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The hair growth promoting effect of ascorbic acid 2-phosphate, a long-acting Vitamin C derivative

      The mammalian hair follicle contains dermal papilla and dermal sheath cells derived from the mesenchyme [
      • Botchkarev V.A.
      • Kishimoto J.
      Molecular control of epithelial–mesenchymal interactions during hair follicle cycling.
      ]. It also contains epithelial cells of outer and inner root sheaths, matrix, and hair shaft, derived from the epithelium [
      • Botchkarev V.A.
      • Kishimoto J.
      Molecular control of epithelial–mesenchymal interactions during hair follicle cycling.
      ]. The post-natal hair follicle undergoes a cycle of growth (anagen), regression (catagen) and rest (telogen). The reciprocal interactions between the epithelium and mesenchyme are essential for post-natal hair growth as well as embryonic formation of hair follicle [
      • Botchkarev V.A.
      • Kishimoto J.
      Molecular control of epithelial–mesenchymal interactions during hair follicle cycling.
      ]. Dermal papilla, a cluster of specialized fibroblasts, is known to play a key role in the regulation of hair growth. Dermal papilla is encapsulated by the overlying epithelial matrix cells during hair follicle growth phase (anagen) and growth factors from dermal papilla including insulin-like growth factor 1 (IGF-1) are believed to cause epithelial cells to proliferate and differentiate to produce hair shaft [
      • Itami S.
      • Kurata S.
      • Takayasu S.
      Androgen induction of follicular epithelial cell growth is mediated via insulin-like growth factor-I from dermal papilla cells.
      ,
      • Stenn K.S.
      • Paus R.
      Controls of hair follicle cycling.
      ].

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