immunology, School of Medicine, Kyungpook National University, 101 Dong-In-Dong, Jung-Gu, Daegu 700-422, Republic of Korea
    • ,
  • Chanil Moon

      Affiliations

    • Department of Cardiology, Gil Medical Center, Gachon University, 1198 Guwol-dong, Namdong-gu, Incheon 405-760, Republic of Korea
    • ,
  • Cheil Moon

      Affiliations

    • Department of Brain Science, Daegu Gyeongbuk Institute of Science & Technology, 1188 Dalgubeoldaero(St.), Jung-gu, Daegu 700-742, Republic of Korea
    • ,
  • Jung Chul Kim

      Affiliations

    • Department of Immunology, School of Medicine, Kyungpook National University, 101 Dong-In-Dong, Jung-Gu, Daegu 700-422, Republic of Korea
    • ,
  • Moon Kyu Kim

      Affiliations

    • Department of Immunology, School of Medicine, Kyungpook National University, 101 Dong-In-Dong, Jung-Gu, Daegu 700-422, Republic of Korea
    • Corresponding Author InformationCorresponding author. Tel.: +82 53 420 4876; fax: +82 53 423 4628.
    • ,
  • Young Kwan Sung

      Affiliations

    • Department of Immunology, School of Medicine, Kyungpook National University, 101 Dong-In-Dong, Jung-Gu, Daegu 700-422, Republic of Korea
    • Corresponding Author InformationCorresponding author. Tel.: +82 53 420 4874; fax: +82 53 423 4628.

Received 21 December 2009 ,Revised 26 April 2010 ,Accepted 27 April 2010.

References 

  1. Wen D, Boissel JP, Showers M, Ruch BC, Bunn HF. Erythropoietin structure–function relationships. Identification of functionally important domains. J Biol Chem. 1994;269:22839–22846
  2. Elliott S, Lorenzini T, Chang D, Barzilay J, Delorme E. Mapping of the active site of recombinant human erythropoietin. Blood. 1997;89:493–502
  3. Davis JM, Arakawa T, Strickland TW, Yphantis DA. Characterization of recombinant human erythropoietin produced in Chinese hamster ovary cells. Biochemistry. 1987;26:2633–2638
  4. Jelkmann W. Molecular biology of erythropoietin. Intern Med. 2004;43:649–659
  5. Miura Y, Miura O, Ihle JN, Aoki N. Activation of the mitogen-activated protein kinase pathway by the erythropoietin receptor. J Biol Chem. 1994;269:29962–29969
  6. Brines M, Cerami A. Discovering erythropoietin's extra-hematopoietic functions: biology and clinical promise. Kidney Int. 2006;70:246–250
  7. Hardy MH. The secret life of the hair follicle. Trends Genet. 1992;8:55–61
  8. Botchkarev VA, Kishimoto J. Molecular control of epithelial–mesenchymal interactions during hair follicle cycling. J Investig Dermatol Symp Proc. 2003;8:46–55
  9. Stenn KS, Paus R. Controls of hair follicle cycling. Physiol Rev. 2001;81:449–494
  10. LeBaron MJ, Ahonen TJ, Nevalainen MT, Rui H. In vivo response-based identification of direct hormone target cell populations using high-density tissue arrays. Endocrinology. 2007;148:989–1008
  11. Bodó E, Kromminga A, Funk W, Laugsch M, Duske U, Jelkmann W, et al. Human hair follicles are an extrarenal source and a nonhematopoietic target of erythropoietin. FASEB J. 2007;21:3346–3354
  12. Philpott MP, Sanders DA, Kealey T. Effects of insulin and insulin-like growth factors on cultured human hair follicles: IGF-1 at physiologic concentrations is an important regulator of hair follicle growth in vitro. J Invest Dermatol. 1994;102:857–861
  13. Magerl M, Kauser S, Paus R, Tobin DJ. Simple and rapid method to isolate and culture follicular papillae from human scalp hair follicles. Exp Dermatol. 2002;11:381–385
  14. Kwack MH, Sung YK, Chung EJ, Im SU, Ahn JS, Kim MK, et al. Dihydrotestosterone-inducible dickkopf 1 from balding dermal papilla cells causes apoptosis in follicular keratinocytes. J Invest Dermatol. 2008;128:262–269
  15. Kwack MH, Shin SH, Kim SR, Im SU, Han IS, Kim MK, et al. l-Ascorbic acid 2-phosphate promotes elongation of hair shafts via the secretion of insulin-like growth factor-1 from dermal papilla cells through phosphatidylinositol 3-kinase. Br J Dermatol. 2009;160:1157–1162
  16. Müller-Röver S, Handjiski B, van der Veen C, Eichmüller S, Foitzik K, McKay IA, et al. A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages. J Invest Dermatol. 2001;117:3–15
  17. Botchkarev VA, Botchkareva NV, Nakamura M, Huber O, Funa K, Lauster R, et al. Noggin is required for induction of the hair follicle growth phase in postnatal skin. FASEB J. 2001;15:2205–2214
  18. Elliott S, Busse L, Bass MB, Lu H, Sarosi I, Sinclair AM, et al. Anti-Epo receptor antibodies do not predict Epo receptor expression. Blood. 2006;107:1892–1895

PII: S0923-1811(10)00157-X

doi: 10.1016/j.jdermsci.2010.04.015

Journal of Dermatological Science
Volume 59, Issue 2 , Pages 86-90 , August 2010

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