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LETTER TO THE EDITOR| Volume 38, ISSUE 3, P228-230, June 2005

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p53-Specific serum antibodies are not associated with a history of skin carcinoma in renal transplant recipients and immunocompetent individuals

DOI:https://doi.org/10.1016/j.jdermsci.2005.03.008
p53-Specific serum antibodies are not associated with a history of skin carcinoma in renal transplant recipients and immunocompetent individuals
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      Alteration of the p53 tumor suppressor gene is the most frequent genetic event found in human cancers [
      • Soussi T.
      p53 Antibodies in the sera of patients with various types of cancer: a review.
      Cancer Res. 2000; 60: 1777-1788
      ]. A recent review reported a correlation between the presence of a p53-specific antibody response and p53 mutations in the tumors [
      • Soussi T.
      p53 Antibodies in the sera of patients with various types of cancer: a review.
      Cancer Res. 2000; 60: 1777-1788
      ]. Titers of p53-specific antibodies have shown to be prognostic markers of lowered survival in patients with breast and colorectal cancers and may serve to detect lung cancer in early stages [
      • Soussi T.
      p53 Antibodies in the sera of patients with various types of cancer: a review.
      Cancer Res. 2000; 60: 1777-1788
      ].

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      Article info

      Publication history

      Received: January 13, 2005

      Identification

      DOI: https://doi.org/10.1016/j.jdermsci.2005.03.008

      Copyright

      © 2005 Japanese Society for Investigative Dermatology. Published by Elsevier Inc. All rights reserved.

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