Research Article| Volume 30, ISSUE 3, P173-179, December 2002

Detergent-induced epidermal barrier dysfunction and its prevention

  • Minehiro Okuda
    Corresponding author. Present address: Safety and Environmental Research Center, Kao Corporation, 2606 Akabane, Ichikai, Haga, Tochigi 321-3497, Japan. Tel.: +81-285-68-7455; fax: +81-285-68-7452
    Department of Dermatology, Juntendo University, 2-1-1 Hongo, Bunkyo, Tokyo 113-8421, Japan

    Safety and Environmental Research Center, Kao Corporation, 2606 Akabane, Ichikai, Haga, Tochigi 321-3497, Japan
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  • Takashi Yoshiike
    Department of Dermatology, Juntendo University, 2-1-1 Hongo, Bunkyo, Tokyo 113-8421, Japan

    Department of Dermatology, Juntendo Izunagaoka Hospital, 1129 Nagaoka, Izunagaoka, Shizuoka 410-2211, Japan
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  • Hideoki Ogawa
    Department of Dermatology, Juntendo University, 2-1-1 Hongo, Bunkyo, Tokyo 113-8421, Japan
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      Various detergents are used as skin cleansing products. In some cases, skin cleanser removes not only dirt but also valuable skin lipids. Therefore, detergents may disrupt epidermal barrier function despite that using of detergents are required for good skin hygiene. Lipid supplements can reverse detergent-induced dysfunction of the skin barrier. Elevated transepidermal water loss (TEWL) and riboflavin penetration in 5% SLS-treated rat and human skin were reversed by supplementation of monoglyceride (MG), squalene (SQ), cholesterol ester (CE) and pseudo-ceramide (Cer2). MG and Cer2 achieved the best results. MG appears to inhibit elution of intercellular ceramides, since more ceramides remained when the detergent was supplemented with MG. Topical application of Cer2 is not effective for recovery from artificially induced barrier disruption, but supplemented Cer2 into skin cleanser has a beneficial effect for prevention of detergent-induced barrier disruption. In conclusion, the prevention of barrier disruption is most important matter for maintaining skin health and barrier function. Therefore, we think that Cer2-supplemented skin cleanser is useful for conservation of skin barrier function.


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        • Lee C.H.
        • Maibach H.I.
        The sodium lauryl sulfate model: an overview.
        Contact Dermat. 1995; 33: 1-7
        • Effendy I.
        • Maibach H.I.
        Surfactants and experimental irritant contact dermatitis.
        Contact Dermat. 1995; 33: 217-225
        • Ogawa H.
        • Yoshiike T.
        Atopic dermatitis: studies of skin permeability and effectiveness of topical PUVA treatment.
        Pediatr. Dermatol. 1992; 9: 383-385
        • Yoshiike T.
        • Aikawa Y.
        • Sindhavananda J.
        • et al.
        Skin barrier defect in atopic dermatitis: increased permeability of the stratum corneum using dimethyl sulfoxide and theophyline.
        J. Dermatol. Sci. 1993; 5: 92-96
        • Ogawa H.
        • Yoshiike T.
        A speculative view of atopic dermatitis: barrier dysfunction in pathogenesis.
        J. Dermatol. Sci. 1993; 5: 197-204
        • Tagami H.
        Stratum corneum as a barrier in the skin.
        Jpn. J. Dermatol. 1998; 108: 713-727
        • Loden M.
        • Olsson H.
        • Axell T.
        • et al.
        Friction, capacitance and transepidermal water loss (TEWL) in dry atopic and normal skin.
        Br. J. Dermatol. 1992; 1w6: 137-141
        • Goth C.L.
        Comparing skin irritancy in atopic and non-atopic to sodium lauryl sulfate and benzalkonium chloride using TEWL measurement.
        Environ. Dermatol. 1997; 4: 30-32
        • Denda M.
        • Koyama J.
        • Namba R.
        • et al.
        Stratum corneum lipid morphology and transepidermal water loss in normal skin and surfactant-induced scaly skin.
        Arch. Dermatol. Res. 1994; 286: 41-46
        • Paye M.
        • Morrison Jr., B.M.
        • Wilhelm K.-P.
        Skin irritancy classification of body cleansing products: comparison of two test methodologies.
        Skin Res. Technol. 1995; 1: 30-35
        • Imokawa G.
        • Akasaki G.
        • Minematsu Y.
        • et al.
        Importance of intercellular lipids in water-retention properties of the stratum corneum: induction and recovery study of surfactant dry skin.
        Arch. Dermatol. Res. 1989; 281: 45-51
        • Okuda M.
        • Yoshiike T.
        Correlation between epidermal barrier function and skin cleansing methods.
        Jpn. J. Dermatol. 2000; 110: 2115-2122
        • Imokawa G.
        • Yada Y.
        • Higuchi K.
        • et al.
        Psudo-acylceramide with linoleic acid produces selective recovery of diminished cutaneous barrier function in essential fatty acid-deficient rats and has an inhibitory effect on epidermal hyperplasia.
        J. Clin. Invest. 1994; 94: 89-96
        • Okuda M.
        • Yoshiike T.
        • Ogawa H.
        Evaluation method of stratum corneum barrier function utilizing riboflavin.
        Jpn. J. Dermatol. 1999; 109: 2103-2109
        • Kondo T.
        • Okuda M.
        • Imokawa G.
        The inhibitory effect of monoglyceride on skin roughness induced by dish-washing surfactants.
        Jpn. J. Dermatol. 1995; 105: 1217-1225
        • Ertel K.D.
        • Neumann P.B.
        • Keswick B.H.
        • Kligman A.M.
        • Stoudemayer T.
        A comparison of two antecubital fossa tests with personal care products.
        J. Toxicol. Cutan. Ocul. Toxicol. 1997; 16: 19-30
        • Ertel K.D.
        • Keswick B.H.
        • Bryant P.B.
        A forearm controlled application technique for estimating the relative mildness of personal cleansing products.
        J. Soc. Cosmet. Chem. 1995; 46: 67-76