Systemic sclerosis (SSc) is a connective tissue disorder characterized by fibrosis
and vascular changes in the skin and internal visceral organs, with an autoimmune
background. The increase of the collagen deposition is characteristic with SSc and
depends on various cytokines. Among them, transforming growth factor-β (TGF-β) is
considered to play a central role in the pathogenesis of SSc [
[1]
].Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of Dermatological ScienceAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Autocrine TGF-beta signaling in the pathogenesis of systemic sclerosis.J Dermatol Sci. 2008; 49: 103-113
- TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells.Immunity. 2006; 24: 179-189
- Elevated serum interleukin-6 levels associated with active disease in systemic connective tissue disorders.Clin Exp Rheumatol. 1995; 13: 17-22
- Increased interleukin-17 production in patients with systemic sclerosis.Arthritis Rheum. 2000; 43: 2455-2463
- Elevated circulating CD40L concentrations in patients with systemic sclerosis.J Rheumatol. 2004; 31: 514-519
- A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17.Nat Immunol. 2005; 6: 1133-1141
- Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses.Annu Rev Immunol. 2004; 22: 531-562
- Development, cytokine profile and function of human interleukin 17-producing helper T cells.Nat Immunol. 2007; 8: 950-957
- Human IL-17: a novel cytokine derived from T cells.J Immunol. 1995; 155: 5483-5486
- TGFbeta1, a “Jack of all trades”: the link with pro-inflammatory IL-17-producing T cells.Trends Immunol. 2006; 27: 358-361
Article info
Publication history
Published online: July 12, 2010
Received:
August 20,
2007
Identification
Copyright
© 2008 Japanese Society for Investigative Dermatology. Published by Elsevier Inc. All rights reserved.
