Advertisement

Reduction of lymphatic vessels in photodamaged human skin

  • Kentaro Kajiya
    Affiliations
    Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland

    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Search for articles by this author
  • Rainer Kunstfeld
    Affiliations
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Search for articles by this author
  • Jin Ho Chung
    Affiliations
    Department of Dermatology, Seoul National University College of Medicine, Seoul, South Korea
    Search for articles by this author
  • Michael Detmar
    Correspondence
    Corresponding author at: Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Wolfgang-Pauli-Str. 10, HCI H303, CH-8093 Zurich, Switzerland. Tel.: +41 44 633 7361; fax: +41 44 633 1364.
    Affiliations
    Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland

    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Search for articles by this author
      Chronic ultraviolet B (UVB) irradiation (290–320 nm) of the skin results in the degradation of extracellular matrix macromolecules, elastosis, formation of wrinkles [
      • Gilchrest BA
      Skin aging and photoaging: an overview.
      ] and enhanced risk for skin cancer [
      • Kripke ML
      Ultraviolet radiation and immunology: something new under the sun—presidential address.
      ]. We have previously found that chronic UVB irradiation of human and mouse skin induces pronounced angiogenesis of cutaneous blood vessels [
      • Yano K.
      • Oura H.
      • Detmar M
      Targeted overexpression of the angiogenesis inhibitor thrombospondin-1 in the epidermis of transgenic mice prevents ultraviolet-B-induced angiogenesis and cutaneous photo-damage.
      ,
      • Yano K.
      • Kadoya K.
      • Kajiya K.
      • Hong Y.K.
      • Detmar M.
      Ultraviolet B irradiation of human skin induces an angiogenic switch that is mediated by upregulation of vascular endothelial growth factor and by downregulation of thrombospondin-1.
      ]. Moreover, targeted overexpression of vascular endothelial growth factor (VEGF)-A enhanced the sensitivity to UVB-induced cutaneous photodamage [
      • Hirakawa S.
      • Fujii S.
      • Kajiya K.
      • Yano K.
      • Detmar M.
      Vascular endothelial growth factor promotes sensitivity to ultraviolet B-induced cutaneous photodamage.
      ], whereas transgenic overexpression of the angiogenesis inhibitor thrombospondin-1 in the epidermis completely prevented UVB-induced skin damage [
      • Yano K.
      • Oura H.
      • Detmar M
      Targeted overexpression of the angiogenesis inhibitor thrombospondin-1 in the epidermis of transgenic mice prevents ultraviolet-B-induced angiogenesis and cutaneous photo-damage.
      ]. Together, these findings indicate that the cutaneous blood vasculature plays a critical role in the mediation of photodamage. In contrast, the role of cutaneous lymphatic vessels in the response to UVB irradiation has remained unknown.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Journal of Dermatological Science
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Gilchrest BA
        Skin aging and photoaging: an overview.
        J Am Acad Dermatol. 1989; 21: 610-613
        • Kripke ML
        Ultraviolet radiation and immunology: something new under the sun—presidential address.
        Cancer Res. 1994; 54: 6102-6105
        • Yano K.
        • Oura H.
        • Detmar M
        Targeted overexpression of the angiogenesis inhibitor thrombospondin-1 in the epidermis of transgenic mice prevents ultraviolet-B-induced angiogenesis and cutaneous photo-damage.
        J Invest Dermatol. 2002; 118: 800-805
        • Yano K.
        • Kadoya K.
        • Kajiya K.
        • Hong Y.K.
        • Detmar M.
        Ultraviolet B irradiation of human skin induces an angiogenic switch that is mediated by upregulation of vascular endothelial growth factor and by downregulation of thrombospondin-1.
        Br J Dermatol. 2005; 152: 115-121
        • Hirakawa S.
        • Fujii S.
        • Kajiya K.
        • Yano K.
        • Detmar M.
        Vascular endothelial growth factor promotes sensitivity to ultraviolet B-induced cutaneous photodamage.
        Blood. 2005; 105: 2392-2399
        • Cueni L.N.
        • Detmar M.
        New insights into the molecular control of the lymphatic vascular system and its role in disease.
        J Invest Dermatol. 2006; 126: 2167-2177
        • Kajiya K.
        • Detmar M.
        An important role of lymphatic vessels in the control of UVB-induced edema formation and inflammation.
        J Invest Dermatol. 2006; 126: 919-921
        • Kajiya K.
        • Hirakawa S.
        • Detmar M.
        Vascular endothelial growth factor-A mediates ultraviolet B-induced impairment of lymphatic vessel function.
        Am J Pathol. 2006; 169: 1496-1503
        • Chung J.H.
        • Lee S.H.
        • Youn C.S.
        • Park B.J.
        • Kim K.H.
        • Park K.C.
        • et al.
        Cutaneous photodamage in Koreans: influence of sex, sun exposure, smoking, and skin color.
        Arch Dermatol. 2001; 137: 1043-1051
        • Kunstfeld R.
        • Hirakawa S.
        • Hong Y.K.
        • Schacht V.
        • Lange-Asschenfeldt B.
        • Velasco P.
        • et al.
        Induction of cutaneous delayed-type hypersensitivity reactions in VEGF-A transgenic mice results in chronic skin inflammation associated with persistent lymphatic hyperplasia.
        Blood. 2004; 104: 1048-1057