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Abstract
Endoglin is a glycoprotein with TGF-β binding capacity and is predominantly expressed
on endothelial cells. In psoriasis, TGF-β has appeared to play a role in the extravasation
of peripheral blood mononuclear cells via the endothelium. In order to find out more
about the role of endoglin in psoriasis, immunohistochemical staining with PN-E2,
a novel anti-endoglin, and of PAL-E, recognizing vascular endothelium, was carried
out in psoriatic involved, psoriatic uninvolved and normal skin. The expression of
the antigens was assessed semi-quantitatively using a five-point scale. In psoriatic
involved skin, a high endoglin expression was found. In psoriatic uninvolved skin,
however, we found that endoglin expression was significantly decreased compared with
normal skin. The relevance of these findings to the pathogenesis of psoriasis is discussed.
Keywords
Abbreviations:
DMEC (dermal microvascular endothelial cells), HEV (high endothelial venules), IL (interleukin), LTB4 (leukotriene B4), mAb (monoclonal antibody), PBMC (peripheral blood mononuclear cells), PMN (polymorphonuclear leukocytes), TGF-β (transforming growth factor beta), TNF (tumor necrosis factor)To read this article in full you will need to make a payment
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Article info
Publication history
Accepted:
January 1,
1995
Received in revised form:
November 25,
1994
Received:
July 4,
1994
Identification
Copyright
© 1995 Published by Elsevier Inc.
