Journal of Dermatological Science
Volume 60, Issue 1 , Pages 8-20 , October 2010

Induced Sézary syndrome PBMCs poorly express immune response genes up-regulated in stimulated memory T cells

  • Benjamin F. Chong

      Affiliations

    • Department of Dermatology, Henry Ford Hospital, Detroit, MI, United States
    • Department of Dermatology, University of Texas Southwestern, Dallas, TX, United States
  • ,
  • Patrick Dantzer

      Affiliations

    • Department of Dermatology, Henry Ford Hospital, Detroit, MI, United States
  • ,
  • Thomas Germeroth

      Affiliations

    • Department of Dermatology, Henry Ford Hospital, Detroit, MI, United States
    • Division of Dermatology, The Ohio State University Medical Center, Columbus, OH, United States
  • ,
  • Mikehl Hafner

      Affiliations

    • Department of Dermatology, Henry Ford Hospital, Detroit, MI, United States
  • ,
  • Adam J. Wilson

      Affiliations

    • Department of Dermatology, Henry Ford Hospital, Detroit, MI, United States
  • ,
  • Guanghua Xiao

      Affiliations

    • Department of Clinical Sciences, University of Texas Southwestern, Dallas, TX, United States
  • ,
  • Henry K. Wong

      Affiliations

    • Department of Dermatology, Henry Ford Hospital, Detroit, MI, United States
    • Division of Dermatology, The Ohio State University Medical Center, Columbus, OH, United States
    • Corresponding Author InformationCorresponding author at: The Ohio State University Medical Center, 2012 Kenny Road, Rm 227, Columbus, OH 43221, United States. Tel.: +1 614 293 4464; fax: +1 614 293 8090.

Received 20 April 2010 ,Revised 13 July 2010 ,Accepted 14 July 2010.

