Summary
Background
Although wrinkling is the most obvious sign of aged skin, the detailed pathomechanism
of wrinkle development has not been elucidated.
Objectives
In this study, we investigated the role of elastic fibers in the formation of skin
wrinkles.
Methods
Loss of elastic fibers was measured quantitatively in the facial skins of subjects
representing seven decades, and then compared with wrinkle severities. We also investigated
whether topical retinoic acid treatment to photoaged human skin can restore destroyed
elastic fiber, and the correlation between wrinkle improvement with increase in elastic
fibers in RA-treated facial skin.
Results
We found a significant correlation between decreases in the length, width, number
and total area of oxytalan fibers and wrinkle severity. Furthermore, we found that
topical application of retinoic acid (0.025%) to chronically photodamaged skin regenerated
and restored elastic fibers, and that there was a significant positive correlation
between the amount of newly regenerated elastic fiber and the wrinkle improvement
caused by retinoic acid.
Conclusions
Our results provide an objective insight into the role of elastic fibers in skin wrinkle
formation by providing a quantitative correlation between changes in oxytalan fibers
and the severity of skin wrinkling.
Keywords
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References
- Molecular basis of sun-induced premature skin ageing and retinoid antagonism.Nature. 1996; 379: 335-339
- Ultraviolet modulation of human macrophage metalloelastase in human skin in vivo.J Invest Dermatol. 2002; 119: 507-512
- Photoaging and topical tretinoin: therapy, pathogenesis, and prevention.Arch Dermatol. 1997; 133: 1280-1284
- Topical tretinoin improves photoaged skin. A double-blind vehicle-controlled study.JAMA. 1988; 259: 527-532
- Restoration of collagen formation in photodamaged human skin by tretinoin (retinoic acid).N Engl J Med. 1993; 329: 530-535
- Pathophysiology of premature skin aging induced by ultraviolet light.N Engl J Med. 1997; 337: 1419-1428
- Studies in cutaneous aging. I. The elastic fiber network.J Invest Dermatol. 1982; 78: 434-443
- Ultraviolet radiation increases tropoelastin mRNA expression in the epidermis of human skin in vivo.J Invest Dermatol. 2001; 116: 915-919
- Cutaneous photodamage in Koreans: influence of sex, sun exposure, smoking, and skin color.Arch Dermatol. 2001; 137: 1043-1051
- Microrelief of the skin using a light transmission method.Arch Dermatol Res. 2000; 292: 500-510
- A short-term screening protocol, using fibrillin-1 as a reporter molecule, for photoaging repair agents.J Invest Dermatol. 2001; 116: 672-678
- Extracellular matrix 4: the elastic fiber.Faseb J. 1993; 7: 1208-1218
- Fibrillin-rich microfibrils are reduced in photoaged skin Distribution at the dermal-epidermal junction.J Invest Dermatol. 1999; 112: 782-787
Article info
Publication history
Published online: July 12, 2010
Accepted:
November 12,
2007
Received in revised form:
November 5,
2007
Received:
July 23,
2007
Identification
Copyright
© 2008 Japanese Society for Investigative Dermatology. Published by Elsevier Inc. All rights reserved.
