The mammalian hair follicle contains dermal papilla and dermal sheath cells derived
from the mesenchyme [
[1]
]. It also contains epithelial cells of outer and inner root sheaths, matrix, and hair
shaft, derived from the epithelium [
[1]
]. The post-natal hair follicle undergoes a cycle of growth (anagen), regression (catagen)
and rest (telogen). The reciprocal interactions between the epithelium and mesenchyme
are essential for post-natal hair growth as well as embryonic formation of hair follicle
[
[1]
]. Dermal papilla, a cluster of specialized fibroblasts, is known to play a key role
in the regulation of hair growth. Dermal papilla is encapsulated by the overlying
epithelial matrix cells during hair follicle growth phase (anagen) and growth factors
from dermal papilla including insulin-like growth factor 1 (IGF-1) are believed to
cause epithelial cells to proliferate and differentiate to produce hair shaft [
2
,
3
].Keywords
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Article info
Publication history
Received:
September 29,
2005
Identification
Copyright
© 2005 Japanese Society for Investigative Dermatology. Published by Elsevier Inc. All rights reserved.
