Journal of Dermatological Science
Volume 60, Issue 1 , Pages 40-42 , October 2010

Abnormal DNA methylation in skin lesions and PBMCs of patients with psoriasis vulgaris

  • Peng Zhang

      Affiliations

    • These authors contributed equally to this work.
    • ,
  • Yuwen Su

      Affiliations

    • These authors contributed equally to this work.
    • ,
  • Huan Chen
    • ,
  • Ming Zhao
    • ,
  • Qianjin Lu

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +86 13787097676; fax: +86 731 5533525.

Received 30 March 2010

References 

  1. Li Y, Sawalha AH, Lu Q. Aberrant DNA methylation in skin diseases. J Dermatol Sci. 2009;54:143–149
  2. Gündüz K, Demireli P, Vatansever S, Inanir I. Examination of bcl-2 and p53 expressions and apoptotic index by TUNEL method in psoriasis. J Cutan Pathol. 2006;33:788–792
  3. Luo Y, Li Y, Su Y, Yin H, Hu N, Wang S, et al. Abnormal DNA methylation in T cells from patients with subacute cutaneous lupus erythematosus. Br J Dermatol. 2008;159:827–833
  4. Rountree MR, Bachman KE, Herman JG, Baylin SB. DNA methylation, chromatin inheritance, and cancer. Oncogene. 2001;20:3156–3165
  5. Okubo Y, Koga M. Peripheral blood monocytes in psoriatic patients overproduce cytokines. J Dermatol Sci. 1998;17:223–232
  6. Brody I. Dermal and epidermal involvement in the evolution of acute eruptive guttate psoriasis vulgaris. J Invest Dermatol. 1984;82:465–470
  7. Hendrich B, Bird A. Identification and characterization of a family of mammalian methyl-CpG binding proteins. Mol Cell Biol. 1998;18:6538–6547
  8. Marshall CJ. Tumor suppressor genes. Cell. 1991;64:313–326
  9. Chen M, Chen ZQ, Cui PG, Yao X, Li YM, Li AS, et al. The methylation pattern of p16INK4a gene promoter in psoriatic epidermis and its clinical significance. Br J Dermatol. 2008;158:987–993
  10. Zhang Y, Xiong Y, Yarbrough WG. ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell. 1998;92:725–734

PII: S0923-1811(10)00233-1

doi: 10.1016/j.jdermsci.2010.07.011

Journal of Dermatological Science
Volume 60, Issue 1 , Pages 40-42 , October 2010

Article Tools

* Image Usage & Resolution