Abstract
Staphylococcal enterotoxin B (SEB), a bacterial superantigen, is known as an immunomodulator
because it activates an extremely large number of T-cells, and induces the production
of large amounts of cytokines. In this study, we examined the effects of SEB on the
contact hypersensitivity reaction (CHR). BALB/c mice were first sensitized through
haptens applied to the back, and CHR was then induced through challenge to the left
ear using the same haptens. SEB was administered intravenously 4 weeks later, causing
a flare-up, peaking at 24 h post-administration, in the left ear that had previously
exhibited CHR. This flare-up reaction was hapten non-specific, and was inhibited by
anti-mouse tumor necrosis factor (TNF)-α antibodies. The flare-up was also suppressed
by the oral administration of cyclosporin A prior to the administration of SEB. These
results suggest that SEB induces a flare-up of CHR via the production of TNF-α.
Keywords
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Article info
Publication history
Accepted:
August 22,
2002
Received in revised form:
August 21,
2002
Received:
July 8,
2002
Identification
Copyright
© 2002 Elsevier Science Ireland Ltd. Published by Elsevier Inc. All rights reserved.
