Abstract
Various detergents are used as skin cleansing products. In some cases, skin cleanser
removes not only dirt but also valuable skin lipids. Therefore, detergents may disrupt
epidermal barrier function despite that using of detergents are required for good
skin hygiene. Lipid supplements can reverse detergent-induced dysfunction of the skin
barrier. Elevated transepidermal water loss (TEWL) and riboflavin penetration in 5%
SLS-treated rat and human skin were reversed by supplementation of monoglyceride (MG),
squalene (SQ), cholesterol ester (CE) and pseudo-ceramide (Cer2). MG and Cer2 achieved
the best results. MG appears to inhibit elution of intercellular ceramides, since
more ceramides remained when the detergent was supplemented with MG. Topical application
of Cer2 is not effective for recovery from artificially induced barrier disruption,
but supplemented Cer2 into skin cleanser has a beneficial effect for prevention of
detergent-induced barrier disruption. In conclusion, the prevention of barrier disruption
is most important matter for maintaining skin health and barrier function. Therefore,
we think that Cer2-supplemented skin cleanser is useful for conservation of skin barrier
function.
Keywords
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Article info
Publication history
Accepted:
July 10,
2002
Received in revised form:
July 8,
2002
Received:
January 24,
2002
Identification
Copyright
© 2002 Elsevier Science Ireland Ltd. Published by Elsevier Inc. All rights reserved.
