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Analysis of the expression profile of CRH–POMC system genes in vitiligo skin biopsies

      Vitiligo is a disorder characterised by depigmented patches in skin. In the involved vitiligo skin melanocytes are partially or completely lost, and no melanin is synthesized. The cause of destruction of epidermal melanocytes is complex and not fully understood – it may occur due to the factors from inside and/or outside the cell and many potential systems could be involved [
      • Ongenae K.
      • Van Geel N.
      • Naeyaert J.M.
      Evidence for an autoimmune pathogenesis of vitiligo.
      ].

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