Oral mucositis is a common complication of radiotherapy and/or chemotherapy in patients
with squamous cell carcinoma of the head and neck. Ionizing radiation causes loss
of stem cells having renewal capacity in the basal layer of the mucosa, which is the
beginning of radiation mucositis [
[1]
]. Embryonic or mesenchymal stem cells have been reported to resist oxidative stress
from noxious stimuli such as radiation [
2
,
3
]. However, the radiation resistance of oral mucosal stem cells is still unknown. In
this study, we attempted to separate stem cell-rich subpopulation from human oral
mucosa by differential adhesion to collagen type IV, the method being used to isolate
epidermal stem cells [
[4]
]. Radiation sensitivity of the stem cell-rich and stem cell-poor subpopulations was
compared.To read this article in full you will need to make a payment
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References
- The pathobiology of mucositis.Nat Rev Cancer. 2004; 4: 277-284
- Stress defense in murine embryonic stem cells is superior to that of various differentiated murine cells.Stem Cells. 2004; 22: 962-971
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Article info
Publication history
Published online: July 12, 2010
Received:
July 18,
2007
Identification
Copyright
© 2007 Japanese Society for Investigative Dermatology. Published by Elsevier Inc. All rights reserved.
