The best method to reduce skin cancer risk is preventing intensive sunlight exposure
through lifestyle modification (protective clothing, avoidance) and sunscreen application.
However, many individuals do not follow these measures and become sunburned. Unfortunately,
sunscreens are not effective once damage has occurred [
[1]
]. Compounds that reverse skin trauma after UV exposure are therefore necessary to
supplement sunscreen use, as a second line of defense. A post-exposure product should
reduce DNA damage [
[2]
], inflammation and immune suppression [
[3]
], as well as prevent alterations in intercellular adhesion proteins, such as E-cadherin,
which disrupt skin homeostasis and are associated with skin cancer development and
progression [
4
,
5
].Keywords
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References
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Article info
Publication history
Published online: July 12, 2010
Received:
July 2,
2007
Identification
Copyright
© 2008 Japanese Society for Investigative Dermatology. Published by Elsevier Inc. All rights reserved.
