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Inhibitory effects of Paroxetine on the development of atopic dermatitis-like lesions in NC/Nga mice

  • Ju Jiang
    Affiliations
    Atopy (Allergy) Research Center, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan

    Department of Dermatology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan
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  • Takatoshi Kuhara
    Correspondence
    Corresponding author. Tel.: +81 3 5802 1592; fax: +81 3 3813 5548.
    Affiliations
    Atopy (Allergy) Research Center, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan
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  • Rie Ueki
    Affiliations
    Dermatology Unit, Juntendo Tokyo Koto Geriatric Medical Center, 3-3-20 Shinsuna, Koto-ku, Tokyo 136-0075, Japan
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  • Yan Zheng
    Affiliations
    Department of Dermatology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan
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  • Hajime Suto
    Affiliations
    Atopy (Allergy) Research Center, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan

    Department of Dermatology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan
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  • Shigaku Ikeda
    Affiliations
    Department of Dermatology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan
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  • Hideoki Ogawa
    Affiliations
    Atopy (Allergy) Research Center, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan

    Department of Dermatology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan
    Search for articles by this author
      Atopic dermatitis (AD) is a chronic inflammatory skin disease in which pruritus is the most serious problem, because scratching worsens the dermatitis itself in AD patients [
      • Koblenzer C.S.
      Itching and the atopic skin.
      ]. The prevention of the pruritic sensation and/or pruritus-associated scratching behavior have/has been considered as an effective treatment for AD [
      • Mihara K.
      • Kuratani K.
      • Matsui T.
      • Nakamura M.
      • Yokota K.
      Vital role of the itch–scratch response in development of spontaneous dermatitis in NC/Nga mice.
      ]. Antihistamine treatment is not sufficient to inhibit pruritus in AD patients; topical steroid application is crucial for the management of AD, but steroid cannot be used for long periods due to frequently observed side-effects. Paroxetine, a selective serotonin reuptake inhibitor (SSRI), has been used as an antidepressant agent in the clinical treatment in human and it was also reported that Paroxetine was effective in the treatment of intractable pruritus, especially caused by malignant diseases [
      • Zylicz Z.
      • Smits C.
      • Krajnik M.
      Paroxetine for pruritus in advanced cancer.
      ,
      • Zylicz Z.
      • Krajnik M.
      • Sorge A.A.
      • Costantini M.
      Paroxetine in the treatment of severe non-dermatological pruritus: a randomized controlled trial.
      ]. However, it has never been reported whether or not Paroxetine is effective in the treatment of pruritus in AD patients. In the present study, we used NC/Nga mice, an animal model for human AD [
      • Suto H.
      • Matsuda H.
      • Mitsuishi K.
      • Hira K.
      • Uchida T.
      • Unno T.
      • Ogawa H.
      • Ra C.
      NC/Nga mice: a mouse model for atopic dermatitis.
      ], to assess the inhibitory effect of Paroxetine on the development of dermatitis and to obtain basic information about the usefulness of Paroxetine in the treatment of AD.

      Keywords

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      References

        • Koblenzer C.S.
        Itching and the atopic skin.
        J Allergy Clin Immun. 1999; 104: S109-S113
        • Mihara K.
        • Kuratani K.
        • Matsui T.
        • Nakamura M.
        • Yokota K.
        Vital role of the itch–scratch response in development of spontaneous dermatitis in NC/Nga mice.
        Brit J Dermatol. 2004; 151: 335-345
        • Zylicz Z.
        • Smits C.
        • Krajnik M.
        Paroxetine for pruritus in advanced cancer.
        J Pain Symptom Manag. 1998; 16: 121-124
        • Zylicz Z.
        • Krajnik M.
        • Sorge A.A.
        • Costantini M.
        Paroxetine in the treatment of severe non-dermatological pruritus: a randomized controlled trial.
        J Pain Symptom Manag. 2003; 26: 1105-1112
        • Suto H.
        • Matsuda H.
        • Mitsuishi K.
        • Hira K.
        • Uchida T.
        • Unno T.
        • Ogawa H.
        • Ra C.
        NC/Nga mice: a mouse model for atopic dermatitis.
        Int Arch Allergy Imm. 1999; 120: 70-75
        • Kesim M.
        • Duman E.N.
        • Kadioglu M.
        • Yaris E.
        • Kalyoncu N.I.
        • Erciyes N.
        The different roles of 5-HT2 and 5-HT3 receptors on antinociceptive effect of paroxetine in chemical stimuli in mice.
        J Pharmacol Sci. 2005; 97: 61-66
        • Dunbar G.C.
        Paroxetine in the elderly: a comparative meta-analysis against standard antidepressant pharmacotherapy.
        Pharmacology. 1995; 51: 137-144
        • Pae C.U.
        • Patkar A.A.
        Paroxetine: current status in psychiatry.
        Expert Rev Neurother. 2007; 7: 107-120
        • Seiffert K.
        • Hilbert E.
        • Schaechinger H.
        • Zouboulis C.C.
        • Deter H.C.
        Psychophysiological reactivity under mental stress in atopic dermatitis.
        Dermatology. 2005; 210: 286-293
        • Hashiro M.
        • Okumura M.
        Anxiety, depression and psychosomatic symptoms in patients with atopic dermatitis: comparison with normal controls and among groups of different degrees of severity.
        J Dermatol Sci. 1997; 14: 63-67