Letter to the Editor| Volume 50, ISSUE 3, P240-242, June 2008

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Clinical association of serum interleukin-17 levels in systemic sclerosis: Is systemic sclerosis a Th17 disease?

      Systemic sclerosis (SSc) is a connective tissue disorder characterized by fibrosis and vascular changes in the skin and internal visceral organs, with an autoimmune background. The increase of the collagen deposition is characteristic with SSc and depends on various cytokines. Among them, transforming growth factor-β (TGF-β) is considered to play a central role in the pathogenesis of SSc [
      • Ihn H.
      Autocrine TGF-beta signaling in the pathogenesis of systemic sclerosis.


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