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LETTER TO THE EDITOR| Volume 38, ISSUE 3, P225-227, June 2005

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Exon-3 polymorphism of CTLA-4 gene in Turkish patients with vitiligo

DOI:https://doi.org/10.1016/j.jdermsci.2005.03.003
Exon-3 polymorphism of CTLA-4 gene in Turkish patients with vitiligo
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      Vitiligo is a skin disorder presenting with progressive depigmentation of the skin. It affects approximately 2% of the world population, without preference for a specific skin tone or gender [
      • Erdal M.E.
      • Tursen U.
      • Kaya T.I.
      • et al.
      Association between COMT polymorphism and vitiligo.
      Arch Dematol Res. 2002; 294: 143-146
      ]. The human cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) gene comprises three exons in addition to the leader sequence by reported Dariavach et al. [
      • Dariavach P.
      • Mattei M.G.
      • Golstein P.
      • Lefranc M.P.
      Human Ig superfamily CTLA-4 gene localization and organization.
      Cytogenet Cel Genet. 1989; 51: 983-985
      ]. They reported that human CTLA-4 maps to 2q33. Certain of these polymorphic markers have also been associated with vitiligo, suggesting that the disorder might occur in some individuals because of a genetic predisposition to the development of autoimmunity [
      • Kemp E.H.
      • Ajjan R.A.
      • Waterman E.A.
      • et al.
      Analysis of a microsatellite polymorphism of the CTLA-4 gene in patients with vitiligo.
      Br J Dermatol. 1999; 140: 73-78
      ,
      • Kristensen D.
      • Bradley C.A.
      • Hao M.
      • et al.
      Case/control association study of candidate genes for vitiligo susceptibility: tyrosine metabolism and immune response genes.
      Clin Chem. 2000; 46: 811
      ]. As yet, the molecular basis for the association of particular CTLA-4 polymorphisms with autoimmune disorders has not been established [
      • Kemp E.H.
      • Waterman E.A.
      • Weetman A.P.
      Immunological pathomechanisms in vitiligo.
      Exp Rev Mol Med. 2001; 1: 1-22
      ].

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      References

        • Erdal M.E.
        • Tursen U.
        • Kaya T.I.
        • et al.
        Association between COMT polymorphism and vitiligo.
        Arch Dematol Res. 2002; 294: 143-146
        View in Article
        • Dariavach P.
        • Mattei M.G.
        • Golstein P.
        • Lefranc M.P.
        Human Ig superfamily CTLA-4 gene localization and organization.
        Cytogenet Cel Genet. 1989; 51: 983-985
        View in Article
        • Kemp E.H.
        • Ajjan R.A.
        • Waterman E.A.
        • et al.
        Analysis of a microsatellite polymorphism of the CTLA-4 gene in patients with vitiligo.
        Br J Dermatol. 1999; 140: 73-78
        View in Article
        • Kristensen D.
        • Bradley C.A.
        • Hao M.
        • et al.
        Case/control association study of candidate genes for vitiligo susceptibility: tyrosine metabolism and immune response genes.
        Clin Chem. 2000; 46: 811
        View in Article
        • Kemp E.H.
        • Waterman E.A.
        • Weetman A.P.
        Immunological pathomechanisms in vitiligo.
        Exp Rev Mol Med. 2001; 1: 1-22
        View in Article
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        View in Article

      Article info

      Publication history

      Received: November 30, 2004

      Identification

      DOI: https://doi.org/10.1016/j.jdermsci.2005.03.003

      Copyright

      © 2005 Japanese Society for Investigative Dermatology. Published by Elsevier Inc. All rights reserved.

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