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Influence of genetic polymorphisms on interleukin-10 mRNA expression and psoriasis susceptibility

  • Külli Kingo
    Affiliations
    Department of Dermatology and Venerology, University of Tartu, Tartu, Estonia

    Centre of Molecular and Clinical Medicine, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia
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  • Ranno Rätsep
    Affiliations
    Department of Physiology, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia

    Centre of Molecular and Clinical Medicine, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia

    Institute of Zoology and Hydrobiology, University of Tartu, 46 Vanemuise Street, 51014 Tartu, Estonia
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  • Sulev Kõks
    Correspondence
    Corresponding author. Tel.: +3727 374 335; fax: +3727 374 332.
    Affiliations
    Department of Physiology, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia

    Centre of Molecular and Clinical Medicine, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia
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  • Maire Karelson
    Affiliations
    Department of Dermatology and Venerology, University of Tartu, Tartu, Estonia
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  • Helgi Silm
    Affiliations
    Department of Dermatology and Venerology, University of Tartu, Tartu, Estonia
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  • Eero Vasar
    Affiliations
    Department of Physiology, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia

    Centre of Molecular and Clinical Medicine, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia
    Search for articles by this author
      Psoriasis is a chronic inflammatory skin disease, in which overexpression of inflammatory cytokines has been demonstrated, but several findings suggest that, additionally, anti-inflammatory cytokines and their receptors (IL-1Ra, IL-10) play a critical part in the disease pathogenesis [
      • Asadullah K.
      • Sterry W.
      • et al.
      IL-10 is a key cytokine in psoriasis. Proof of principle by IL-10 therapy – a new therapeutic approach.
      ]. In psoriatic lesions, low cutaneous IL-10 protein expression level and low IL-10 concentration in blister fluid have been observed [
      • Nickoloff B.J.
      • Fivenson D.P.
      • et al.
      Keratinocyte IL-10 expression is upregulated in tape-stripped skin poison ivy dermatitis, and Sezary syndrome, but not in psoriatic plaques.
      ,
      • Mussi A.
      • Bonifati C.
      • Carducci M.
      • et al.
      IL-10 levels are decreased in psoriatic lesional skin as compared to the psoriatic lesional-free and normal skin suction blister fluids.
      ]. Lower IL-10 protein secretion capacities of peripheral blood leukocytes in response to endotoxin in psoriatic patients compared with patients with cutaneous T-cell lymphoma, atopic dermatitis and healthy controls have also been reported, but differences failed to reach statistical significance [
      • Asadullah K.
      • Sterry W.
      • et al.
      IL-10 is a key cytokine in psoriasis. Proof of principle by IL-10 therapy – a new therapeutic approach.
      ].

      Keywords

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