Analysis of the expression profile of CRH–POMC system genes in vitiligo skin biopsies

      Vitiligo is a disorder characterised by depigmented patches in skin. In the involved vitiligo skin melanocytes are partially or completely lost, and no melanin is synthesized. The cause of destruction of epidermal melanocytes is complex and not fully understood – it may occur due to the factors from inside and/or outside the cell and many potential systems could be involved [
      • Ongenae K.
      • Van Geel N.
      • Naeyaert J.M.
      Evidence for an autoimmune pathogenesis of vitiligo.


      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Journal of Dermatological Science
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Ongenae K.
        • Van Geel N.
        • Naeyaert J.M.
        Evidence for an autoimmune pathogenesis of vitiligo.
        Pigment Cell Res. 2003; 16: 90-100
        • Kingo K.
        • Aunin E.
        • Karelson M.
        • Philips M.A.
        • Ratsep R.
        • Silm H.
        • et al.
        Gene expression analysis of melanocortin system in vitiligo.
        J Dermatol Sci. 2007; 48: 113-122
        • Bigliardi P.L.
        • Tobin D.J.
        • Gaveriaux-Ruff C.
        • Bigliardi-Qi M.
        Opioids and the skin—where do we stand?.
        Exp Dermatol. 2009; 18: 424-430
        • Slominski A.
        • Wortsman J.
        • Pisarchik A.
        • Zbytek B.
        • Linton E.A.
        • Mazurkiewicz J.E.
        • et al.
        Cutaneous expression of corticotropin-releasing hormone (crh), urocortin, and crh receptors.
        FASEB J. 2001; 15: 1678-1693
        • Hoogduijn M.J.
        • Ancans J.
        • Suzuki I.
        • Estdale S.
        • Thody A.J.
        Melanin-concentrating hormone and its receptor are expressed and functional in human skin.
        Biochem Biophys Res Commun. 2002; 296: 698-701
        • He L.
        • Gunn T.M.
        • Bouley D.M.
        • Lu X.Y.
        • Watson S.J.
        • Schlossman S.F.
        • et al.
        A biochemical function for attractin in agouti-induced pigmentation and obesity.
        Nat Genet. 2001; 27: 40-47
        • Smith A.G.
        • Luk N.
        • Newton R.A.
        • Roberts D.W.
        • Sturm R.A.
        • Muscat G.E.
        Melanocortin-1 receptor signaling markedly induces the expression of the NR4A nuclear receptor subgroup in melanocytic cells.
        J Biol Chem. 2008; 283: 12564-12570
        • Waits P.S.
        • Purcell W.M.
        • Fulford A.J.
        • McLeod J.D.
        Nociceptin/orphanin fq modulates human T cell function in vitro.
        J Neuroimmunol. 2004; 149: 110-120
        • Salemi S.
        • Aeschlimann A.
        • Reisch N.
        • Jungel A.
        • Gay R.E.
        • Heppner F.L.
        • et al.
        Detection of kappa and delta opioid receptors in skin—outside the nervous system.
        Biochem Biophys Res Commun. 2005; 338: 1012-1017
        • Ng E.K.
        • Leung T.N.
        • Tsui N.B.
        • Lau T.K.
        • Panesar N.S.
        • Chiu R.W.
        • et al.
        The concentration of circulating corticotropin-releasing hormone mRNA in maternal plasma is increased in preeclampsia.
        Clin Chem. 2003; 49: 727-731