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Migration of human melanocytes into keratinocyte monolayers in vitro
06 February 2012
Dheshnie Keswell, Lester M. Davids, Susan H. Kidson
The repigmentation of adult skin after wound healing, or loss of melanocytes (e.g. vitiligo), poses a particular and unique challenge to the invading population of melanocytes. The melanocytes, or the...
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Mcl-1 determines the imiquimod-induced apoptosis but not imiquimod-induced autophagy in skin cancer cells
06 February 2012
Shi-Wei Huang, Chia-Che Chang, Chi-Chen Lin, Jaw-Ji Tsai, Yi-Ju Chen, Chun-Ying Wu, Kuang-Ting Liu, Jeng-Jer Shieh
Abstract: Background: Imiquimod had been shown to induce apoptosis and autophagy in several skin cancer cells, especially basal cell carcinoma (BCC) cells. Objective: We evaluate the molecular mechani...
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Spectroscopic evidence of abnormal structure of psoriasis vulgaris stratum corneum
06 February 2012
Kouichi Nakagawa, Satoko Minakawa, Daisuke Sawamura
EPR (electron paramagnetic resonance) is useful for elucidating structural aspects of stratum corneum (SC) . Non-invasive spectroscopic characterization of the outermost layer of the SC is an importan...
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Inflammatory response of human keratinocytes triggered by Sporothrix schenckii via toll-like receptor 2 and 4
06 February 2012
Min Li, Qing Chen, Jun Sun, Yongnian Shen, Weida Liu
Sporotrichosis is the most common cutaneous and subcutaneous mycosis caused by the dimorphic fungus Sporothrix schenckii of which conidia and/or hyphae could convert into yeast form at the site of inf...
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TNF-α increases lipogenesis via JNK and PI3K/Akt pathways in SZ95 human sebocytes
03 February 2012
Jeong June Choi, Min Young Park, Hwa Jin Lee, Do-young Yoon, Yoongho Lim, Jin Won Hyun, Christos C. Zouboulis, Mirim Jin
Abstract: Background: Tumor necrosis factor-alpha (TNF-α) is an important pathophysiologic factor involved in the development of acne. However, its role is unclear. Objective: To explore the lipogenic...
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