Summary
The immunomodulator, AS101, inhibits production of IL-10, IL-4 and expression of p38
MAPK, while increasing production of IFNγ and IL-2. Together with its excellent clinical
safety profile in humans, suggests a potential therapeutic use for AD.
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References
- Production of lymphocyte-derived cytokines by whole umbilical cord blood cultures stimulated with mitogens and allergens.Cytokines. 2003; 21: 74-83
- Severe atopic dermatitis is associated with a reduced frequency of IL-10 producing allergen-specific CD4+ T cells.Clin Exp Dermatol. 2006; 31: 689-694
- Induction of T “regulatory” cells by standardized house dust mite immunotherapy: an increase in CD4+ CD25+ interleukin-10+ T cells expressing peripheral tissue trafficking markers.Clin Exp Allergy. 2004; 34: 1209-1219
- Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells.J Exp Med. 2004; 199: 1567-1575
- Improvement of dermatitis by iontophoretically delivered antisense oligonucleotides for interleukin-10 in NC̃Nga mice.Gene Therapy. 2004; 11: 317-324
- Inhibition of interleukin-10 by the immunomodulator AS101 reduces mesangial cell proliferation in experimental mesangioproliferative glomerulonephritis: association with dephosphorylation of STAT3.J Biol Chem. 2004; 4: 24724-24732
- Predominance of TH1 response in tumor-bearing mice and cancer patients treated with AS101.J Natl Cancer Inst. 1996; 88: 1276-1284
- Diagnostic features of atopic dermatitis.Acta Dermatol Venereol. 1980; 92: 44-47
- Thyphronitis G. IL-2 and IL-10 production by human CD4+ T cells is differentially regulated by p38: mode of stimulation-dependent regulation of IL-2.Neuroimmunomodulation. 2004; 11: 199-208
- Down regulation effects of IL-4 and IL-10 on the IFNγ response in Atopic dermatitis.J Immunol. 1995; 154: 6174-6181
Article info
Publication history
Published online: July 12, 2010
Received:
August 23,
2007
Identification
Copyright
© 2008 Japanese Society for Investigative Dermatology. Published by Elsevier Inc. All rights reserved.