The number of patients suffering from diabetic foot ulcers [
[1]
] and rheumatic ulcers [
[2]
] is increasing rapidly. Vitiligo is an acquired depigmented skin disorder that results
from the destruction of melanocytes with unknown etiology. Suction blisters were first
used for the transplantation of viable epidermis in vitiligo lesions and chronic wounds
[
[3]
], followed by a simplified modification to form blisters [
[4]
]. We have previously reported the usefulness of epidermal sheet grafts to treat intractable
skin ulcers caused by autoimmune diseases [
[2]
], diabetes mellitus [
[1]
] or other diseases [
5
,
6
] through their unique actions that differ from conventional skin grafts that include
dermal components [
7
,
8
].Abbreviation:
T-SB (time required to generate suction blister)Keywords
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References
- Rapid healing of intractable diabetic foot ulcers with exposed bones following a novel therapy of exposing bone marrow cells and then grafting epidermal sheets.Br J Dermatol. 2004; 151: 1019-1028
- Prevention of amputation caused by rheumatic diseases following a novel therapy of exposing bone marrow, occlusive dressing and subsequent epidermal grafting.Br J Dermatol. 2005; 152: 664-672
- Epidermal grafting. An original technique and its application in achromic and granulating areas.Arch Dermatol. 1971; 104: 592-600
- Surgical pearl: suction syringe for epidermal grafting.J Am Acad Dermatol. 1997; 37: 638-639
- Epithelial–mesenchymal interactions in wounds: treatment of palmoplantar wounds by nonpalmoplantar pure epidermal sheet grafts.Arch Dermatol. 2001; 137: 621-628
- Cutaneous wound healing: an update.J Dermatol. 2001; 28: 521-534
- Mesenchymal–epithelial interactions in the skin: increased expression of dickkopf1 by palmoplantar fibroblasts inhibits melanocyte growth and differentiation.J Cell Biol. 2004; 165: 275-285
- Dickkopf 1 (DKK1) regulates skin pigmentation and thickness by affecting Wnt/β-catenin signaling in keratinocytes.Faseb J. 2007;
- Suction blister induction time: 15 min or 150 min?.Dermatol Surg. 2000; 26: 754-756
- Successful treatment of vitiligo with PUVA-pigmented autologous epidermal grafting.Int J Dermatol. 1996; 35: 518-522
Article info
Publication history
Published online: July 12, 2010
Received:
January 8,
2008
Identification
Copyright
© 2008 Japanese Society for Investigative Dermatology. Published by Elsevier Inc. All rights reserved.
