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Journal of Dermatological Science
Volume 59, Issue 1
, Pages 1-6
, July 2010
Myeloid derived suppressor cells and their role in tolerance induction in cancer
References
- . Cancer immunology. N Engl J Med. 2008;358:2704–2715
- . Cancer immunotherapy: moving beyond current vaccines. Nat Med. 2004;10:909–915
- . Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol. 2009;9:162–174
- . Altered macrophage differentiation and immune dysfunction in tumor development. J Clin Invest. 2007;117:1155–1166
- . Myeloid derived suppressor cells: linking inflammation and cancer. J Immunol. 2009;182:4499–4506
- Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulation with distinct T cell-suppressive activity. Blood. 2008;111:4233–4244
- Tumor induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells. J Clin Invest. 2006;116:2777–2790
- Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell energy in tumor-bearing host. Cancer Res. 2006;66:1123–1131
- . Subsets of myeloid derived suppressor cells in tumor-bearing mice. J Immunol. 2008;181:5791–5802
- . Mononuclear myeloid-derived “suppressor” cells express RAE-1 and activate natural killer cells. Blood. 2008;112:4080–4089
- . Regulation of triggering receptor expressed on myeloid cell 1 expression on mouse inflammatory monocytes. Immunology. 2009;128:185–195
- Arginase-producing myeloid derived suppressor cells in renal cell carcinoma patients: a mechanism of tumor evasion. Cancer Res. 2005;65:3044–3048
- Reversal of myeloid cell-mediated immunosuppression in patients with metastatic renal cell carcinoma. Clin Cancer Res. 2008;14:8270–8278
- IL4Ralpha+ myeloid-derived suppressor cell expansion in cancer patients. J Immunol. 2009;182:6562–6568
- Arginase 1-producing myeloid derived suppressor cells in renal cell carcinoma are a subpopulation of activated granulocytes. Cancer Res. 2009;69:1553–1560
- CD11b+/Gr-1+ immature myeloid cells mediate suppression of T cells in mice bearing tumors of IL-1β-secreting cells. J Immunol. 2005;175:8200–8208
- . Inflammation induces myeloid-derived suppressor cells that facilitate tumor progression. J Immunol. 2006;176:284–290
- . Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression. Cancer Res. 2007;67:10019–10026
- Arginase 1 in myeloid suppressor cells is induced by COX-2 in lung carcinoma. J Exp Med. 2005;202:931–939
- . Prostaglandin E2 promotes tumor progression by inducing myeloid derived suppressor cells. Cancer Res. 2007;67:4507–4513
- Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein. J Exp Med. 2008;205:2235–2249
- . Proinflammatory S100 proteins regulate the accumulation of myeloid-derived suppressor cells. J Immunol. 2008;181:4666–4675
- Modulation of the antitumor immune response by complement. Nat Immunol. 2008;9:1225–1235
- . Myeloid cell expansion elicited by the progression of spontaneous mammary carcinomas in c-erbB-2 transgenic BALB/c mice suppresses immune reactivity. Blood. 2003;102:2138–2145
- Vascular endothelial growth factor inhibits the development of dendritic cells and dramatically affect the differentiation of multiple hematopoietic linages in vivo. Blood. 1998;92:4150–4166
- Expansion of myeloid immune suppressive Gr1+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis. Cancer Cell. 2004;6:409–421
- Abrogation of TGFβ singaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis. Cancer Cell. 2008;13:23–35
- . Amino-biphosphonate-mediated MMP-9 inhibition breaks the tumor-bone marrow axis responsible for myeloid derived suppressor cell expansion and macrophage infiltration in tumor stroma. Cancer Res. 2007;67:11438–11446
- Chemokine-mediated rapid turnover of myeloid-derived suppressor cells in tumor-bearing mice. Blood. 2008;111:5457–5466
- Reversion of immunotolerance in advanced malignancy: modulation of myeloid-derived suppressor cell development by blockade of stem cell factor function. Blood. 2008;111:219–228
- . Urokinase-mediated recruitment of myeloid-derived suppressor cells and their suppressive mechanisms are blocked by MUC/sec. Blood. 2009;113:4729–4739
- . Myeloid-derived suppressor cells down-regulate l-selectin expression on CD4+ and CD8+ T cells. J Immunol. 2009;183:937–944
- Mechanism regulating reactive oxygen species in tumor-induced myeloid derived suppressor cells. J Immunol. 2009;182:5693–5701
- . STAT1 signaling regulates tuomr-associated macrophage-mediated T cell deletion. J Immunol. 2005;174:4880–4891
- . Cutting edge: Stat6-dependent substrate depletion regulate nitric oxide production. J Immunol. 2001;166:2173–2177
- Transforming growth factor-β production and myeloid cells are an effector mechanism through which CD1d-restricted T cell block cytotoxic T lympocyte-mediated tumor immunosurveillance: abrogation prevents tumor recurrence. J Exp Med. 2003;198:1741–1752
- . l-arginine metabolism in myeloid cell controls T-lymphocyte functions. Trend Immunol. 2003;24:302–306
- . Regulation of T cell receptor CD3ζ chain expression by l-arginine. J Biol Chem. 2002;277:21123–21129
- . l-arginine availability reglates T-lymphocyte cell-cycle progression. Blood. 2007;109:1568–1573
- . Nitric oxide inhibits INF gamma-induced increases in CIITA mRNA abundance and activation of CIITA dependent genes—class II MHC, Il and H-2
M. Class II trans activator. Inflammation. 2000;24:431–445 - . Macrophage-derived nitric oxide regulates T cell activation via reversible disruption of the Jak3/STAT5 signaling pathway. J Immunol. 1998;160:5729–5734
- Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer. Nat Med. 2007;13:828–835
- . Myeloid-derived suppressor cells promote cross-tolerance in B-cell lymphoma by expanding regulatory T cells. Cancer Res. 2008;68:5439–5449
- . CD80 in immune suppression by mouse ovarian carcinoma-associated Gr-1+CD11b+ myeloid cells. Cancer Res. 2006;66:6807–6815
- . Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trend Immunol. 2002;23:549–555
- . Gemcitabine selectively eliminates splenic Gr-1+/CD11b+ myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activity. Clin Cancer Res. 2005;11:6713–6721
- . Increasing circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin-ciclophosphamide chemotherapy. Cancer Immunol Immunother. 2009;58:49–59
- . Mechanism of all-trans retinoic acid effect on tumor-associated myeloid-derived suppressor cells. Cancer Res. 2003;63:4441–4449
- Increased production of immature myeloid cells in cancer patients: a mechanism of immunosuppression in cancer. J Immunol. 2001;166:678–689
PII: S0923-1811(10)00162-3
doi: 10.1016/j.jdermsci.2010.05.001
© 2010 Japanese Society for Investigative Dermatology. Published by Elsevier Inc. All rights reserved.
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Journal of Dermatological Science
Volume 59, Issue 1
, Pages 1-6
, July 2010