References 

  1. Luqman M, Bottomly K. Activation requirements for CD4+ T cells differing in CD45R expression. J Immunol. 1992;149:2300–2306
  2. Tanchot C, Lemonnier FA, Perarnau B, Freitas AA, Rocha B. Differential requirements for survival and proliferation of CD8 naive or memory T cells. Science. 1997;276:2057–2062
  3. London CA, Lodge MP, Abbas AK. Functional responses and costimulator dependence of memory CD4+ T cells. J Immunol. 2000;164:265–272
  4. Croft M, Bradley LM, Swain SL. Naive versus memory CD4 T cell response to antigen. Memory cells are less dependent on accessory cell costimulation and can respond to many antigen-presenting cell types including resting B cells. J Immunol. 1994;152:2675–2685
  5. Van de Velde H, Lorre K, Bakkus M, Thielemans K, Ceuppens JL, de Boer M. CD45RO+ memory T cells but not CD45RA+ naive T cells can be efficiently activated by remote co-stimulation with B7. Int Immunol. 1993;5:1483–1487
  6. Croft M. Activation of naive, memory and effector T cells. Curr Opin Immunol. 1994;6:431–437
  7. Ehlers S, Smith KA. Differentiation of T cell lymphokine gene expression: the in vitro acquisition of T cell memory. J Exp Med. 1991;173:25–36
  8. Kristensson K, Borrebaeck CA, Carlsson R. Human CD4+ T cells expressing CD45RA acquire the lymphokine gene expression of CD45RO+ T-helper cells after activation in vitro. Immunology. 1992;76:103–109
  9. Armitage RJ, Macduff BM, Ziegler SF, Grabstein KH. Multiple cytokine secretion by IL-7-stimulated human T cells. Cytokine. 1992;4:461–469
  10. Kedl RM, Mescher MF. Qualitative differences between naive and memory T cells make a major contribution to the more rapid and efficient memory CD8+ T cell response. J Immunol. 1998;161:674–683
  11. Cho BK, Wang C, Sugawa S, Eisen HN, Chen J. Functional differences between memory and naive CD8 T cells. Proc Natl Acad Sci USA. 1999;96:2976–2981
  12. Kuhn A, Sontheimer RD. Cutaneous lupus erythematosus: molecular and cellular basis of clinical findings. Curr Dir Autoimmun. 2008;10:119–140
  13. Krathen MS, Fiorentino D, Werth VP. Dermatomyositis. Curr Dir Autoimmun. 2008;10:313–332
  14. Nestle FO, Psoriasis . Curr Dir Autoimmun. 2008;10:65–75
  15. Reinhold U, Abken H, Kukel S, Moll M, Muller R, Oltermann I, et al. CD7- T cells represent a subset of normal human blood lymphocytes. J Immunol. 1993;150:2081–2089
  16. Reinhold U, Abken H. CD4+ CD7- T cells: a separate subpopulation of memory T cells?. J Clin Immunol. 1997;17:265–271
  17. Chong BF, Wilson AJ, Gibson HM, Hafner MS, Luo Y, Hedgcock CJ, et al. Immune function abnormalities in peripheral blood mononuclear cell cytokine expression differentiates stages of cutaneous T-cell lymphoma/mycosis fungoides. Clin Cancer Res. 2008;14:646–653
  18. Schena M, Shalon D, Davis RW, Brown PO. Quantitative monitoring of gene expression patterns with a complementary DNA microarray. Science. 1995;270:467–470
  19. Kim YH, Willemze R, Pimpinelli N, Whittaker S, Olsen EA, Ranki A, et al. TNM classification system for primary cutaneous lymphomas other than mycosis fungoides and Sezary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the cutaneous lymphoma task force of the European Organization of Research and Treatment of Cancer (EORTC). Blood. 2007;110:479–484
  20. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods. 2001;25:402–408
  21. Wong HK, Kammer GM, Dennis G, Tsokos GC. Abnormal NF-kappa B activity in T lymphocytes from patients with systemic lupus erythematosus is associated with decreased p65-RelA protein expression. J Immunol. 1999;163:1682–1689
  22. Hosack DA, Dennis G, Sherman BT, Lane HC, Lempicki RA. Identifying biological themes within lists of genes with EASE. Genome Biol. 2003;4:R70
  23. Liao F, Rabin RL, Smith CS, Sharma G, Nutman TB, Farber JM. CC-chemokine receptor 6 is expressed on diverse memory subsets of T cells and determines responsiveness to macrophage inflammatory protein 3 alpha. J Immunol. 1999;162:186–194
  24. Liu K, Li Y, Prabhu V, Young L, Becker KG, Munson PJ, et al. Augmentation in expression of activation-induced genes differentiates memory from naive CD4+ T cells and is a molecular mechanism for enhanced cellular response of memory CD4+ T cells. J Immunol. 2001;166:7335–7344
