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Indications that topical l-carnitin-l-tartrate promotes human hair growth in vivo

      l-Carnitine is essential for the intramitochondrial transport of long-chain fatty acids for β-oxidation [
      • Alesci S.
      • De Martino M.U.
      • Kino T.
      • Ilias I.
      l-Carnitine is a modulator of the glucocorticoid receptor alpha.
      ,
      • Rebouche C.J.
      Kinetics: pharmacokinetics, and regulation of l-carnitine and acetyl-l-carnitine metabolism.
      ,
      • Jogl G.
      • Hsiao Y.S.
      • Tong L.
      Structure and function of carnitine acyltransferases.
      ]. Recently, we have shown that l-carnitine-l-tartrate (CT) is able to increase hair shaft elongation and prolong anagen by upregulation of proliferation and downregulation of apoptosis in organ-cultured human scalp hair follicles [

      Foitzik K, Hoting E, Pertile P, Förster K, Paus R. L-Carnitine-tartrate promotes human hair growth in vitro. J Invest Dermatol 2006;126:s27 (P146).

      ]. In order to test whether CT is also able to stimulate hair growth in human scalp hair follicles (HF) in vivo, we have performed a small, double-blind, randomised, placebo-controlled observational study of topical CT administration over 6 months twice a day. Penetration of CT into the skin, employing a liposomal hair tonic (Henkel, Düsseldorf, Germany) versus a conventional hair tonic was investigated, using the BUS (bovine udder model).

      Abbreviations:

      HFs (hair follicles), CT (carnitine tartrate), BUS (bovine udder skin)

      Keywords

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      References

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        • De Martino M.U.
        • Kino T.
        • Ilias I.
        l-Carnitine is a modulator of the glucocorticoid receptor alpha.
        Ann N Y Acad Sci. 2004; 1024: 147-152
        • Rebouche C.J.
        Kinetics: pharmacokinetics, and regulation of l-carnitine and acetyl-l-carnitine metabolism.
        Ann N Y Acad Sci. 2004; 1033: 30-41
        • Jogl G.
        • Hsiao Y.S.
        • Tong L.
        Structure and function of carnitine acyltransferases.
        Ann N Y Acad Sci. 2004; 1033: 17-29
      1. Foitzik K, Hoting E, Pertile P, Förster K, Paus R. L-Carnitine-tartrate promotes human hair growth in vitro. J Invest Dermatol 2006;126:s27 (P146).

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