Summary
Background:
Interferon-γ (IFN-γ) is used for the treatment of mycosis fungoides, which is a Th2
neoplasm with elevation of serum Th2 chemokines. Although therapeutic effectiveness
of IFN-γ is caused at least partly by augmented activity of cytotoxic T cells against
the tumor cells, its modulation on chemokine production remains unknown.
Objective:
Alterations in the serum levels of Th1 chemokines, IP-10 and MIG, and Th2 chemokines,
TARC and MDC, were examined in mycosis fungoides patients treated with recombinant
IFN-γ.
Methods:
Four patients with mycosis fungoides received intravenous injections of IFN-γ for
14 or 28 days. On day 0, 7, 14, and 28, sera were obtained from the patients, and the concentrations
of TARC, MDC, IP-10, and MIG were measured by ELISA, along with the percentages of
peripheral blood Th1 and Th2 cells.
Results:
Whereas the levels of TARC and MDC were decreased by IFN-γ treatment, those of IP-10
and MIG were increased. In particular, the increment of MIG was remarkable. No substantial
change of Th1 or Th2 cell number was observed.
Conclusion:
In IFN-γ treatment as well as other therapies, TARC may serve as a marker for the
disease activity of mycosis fungoides. The dramatic elevation of MIG by IFN-γ suggests
the strong dependency of MIG production on IFN-γ and the participation of MIG in skin-infiltration
of tumoricidal cytotoxic T cells.
Keywords
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Article info
Publication history
Accepted:
January 19,
2005
Received in revised form:
January 4,
2005
Received:
September 1,
2004
Identification
Copyright
© 2005 Japanese Society for Investigative Dermatology. Published by Elsevier Inc. All rights reserved.
