Journal of Dermatological Science
Volume 59, Issue 2 , Pages 98-106 , August 2010

Identification and analysis of an early diagnostic marker for malignant melanoma: ZAR1 intra-genic differential methylation

  • Yui Shinojima

      Affiliations

    • Division of Cutaneous Science, Department of Dermatology, Nihon University Graduate School of Medicine, Tokyo, Japan
    • Division of Cancer Genetics, Department of Advanced Medical Research Center, Nihon University School of Medicine, Tokyo, Japan
    • ,
  • Tadashi Terui

      Affiliations

    • Division of Cutaneous Science, Department of Dermatology, Nihon University Graduate School of Medicine, Tokyo, Japan
    • ,
  • Hiroyuki Hara

      Affiliations

    • Division of Cutaneous Science, Department of Dermatology, Nihon University Graduate School of Medicine, Tokyo, Japan
    • ,
  • Makoto Kimura

      Affiliations

    • Life Science, Advanced Research Institute for the Science and Humanities, Nihon University, Tokyo, Japan
    • ,
  • Jun Igarashi

      Affiliations

    • Life Science, Advanced Research Institute for the Science and Humanities, Nihon University, Tokyo, Japan
    • ,
  • Xiaofei Wang

      Affiliations

    • Life Science, Advanced Research Institute for the Science and Humanities, Nihon University, Tokyo, Japan
    • ,
  • Hiroyuki Kawashima

      Affiliations

    • Division of Cancer Genetics, Department of Advanced Medical Research Center, Nihon University School of Medicine, Tokyo, Japan
    • ,
  • Yujin Kobayashi

      Affiliations

    • Division of Cancer Genetics, Department of Advanced Medical Research Center, Nihon University School of Medicine, Tokyo, Japan
    • ,
  • Satomi Muroi

      Affiliations

    • Division of Cancer Genetics, Department of Advanced Medical Research Center, Nihon University School of Medicine, Tokyo, Japan
    • ,
  • Satoshi Hayakawa

      Affiliations

    • Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan
    • ,
  • Mariko Esumi

      Affiliations

    • Department of Pathology, Nihon University School of Medicine, Tokyo, Japan
    • ,
  • Kyoko Fujiwara

      Affiliations

    • Division of Cancer Genetics, Department of Advanced Medical Research Center, Nihon University School of Medicine, Tokyo, Japan
    • Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY, USA
    • ,
  • Srimoyee Ghosh

      Affiliations

    • Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY, USA
    • ,
  • Tatsuo Yamamoto

      Affiliations

    • Department of Gynecology, Nihon University School of Medicine, Tokyo, Japan
    • ,
  • William Held

      Affiliations

    • Department of Molecular Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY, USA
    • ,
  • Hiroki Nagase

      Affiliations

    • Division of Cancer Genetics, Department of Advanced Medical Research Center, Nihon University School of Medicine, Tokyo, Japan
    • Life Science, Advanced Research Institute for the Science and Humanities, Nihon University, Tokyo, Japan
    • Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY, USA
    • Corresponding Author InformationCorresponding author at: Division of Cancer Genetics, Department of Advanced Medical Research Center, Nihon University School of Medicine, Tokyo 173-8610, Japan. Tel.: +81 3 3972 8337; fax: +81 3 3972 8337.

Received 18 January 2010 ,Revised 3 April 2010 ,Accepted 29 April 2010.

References 

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  11. Ehrich M, Nelson MR, Stanssens P, Zabeau M, Liloglou T, Xinarianos G, et al. Quantitative high-throughput analysis of DNA methylation patterns by base-specific cleavage and mass spectrometry. Proc Natl Acad Sci USA. 2005;102:15785–15790
  12. Wu X, Viveiros MM, Eppig JJ, Bai Y, Fitzpatrick SL, Matzuk MM. Zygote arrest 1 (Zar1) is a novel maternal-effect gene critical for the oocyte-to-embryo transition. Nature Genet. 2003;33:187–191
  13. Wu X, Wang P, Brown CA, Zilinski CA, Matzuk MM. Zygote arrest 1 (Zar1) is an evolutionarily conserved gene expressed in vertebrate ovaries. Biol Reprod. 2003;69:861–867
  14. Sims RJ, Chen CF, Santos-Rosa H, Kouzarides T, Patel SS, Reinberg D. Human but not yeast CHD1 binds directly and selectively to histone H3 methylated at lysine 4 via its tandem chromodomains. J Biol Chem. 2005;280:41789–41792
  15. Wysocka J, Swigut T, Milne TA, Dou Y, Zhang X, Burlingame AL, et al. WDR5 associates with histone H3 methylated at K4 and is essential for H3K4 methylation and vertebrate development. Cell. 2005;121:859–872
  16. Ringrose L, Ehret H, Paro R. Distinct contributions of histone H3 lysine 9 and 27 methylation to locus-specific stability of polycomb complexes. Mol Cell. 2004;16:641–653
  17. Bernstein BE, Mikkelsen TS, Xie X, Kamal M, Huebert DJ, Cuff J, et al. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell. 2006;125:315–326

PII: S0923-1811(10)00158-1

doi: 10.1016/j.jdermsci.2010.04.016

Journal of Dermatological Science
Volume 59, Issue 2 , Pages 98-106 , August 2010

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