Summary
Background
Mycosis fungoides (MF) is a T cell neoplasm with elevation of serum Th2 chemokines.
Although interferon-γ (IFN-γ) administration and narrowband-UVB (NB-UVB) phototherapy
are used for the treatment of MF, a combination therapy of these two modalities is
not fully established.
Objectives
To define whether the combination of IFN-γ and NB-UVB affects the balance of serum
levels of Th1 and Th2 chemokines in patients with MF.
Methods
Twelve patients with MF received intravenous or intramuscular injections of recombinant
IFN-γ (rIFN-γ) or natural IFN-γ (nIFN-γ) in combination with NB-UVB phototherapy.
As control, three MF patients were treated with NB-UVB monotherapy. At the beginning
and cessation of therapy, the concentrations of serum Th2 chemokines, TARC/CCL17 and
MDC/CCL22, and Th1 chemokines, IP-10/CXCL10 and MIG/CXCL9 were measured by ELISA.
Results
Before treatment, not only Th2 chemokines but also Th1 chemokines were elevated in
the patients. Whereas no significant changes were observed in the levels of TARC and
MDC, IP-10 and MIG were further elevated by the combination of IFN-γ and NB-UVB. On
the other hand, NB-UVB monotherapy did not change the level of either Th1 or Th2 chemokine.
Conclusions
The combination of IFN-γ and NB-UVB elevated serum Th1 chemokines but unaffected Th2
chemokines. Since NB-UVB monotherapy could not affect the chemokine levels, the effect
of the combination therapy is attributable to IFN-γ. Given the role of Th1 chemokines
for tumor-attacking T cell recruitment at the early stage of MF, the therapy may exert
a beneficial effect for early MF.
Keywords
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Article info
Publication history
Published online: July 12, 2010
Accepted:
December 3,
2007
Received in revised form:
November 21,
2007
Received:
July 28,
2007
Identification
Copyright
© 2007 Japanese Society for Investigative Dermatology. Published by Elsevier Inc. All rights reserved.
