Research Article| Volume 4, ISSUE 1, P38-41, July 1992

Clinical and laboratory presentation of lichen planus patients with chronic liver disease

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      A recent case-control study on 577 lichen planus (LP) patients and 1008 controls confirmed that LP patients may significantly associate with a chronic liver disease (CLD) which is independent from drug or alcohol intake and has some connection with hepatitis B virus (HBV) infection. The study, however, failed to define the nature of CLD. This has been investigated through the clinical and laboratory features of 50 patients with LP and impaired liver function tests. Overall, the laboratory signs of cell necrosis prevailed over those of cholestasis and a good relationship with the HBV and HCV infections was found. Ninety percent of patients with LP and CLD had antibodies to one or another of the major viruses involved in infectious hepatitis. No patient had anti-liver kidney microsomal antibodies type 1. Liver biopsies were done in 12 cases and mostly revealed a chronic active hepatitis evolving into cirrhosis. No evident cases of primary biliary cirrhosis were found. It appears that LP associated CLD is post-viral in nature.


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        • Rebora A
        • Patri PL
        • Rampini E
        • Crovato F
        • Ciravegna G
        Erosive lichen planus and cirrhotic hepatitis.
        It Gen Rev Dermatol. 1978; 15: 123-127
        • Rebora A
        Lichen planus and the liver.
        Lancet. 1981; i: 805
        • Graham Brown RA
        • Sarkany I
        • Sherlock S
        Lichen planus and primary biliary cirrhosis.
        Br J Dermatol. 1982; 106: 699-703
        • Rongioletti F
        • Rebora A
        Lichen planus and chronic active hepatitis. A retrospective survey.
        Acta Derm Venereol. 1984; 64: 52-56
        • Korkij W
        • Chuang T-Y
        • Soltani K
        Liver abnormalities in patients with lichen planus. A retrospective case-control study.
        J Am Acad. Dermatol. 1984; 11: 609-615
        • Gruppo Italiano Studi Epidemiologici in Dermatologia (GISED)
        Lichen planus and liver disease: a multicentre case-control study.
        Br Med J. 1990; 300: 227-230
        • Olmo JA del
        • Bagan JV
        • Rodrigo JM
        • et al.
        Oral lichen planus and hepatic cirrhosis.
        Ann Intem Med. 1989; 110: 666
        • Tortel J
        Bilan hépatique systématique dans le lichen plan.
        in: 4th edn. Thèse de Doctorat. Université L. Pasteur, Strasbourg1990
        • Ciaccio M
        • Rebora A
        Lichen planus following HBV vaccination: a coincidence?.
        Br J Dermatol. 1990; 122: 424
        • Virgili A
        • Robert E
        • Rebora A
        Hepatocellular carcinoma and lichen planus.
        Dermatology. 1992; 184: 137-138
        • Kew MC
        • Houghton M
        • Choo QL
        • Kuo G
        Hepatitis C virus antibodies in southern African blacks with hepatocellular carcinoma.
        Lancet. 1990; 335: 873-874
        • Ayoola EA
        Viral hepatitis in Africa.
        in: Zuckerman AJ Viral Hepatitis and Liver Disease. Alan R Liss, Inc, New York1988: 161-169
        • Black MM
        Lichen planus and lichenoid eruptions.
        in: 4th edn. Textbook of Dermatology. Blackwell Sci. Publ, Oxford1986: 1668
        • McFarlane IG
        • Smith HM
        • Johnson PJ
        • Bray GP
        • Vergani D
        • Williams R
        Hepatitis C virus antibodies in chronic active hepatitis: pathogenetic factor or false-positive result?.
        Lancet. 1990; 335: 754-757
        • Lenzi M
        • Ballardini G
        • Fusconi M
        • et al.
        Type 2 autoimmune hepatitis and hepatitis C virus infection.
        Lancet. 1990; 335: 258-259
        • Homberg J-C
        • Abuaf N
        • Bernard O
        • et al.
        Chronic active hepatitis associated with antiliver-kidney microsome antibody type I: a second type of ‘autoimmune’ hepatitis.
        Hepatology. 1987; 7: 1333-1339
        • Sherlock S
        Primary biliary cirrhosis: critical evaluation and treatment policies.
        Scand J Gastroenterol. 1982; : 63-74
        • James O
        • Macklon AF
        • Watson AJ
        Primary biliary cirrhosis — a revised clinical spectrum.
        Lancet. 1981; i: 1278-1280
        • Calandra P
        Lichen ruber planus, morfea, sclerosi sistemica ed epatite cronica attiva.
        G It Dermatol Venereol. 1972; 47: 436-439
        • Reynolds TB
        • Denison EK
        • Frankl HD
        • Lieberman FL
        • Peters RL
        Primary biliary cirrhosis with scleroderma, Raynaud's phenomenon and teleangiectasia. New syndrome.
        Am J Med. 1971; 50: 302-312