Systemic sclerosis (SSc) is a connective tissue disorder characterized by fibrosis and vascular changes in the skin and internal visceral organs, with an autoimmune background. The increase of the collagen deposition is characteristic with SSc and depends on various cytokines. Among them, transforming growth factor-β (TGF-β) is considered to play a central role in the pathogenesis of SSc [
- Ihn H.
Autocrine TGF-beta signaling in the pathogenesis of systemic sclerosis.
J Dermatol Sci. 2008; 49: 103-113
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- Autocrine TGF-beta signaling in the pathogenesis of systemic sclerosis.J Dermatol Sci. 2008; 49: 103-113
- TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells.Immunity. 2006; 24: 179-189
- Elevated serum interleukin-6 levels associated with active disease in systemic connective tissue disorders.Clin Exp Rheumatol. 1995; 13: 17-22
- Increased interleukin-17 production in patients with systemic sclerosis.Arthritis Rheum. 2000; 43: 2455-2463
- Elevated circulating CD40L concentrations in patients with systemic sclerosis.J Rheumatol. 2004; 31: 514-519
- A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17.Nat Immunol. 2005; 6: 1133-1141
- Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses.Annu Rev Immunol. 2004; 22: 531-562
- Development, cytokine profile and function of human interleukin 17-producing helper T cells.Nat Immunol. 2007; 8: 950-957
- Human IL-17: a novel cytokine derived from T cells.J Immunol. 1995; 155: 5483-5486
- TGFbeta1, a “Jack of all trades”: the link with pro-inflammatory IL-17-producing T cells.Trends Immunol. 2006; 27: 358-361
Published online: July 12, 2010
Received: August 20, 2007
© 2008 Japanese Society for Investigative Dermatology. Published by Elsevier Inc. All rights reserved.