  25. Shin HC, Benbernou N, Esnault S, Guenounou M. Expression of IL-17 in human memory CD45RO+ T lymphocytes and its regulation by protein kinase A pathway. Cytokine. 1999;11:257–266
  26. Asao H. Analysis of gammac-dependent cytokines-mediated immunoregulation. Rinsho Byori. 2007;55:51–58
  27. Brinkmann V, Kristofic C. TCR-stimulated naive human CD4+ 45RO-T cells develop into effector cells that secrete IL-13, IL-5, and IFN-gamma, but no IL-4, and help efficient IgE production by B cells. J Immunol. 1995;154:3078–3087
  28. Jones D, O’Hara C, Kraus MD, Perez-Atayde AR, Shahsafaei A, Wu L, et al. Expression pattern of T-cell-associated chemokine receptors and their chemokines correlates with specific subtypes of T-cell non-Hodgkin lymphoma. Blood. 2000;96:685–690
  29. Chen Z, Tato CM, Muul L, Laurence A, O'Shea JJ. Distinct regulation of interleukin-17 in human T helper lymphocytes. Arthritis Rheum. 2007;56:2936–2946
  30. Colantonio L, Recalde H, Sinigaglia F, D’Ambrosio D. Modulation of chemokine receptor expression and chemotactic responsiveness during differentiation of human naive T cells into Th1 or Th2 cells. Eur J Immunol. 2002;32:1264–1273
  31. Vowels BR, Cassin M, Vonderheid EC, Rook AH. Aberrant cytokine production by Sezary syndrome patients: cytokine secretion pattern resembles murine Th2 cells. J Invest Dermatol. 1992;99:90–94
  32. Saed G, Fivenson DP, Naidu Y, Nickoloff BJ. Mycosis fungoides exhibits a Th1-type cell-mediated cytokine profile whereas Sezary syndrome expresses a Th2-type profile. J Invest Dermatol. 1994;103:29–33
  33. Rook AH, Kubin M, Cassin M, Vonderheid EC, Vowels BR, Wolfe JT, et al. IL-12 reverses cytokine and immune abnormalities in Sezary syndrome. J Immunol. 1995;154:1491–1498
  34. Krejsgaard T, Gjerdrum LM, Ralfkiaer E, Lauenborg B, Eriksen KW, Mathiesen AM, et al. Malignant Tregs express low molecular splice forms of FOXP3 in Sezary syndrome. Leukemia. 2008;22:2230–2239
  35. Heid JB, Schmidt A, Oberle N, Goerdt S, Krammer PH, Suri-Payer E, et al. FOXP3+ CD25- tumor cells with regulatory function in Sezary syndrome. J Invest Dermatol. 2009;129:2875–2885
  36. Campbell JJ, Hedrick J, Zlotnik A, Siani MA, Thompson DA, Butcher EC. Chemokines and the arrest of lymphocytes rolling under flow conditions. Science. 1998;279:381–384
  37. Fitzhugh DJ, Naik S, Caughman SW, Hwang ST. Cutting edge: C-C chemokine receptor 6 is essential for arrest of a subset of memory T cells on activated dermal microvascular endothelial cells under physiologic flow conditions in vitro. J Immunol. 2000;165:6677–6681
  38. Homey B, Dieu-Nosjean MC, Wiesenborn A, Massacrier C, Pin JJ, Oldham E, et al. Up-regulation of macrophage inflammatory protein-3 alpha/CCL20 and CC chemokine receptor 6 in psoriasis. J Immunol. 2000;164:6621–6632
  39. Takayanagi H. Mechanistic insight into osteoclast differentiation in osteoimmunology. J Mol Med (Berlin, Germany). 2005;83:170–179
  40. Darnay BG, Haridas V, Ni J, Moore PA, Aggarwal BB. Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase. J Biol Chem. 1998;273:20551–20555
  41. Franchimont N, Reenaers C, Lambert C, Belaiche J, Bours V, Malaise M, et al. Increased expression of receptor activator of NF-kappaB ligand (RANKL), its receptor RANK and its decoy receptor osteoprotegerin in the colon of Crohn's disease patients. Clin Exp Immunol. 2004;138:491–498
  42. Lerebours F, Vacher S, Andrieu C, Espie M, Marty M, Lidereau R, et al. NF-kappa B genes have a major role in inflammatory breast cancer. BMC Cancer. 2008;8:41
  43. Booken N, Gratchev A, Utikal J, Weiss C, Yu X, Qadoumi M, et al. Sezary syndrome is a unique cutaneous T-cell lymphoma as identified by an expanded gene signature including diagnostic marker molecules CDO1 and DNM3. Leukemia. 2008;22:393–399

 Grant support: Fund for Henry Ford Hospital, the Clarence Livingood Fund, the Dermatology Foundation Clinical Career Development Award (HKW), La-Roche Posay North American Foundation (BFC) and NIH NIAMS K08-47818 and R21-52877 (HKW).

PII: S0923-1811(10)00229-X

doi: 10.1016/j.jdermsci.2010.07.007

Journal of Dermatological Science
Volume 60, Issue 1 , Pages 8-20 , October 2010