Abstract
The prick test is a useful skin test for diagnosing immediate hypersensitivity response.
Sometimes it is necessary to perform prick tests on patients who have already received
antihistamines or corticosteroids. It is, however, occasionally uncertain whether
the results of prick tests are reliable. In this study, the inhibitory effects of
prednisolone (10 mg/day) and fexofenadine (120 mg/day) on the response to prick tests
induced with histamine and compound 48/80 were examined. During a 7-day-continual
drug administration, prick tests were performed 8 h after drug administration. The
inhibitory effects of fexofenadine on both the histamine- and compound 48/80-induced
skin responses were exhibited on the 1st day and persisted from 24 to 36 h after the
final administration. The histamine-induced wheal responses were not inhibited by
prednisolone, while the compound 48/80-induced flare and wheal responses were significantly
inhibited on the 5th day of drug administration. These responses returned to the baseline
level 24 h after the last drug administration. Thus, the results of skin tests performed
during administration of antihistamines and corticosteroids should be carefully interpreted.
Keywords
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Article info
Publication history
Accepted:
July 15,
2002
Received in revised form:
July 15,
2002
Received:
April 17,
2002
Identification
Copyright
© 2002 Elsevier Science Ireland Ltd. Published by Elsevier Inc. All rights reserved.
