This paper is only available as a PDF. To read, Please Download here.
Abstract
In order to identify and define differences in percutaneous absorption and microcirculatory
sensitivity between forearm and vulvar skin we studied the response of human forearm
and vulvar (labium majus) skin to topical methyl nicotinate (MN) in 11 healthy premenopausal
volunteers. MN-induced erythema was assessed by laser Doppler velocimetry (LDV). The
following parameters were compared: 1) basal cutaneous blood flow, 2) the time to
peak response, 3) the magnitude of LDV peak response, 4) the area under the LDV resonse-time
curve and 5) the decay time to 75% of peak response.
Basal cutaneous blood flow at the vulva was higher than at the forearm (P < 0.05); the magnitude of peak response was lower at the vulva than at the forearm
(P < 0.01); the area under the curve was lower at the vulva than at the forearm (P < 0.001); the decay time to 75% of peak response was shorter at the vulva than at
the forearm (P < 0.001). The time to peak response showed no significant differences between sites.
The results indicate that the MN-induced vasodilatation is less intense and lasts
shorter in vulvar compared to forearm skin.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of Dermatological ScienceAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Physiologie der Haut der Vulva: neue Aspekte.Hautarzt. 1989; 40: 411-417
- Human percutaneous penetration of hydrocortisone: the vulva.Arch Dermatol Res. 1980; 267: 313-316
Oriba HA, Bucks DAW, Maibach HI: Percutaneous absorption of hydrocortisone and testosterone at vulva and forearm: effect of age and site. (submitted for publication).
- Mass balance and dose accountability in percutaneous absorption studies: Development of a non-occlusive application system.Pharm Res. 1988; 5: 313-315
- Evaluation of a laser Doppler flowmeter for measurement of tissue blood flow.IEEE Trans Biomed Eng. 1980; 27: 597-604
- A new instrument for continuous measurement of tissue blood flow by light beating spectroscopy.IEEE Trans Biomed Eng. 1980; 27: 12-19
- Laser Doppler measurement of cutaneous blood flow.J Invest Dermatol. 1977; 69: 306-309
- Are there age and racial differences to methyl nicotinate-induced vasodilation in human skin?.J Am Acad Dermatol. 1985; 12: 1001-1006
- Pharmacodynamic measurements of methyl nicotinate percutaneous absorption.Pharm Res. 1984; 1: 76-81
- Noninvasive assessment of local nicotinate pharmacodynamics by photoplethysmography.J Invest Dermatol. 1983; 80: 499-503
- Noninvasive assessments of the percutaneous absorption of methyl nicotinate in humans.J Pharm Sci. 1983; 72: 1077-1079
- Percutaneous penetration of nicotinates: in vivo and in vitro measurements.J Pharm Sci. 1986; 75: 968-972
- The rate of absorption and duration of action of four different solutions of methyl nicotinate.Br J Dermatol. 1969; 81: 202-206
- Determination of vehicle effects on percutaneous absorption by laser Doppler velocimetry.Arch Dermatol Res. 1986; 278: 500-502
- Surfactant effects in topical drug availability.Int J Pharmaceut. 1988; 41: 189-195
- Pharmacodynamic measurement of percutaneous penetration enhancement in vivo.J Pharmaceut Sci. 1986; 75: 374-377
- Methodology to measure the transient effect of occlusion on skin penetration and stratum corneum hydration in vivo.Br J Dermatol. 1988; 199: 307-312
- Cutaneous responses to topical methyl nicotinate in black, oriental and caucasian subjects.Arch Derm Res. 1989; 281: 95-98
- Normal vulvar skin: a model for specialized skin.in: Maibach HI Lowe N Models in Dermatology, 1. Karger, Basel1985: 83-88
- Sodium lauryl sulfate-induced irritant contact dermatitis in vulvar and forearm skin of pre- and postmenopausal women.J Am Acad Dermatol. 1990; 23: 648-652
Article info
Publication history
Accepted:
March 30,
1991
Received:
June 11,
1990
Identification
Copyright
© 1991 Published by Elsevier Inc.
