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The CD226 Gly307Ser gene polymorphism is associated with severity of psoriasis

      Psoriasis is a chronic inflammatory T-cell mediated disease of the skin with a complex pathogenesis involving both genetic and environmental factors [
      • Campalani E.
      • Barker J.N.W.N.
      The clinical genetics of psoriasis.
      ]. Several regions in the genome including the major histocompatibility complex (MHC) [
      • Tiilikainen A.
      • Lassus A.
      • Karvonen J.
      • Vartiainen P.
      • Julin M.
      Psoriasis and HLA-Cw6.
      ,
      • Trembath R.C.
      • Clough R.L.
      • Rosbotham J.L.
      • Jones A.B.
      • Camp R.D.R.
      • Frodsham A.
      • et al.
      Identification of a major susceptibility locus on chromosome 6p and evidence for further disease loci revealed by a two stage genome-wide search in psoriasis.
      ] have been reported to confer susceptibility to psoriasis risk; however, the genetic background of psoriasis is yet to be established. The Cluster of Differentiation 226 (CD226) molecule by interacting with its ligands, mediates a variety of cellular responses including innate and adaptive immunity [
      • Shibuya A.
      • Campbell D.
      • Hannum C.
      • Yssel H.
      • Franz-Bacon K.
      • McClanahan T.
      • et al.
      DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes.
      ,
      • Bottino C.
      • Castriconi R.
      • Pende D.
      • Rivera P.
      • Nanni M.
      • Carnemolla B.
      • et al.
      Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule.
      ]. A non-synonymous single nucleotide polymorphism (SNP) rs763361 (Gly307Ser) in the CD226 gene has recently been reported to be associated with several autoimmune-inflammatory diseases including type 1 diabetes and rheumatoid arthritis [
      • Hafler J.P.
      • Maier L.M.
      • Cooper J.D.
      • Plagnol V.
      • Hinks A.
      • Simmonds M.J.
      • et al.
      CD226 Gly307Ser association with multiple autoimmune diseases.
      ,
      • Wieczorek S.
      • Hoffjan S.
      • Chan A.
      • Rey L.
      • Harper L.
      • Fricke H.
      • et al.
      Novel association of the CD226 (DNAM-1) Gly307Ser polymorphism in Wegener's granulomatosis and confirmation for multiple sclerosis in German patients.
      ]. Following the notion that shared allelic variants confer susceptibility to several autoimmune disorders, the aim of the present study was to evaluate whether the Gly370Ser variant could also be implicated in the risk of plaque type psoriasis.

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