Advertisement

Preventive effects of oral combination therapy of Vitamins B2/B6/C and l-cysteine on the development of dry skin in a guinea pig irritation model

      The hydration of the stratum corneum (SC) plays an important role in keeping the skin surface smooth and supple, whose reduction produces xerosis or dry skin. Xerosis affects even normal individuals with low sebum excretion such as children and elderlies in dry and cold winter [
      • Hara M.
      • Kikuchi K.
      • Watanabe M.
      • Denda H.
      • Koyama J.
      • Horii I.
      • et al.
      Senile xerosis: functional, morphological, and biochemical studies.
      ]. It may occur clinically as atopic xerosis [
      • Watanabe M.
      • Tagami H.
      • Horii I.
      • Takahashi M.
      • Kligman A.M.
      Functional analyses of the superficial stratum corneum in atopic dermatitis.
      ] and dry housewives’ dermatitis, in which the underlying inflammatory changes are invisible. For its prevention, we commonly use topical moisturizers [
      • Loden M.
      • Maibach H.I.
      Dry skin and moisturizers. Chemistry and function.
      ]. Their efficacy can be evaluated clinically but more precisely by utilizing the recently developed biophysical instruments that can quantitatively assess the hydration state of the skin surface in terms of high-frequency conductance or capacitance [
      • Tagami H.
      • Ohi M.
      • Iwashita K.
      • Kanamaru Y.
      • Yamada M.
      • Ichijo B.
      Evaluation of the skin surface hydration in vivo by electrical measurment.
      ,
      ]. In contrast to numerous studies on topical agents, there have been few studies reporting the effects of systemic drugs or food supplements on the SC functions [
      • Tagami H.
      • Tadaki T.
      • Koyama J.
      Functional assessment of stratum corneum under the influence of oral aromatic retinoid (etretinate) in guinea-pigs and humans. Comparison with topical retinoic acid treatment.
      ,
      • Primavera G.
      • Berardesca E.
      Clninical and instrumental evaluation of a food supplement in improving skin hydration.
      ,
      • Muggli R.
      Systemic evening primrose oil improves the biophysical skin parameters of healthy adults.
      ,
      • Namba K.
      Effect of mucopolysaccharide polysulfate (MPS-PS) on the experimental dry skin model.
      ].

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Journal of Dermatological Science
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Hara M.
        • Kikuchi K.
        • Watanabe M.
        • Denda H.
        • Koyama J.
        • Horii I.
        • et al.
        Senile xerosis: functional, morphological, and biochemical studies.
        J Geriatr Dermatol. 1993; 1: 111-120
        • Watanabe M.
        • Tagami H.
        • Horii I.
        • Takahashi M.
        • Kligman A.M.
        Functional analyses of the superficial stratum corneum in atopic dermatitis.
        Arch Dermatol Res. 1991; 127: 1689-1692
        • Loden M.
        • Maibach H.I.
        Dry skin and moisturizers. Chemistry and function.
        CRC Press, Boca Raton2000
        • Tagami H.
        • Ohi M.
        • Iwashita K.
        • Kanamaru Y.
        • Yamada M.
        • Ichijo B.
        Evaluation of the skin surface hydration in vivo by electrical measurment.
        J Invest Dermatol. 1980; 75: 500-507
      1. Serup J. Jemec G.B.E. Handbook of non-invasive methods and the skin. CRC Press, Boca Raton1995
        • Tagami H.
        • Tadaki T.
        • Koyama J.
        Functional assessment of stratum corneum under the influence of oral aromatic retinoid (etretinate) in guinea-pigs and humans. Comparison with topical retinoic acid treatment.
        Br J Dermatol. 1992; 127: 470-475
        • Primavera G.
        • Berardesca E.
        Clninical and instrumental evaluation of a food supplement in improving skin hydration.
        Int J Cosmet Sci. 2005; 27: 199-204
        • Muggli R.
        Systemic evening primrose oil improves the biophysical skin parameters of healthy adults.
        Int J Cosmet Sci. 2005; 27: 243-249
        • Namba K.
        Effect of mucopolysaccharide polysulfate (MPS-PS) on the experimental dry skin model.
        Kurume Med Assoc. 1988; 51 ([in Japanese]): 407-415
        • Tagami H.
        • Kanamaru Y.
        • Inoue K.
        • Suehisa S.
        • Inoue F.
        • Iwatsuki K.
        • et al.
        Water sorption–desorption test in vivo for functional assessment of the stratum corneum.
        J Invest Dermatol. 1982; 78: 425-428