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Regular paper| Volume 2, ISSUE 5, P341-345, September 1991

Cutaneous responses to topical methyl nicotinate in human forearm and vulvar skin

  • Peter Elsner
    Affiliations
    Department of Dermatology, School of Medicine, University of California, San Francisco, California, U.S.A.

    Department of Dermatology, School of Medicine, University of Würzburg, F.R.G.
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  • Howard I. Maibach
    Correspondence
    Correspondence to: H.I. Maibach, Department of Dermatology, University of California School of Medicine, Box 0989, Surge 110, San Francisco, CA 94143-0989, U.S.A.
    Affiliations
    Department of Dermatology, School of Medicine, University of California, San Francisco, California, U.S.A.
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DOI:https://doi.org/10.1016/0923-1811(91)90027-U
Cutaneous responses to topical methyl nicotinate in human forearm and vulvar skin
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      Abstract

      In order to identify and define differences in percutaneous absorption and microcirculatory sensitivity between forearm and vulvar skin we studied the response of human forearm and vulvar (labium majus) skin to topical methyl nicotinate (MN) in 11 healthy premenopausal volunteers. MN-induced erythema was assessed by laser Doppler velocimetry (LDV). The following parameters were compared: 1) basal cutaneous blood flow, 2) the time to peak response, 3) the magnitude of LDV peak response, 4) the area under the LDV resonse-time curve and 5) the decay time to 75% of peak response.
      Basal cutaneous blood flow at the vulva was higher than at the forearm (P < 0.05); the magnitude of peak response was lower at the vulva than at the forearm (P < 0.01); the area under the curve was lower at the vulva than at the forearm (P < 0.001); the decay time to 75% of peak response was shorter at the vulva than at the forearm (P < 0.001). The time to peak response showed no significant differences between sites.
      The results indicate that the MN-induced vasodilatation is less intense and lasts shorter in vulvar compared to forearm skin.

      Keywords

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      Article info

      Publication history

      Accepted: March 30, 1991
      Received: June 11, 1990

      Identification

      DOI: https://doi.org/10.1016/0923-1811(91)90027-U

      Copyright

      © 1991 Published by Elsevier Inc.

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