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Abstract
Classical assays of topical corticosteroid potency based on the induction of vasoconstriction
are unsatisfactory for a number of reasons. These include the doubtful relevance of
vasoconstriction to immune inflammation, and more importantly, the inability to compare
non-steroidal agents with corticosteroids. Here we describe a simple assay in which
the inhibitory effect of agents upon delayed type hypersensitivity response to dinitrochlorobenzene
can be quantified by measurements of reaction as skinfold thickness with Harpenden
callipers. Using this system we have confirmed the greater potency of clobetasol propionate
(Dermovate) compared with betamethasone valerate (Betnovate), but the evidence for
an inhibitory effect of topical cyclosporin (10% cream) compared with base on this
response is less convincing.
Keywords
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References
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Article info
Publication history
Accepted:
March 9,
1992
Received:
November 25,
1991
Identification
Copyright
© 1992 Published by Elsevier Inc.
