« Previous
Next »
Journal of Dermatological Science
Volume 65, Issue 1
, Pages 12-18
, January 2012
Hypoxia regulates the expression of extracellular matrix associated proteins in equine dermal fibroblasts via HIF1
References
- . Wound repair and regeneration. Nature. 2008;453:314–321
- . Pathophysiology of acute wound healing. Clin Dermatol. 2007;25:9–18
- . Donor-age-related changes in the morphology, growth potential, and collagen biosynthesis in rat fibroblast subpopulations in vitro. Differentiation. 1986;32:165–172
- . Wound healing: an overview. Plast Reconstr Surg. 2006;117:1e-S–32e-S
- . Hypoxia promotes fibrogenesis in human renal fibroblasts. Kidney Int. 2000;58:2351–2366
- . Differences in wound healing between horses and ponies. In: Stashak TS, Theoret CL editor. Equine wound management. Iowa: Wiley-Blackwell; 2008;p. 29–46
- . Profiling the New Zealand thoroughbred racing industry. 2. Conditions interfering with training and racing. N Z Vet J. 2005;53:69–76
- . Keloid or hypertrophic scar: the controversy: review of the literature. Ann Plast Surg. 2005;54:676–680
- . Regional differences in wound oxygenation during normal healing in an equine model of cutaneous fibroproliferative disorder. Wound Repair Regen. 2011;19:89–97
- . Comparative study on microvascular occlusion and apoptosis in body and limb wounds in the horse. Wound Repair Regen. 2005;13:520–529
- Mechanisms of hypoxic regulation of plasminogen activator inhibitor-1 gene expression in keloid fibroblasts. J Invest Dermatol. 2003;121:1005–1012
- . Oxygen in wound healing – more than a nutrient. World J Surg. 2004;28:294–300
- . Hypoxia upregulates the synthesis of TGF-beta 1 by human dermal fibroblasts. J Invest Dermatol. 1991;97:634–637
- Low oxygen tension increases mRNA levels of alpha 1 (I) procollagen in human dermal fibroblasts. J Cell Physiol. 1993;157:408–412
- . Effect of hypoxia on stimulatory effect of TGF-beta 1 on MMP-2 and MMP-9 activities in mouse fibroblasts. J Soc Gynecol Investig. 2000;7:348–354
- . Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature. 2006;441:437–443
- Physiologic responses to hypoxia and implications for hypoxia-inducible factors in the pathogenesis of rheumatoid arthritis. Arthritis Rheum. 2004;50:10–23
- . Biology of HIF-1alpha. Cell Death Differ. 2008;15:621–627
- . Hypoxia-inducible factor (HIF-1)alpha: its protein stability and biological functions. Exp Mol Med. 2004;36:1–12
- Physiologically low oxygen concentrations in fetal skin regulate hypoxia-inducible factor 1 and transforming growth factor-beta3. Faseb J. 2002;16:411–413
- . Sustained expression of Hif-1alpha in the diabetic environment promotes angiogenesis and cutaneous wound repair. Wound Repair Regen. 2007;15:636–645
- . Signaling by hypoxia-inducible factors is critical for ovulation in mice. Endocrinology. 2009;150:3392–3400
- . Constitutive expression of hypoxia-inducible factor-1 alpha in keratinocytes during the repair of skin wounds in horses. Wound Repair Regen. 2011;19:250–259
- . A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 2001;29:e45
- Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity. Cancer Res. 2005;65:9047–9055
- Celeste CJ, Deschene K, Riley CB, Theoret CL. Kinetics of blood flow and anatomical-site differences in tissue perfusion during wound healing in an equine model of cutaneous fibroproliferative disorder. Vet Surg; under review.
- . Differential effects of oxygen on human dermal fibroblasts: acute versus chronic hypoxia. Wound Repair Regen. 1996;4:211–218
- . Apoptosis and proliferation of human peritoneal fibroblasts in response to hypoxia. Fertil Steril. 2002;78:137–143
- p53 and apoptosis alterations in keloids and keloid fibroblasts. Wound Repair Regen. 1998;6:28–37
- . The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis. J Clin Pathol. 2004;57:1009–1014
- . Microbiology of equine wounds and evidence of bacterial biofilms. Vet Microbiol. 2011;150:152–159
- . Chronic equine wounds: what is the role of infection and biofilms?. Wounds. 2010;22:138–145
- . Differences in second-intention wound healing between horses and ponies: macroscopic aspects. Equine Vet J. 1999;31:53–60
- . Basic wound management. In: Knottenbelt DC editors. Handbook of equine wound management. London: Saunders; 2003;p. 54–73
- . Hypoxia impairs skin myofibroblast differentiation and function. J Invest Dermatol. 2010;130:2818–2827
- Hypoxia-induced increase in the production of extracellular matrix proteins in systemic sclerosis. Arthritis Rheum. 2007;56:4203–4215
- . Hypoxia induces expression of connective tissue growth factor in scleroderma skin fibroblasts. Clin Exp Immunol. 2006;146:362–370
- . Crosstalk of hypoxia-mediated signaling pathways in upregulating plasminogen activator inhibitor-1 expression in keloid fibroblasts. J Cell Physiol. 2004;199:89–97
- . Mechanisms of fibrogenesis. Exp Biol Med (Maywood). 2008;233:109–122
- . Expression of transforming growth factor beta(1), beta(3), and basic fibroblast growth factor in full-thickness skin wounds of equine limbs and thorax. Vet Surg. 2001;30:269–277
- . Transforming growth factor-beta levels during second-intention healing are related to the different course of wound contraction in horses and ponies. Wound Repair Regen. 2002;10:188–194
- . Dual effect of echinomycin on hypoxia-inducible factor-1 activity under normoxic and hypoxic conditions. Febs J. 2007;274:5533–5542
- . Hypoxia induced by CoCl2 influencing the expression and the activity of matrix metalloproteinase-2 in rat hepatic stellate cells. Zhonghua Gan Zang Bing Za Zhi. 2007;15:654–657
- . Hypoxia and a hypoxia mimetic up-regulate matrix metalloproteinase 2 and 9 in equine laminar keratinocytes. Vet J. 2011;
- Hypoxia down-regulates secretion of MMP-2, MMP-9 in porcine pulmonary artery endothelial and smooth muscle cells and the role of HIF-1. J Huazhong Univ Sci Technolog Med Sci. 2005;25(407):382–384
☆ Research was funded by the Natural Sciences and Engineering Research Council (NSERC) of Canada.
PII: S0923-1811(11)00281-7
doi: 10.1016/j.jdermsci.2011.09.006
© 2011 Japanese Society for Investigative Dermatology. Published by Elsevier Inc. All rights reserved.
« Previous
Next »
Journal of Dermatological Science
Volume 65, Issue 1
, Pages 12-18
, January 2012
