Advertisement

Further association analysis of chr 6q22-24 suggests a role of IL-20RA polymorphisms in psoriasis

      In our previous studies we obtained evidence that the interleukin-19 (IL19) gene cluster and interleukin-20 receptor alpha (IL20RA) gene may represent susceptibility regions for psoriasis [
      • Kõks S.
      • Kingo K.
      • Rätsep R.
      • Karelson M.
      • Silm H.
      • Vasar E.
      Combined haplotype analysis of the interleukin-19 and -20 genes: relationship to plaque-type psoriasis.
      ,
      • Kõks S.
      • Kingo K.
      • Vabrit K.
      • Rätsep R.
      • Karelson M.
      • Silm H.
      • et al.
      Possible relations between the polymorphisms of the cytokines IL-19, IL-20 and IL-24 and plaque-type psoriasis.
      ,
      • Kingo K.
      • Mossner R.
      • Ratsep R.
      • Raud K.
      • Kruger U.
      • Silm H.
      • et al.
      Association analysis of IL20RA and IL20RB genes in psoriasis.
      ]. The aim of the present study was to scan an additional set of single nucleotide polymorphisms (SNPs) in the chromosomal region 6q22-24, which contains IL20RA, the genes for interleukin-22 receptor alpha 2 (IL22RA2) and interferon-gamma receptor 1 (IFNGR1) for association with psoriasis.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Journal of Dermatological Science
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Kõks S.
        • Kingo K.
        • Rätsep R.
        • Karelson M.
        • Silm H.
        • Vasar E.
        Combined haplotype analysis of the interleukin-19 and -20 genes: relationship to plaque-type psoriasis.
        Genes Immun. 2004; 5: 662-667
        • Kõks S.
        • Kingo K.
        • Vabrit K.
        • Rätsep R.
        • Karelson M.
        • Silm H.
        • et al.
        Possible relations between the polymorphisms of the cytokines IL-19, IL-20 and IL-24 and plaque-type psoriasis.
        Genes Immun. 2005; 6: 407-415
        • Kingo K.
        • Mossner R.
        • Ratsep R.
        • Raud K.
        • Kruger U.
        • Silm H.
        • et al.
        Association analysis of IL20RA and IL20RB genes in psoriasis.
        Genes Immun. 2008; 9: 445-451
        • De la Vega F.M.
        • Lazaruk K.D.
        • Rhodes M.D.
        • Wenz M.H.
        Assessment of two flexible and compatible SNP genotyping platforms: TaqMan SNP Genotyping Assays and the SNPlex Genotyping System.
        Mutat Res. 2005; 573: 111-135
        • Barrett J.C.
        • Fry B.
        • Maller J.
        • Daly M.J.
        Haploview: analysis and visualization of LD and haplotype maps.
        Bioinformatics. 2005; 21: 263-265
        • Chan J.R.
        • Blumenschein W.
        • Murphy E.
        • Diveu C.
        • Wiekowski M.
        • Abbondanzo S.
        • et al.
        IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis.
        J Exp Med. 2006; 203: 2577-2587
        • Stenderup K.
        • Rosada C.
        • Worsaae A.
        • Dagnaes-Hansen F.
        • Steiniche T.
        • Hasselager E.
        • et al.
        Interleukin-20 plays a critical role in maintenance and development of psoriasis in the human xenograft transplantation model.
        Br J Dermatol. 2008;
        • Stenderup K.
        • Rosada C.
        • Worsaae A.
        • Clausen J.T.
        • Norman Dam T.
        Interleukin-20 as a target in psoriasis treatment.
        Ann NY Acad Sci. 2007; 1110: 368-381
        • Sa S.M.
        • Valdez P.A.
        • Wu J.
        • Jung K.
        • Zhong F.
        • Hall L.
        • et al.
        The effects of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis.
        J Immunol. 2007; 178: 2229-2240
        • Wei C.C.
        • Chen W.Y.
        • Wang Y.C.
        • Chen P.J.
        • Lee J.Y.
        • Wong T.W.
        • et al.
        Detection of IL-20 and its receptors on psoriatic skin.
        Clin Immunol. 2005; 117: 65-72